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setd1a antibody  (Bio-Techne corporation)


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    Bio-Techne corporation setd1a antibody
    Setd1a Antibody, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 91/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/setd1a antibody/product/Bio-Techne corporation
    Average 91 stars, based on 8 article reviews
    setd1a antibody - by Bioz Stars, 2026-05
    91/100 stars

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    Figure 7. Schematic model of PHGDH monoubiquitination–promoted CRC metastasis. Cul4A-DDB1–mediated K146 monoubiquitination of PHGDH recruits DNAJA1 to facilitate tetrameric formation of PHGDH, which enhances its enzy- matic activity and increases SAM levels. Increased levels of SAM specifically initiate <t>SETD1A-mediated</t> histone H3K4me3 to upregulate LAMC2 and CYR61 expression, thereby promoting tumor cell migration and CRC metastasis. 3-PG, 3-phosphoglycerate; 3-PO, 3-phosphooxypyruvate.
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    Figure 7. Schematic model of PHGDH monoubiquitination–promoted CRC metastasis. Cul4A-DDB1–mediated K146 monoubiquitination of PHGDH recruits DNAJA1 to facilitate tetrameric formation of PHGDH, which enhances its enzy- matic activity and increases SAM levels. Increased levels of SAM specifically initiate SETD1A-mediated histone H3K4me3 to upregulate LAMC2 and CYR61 expression, thereby promoting tumor cell migration and CRC metastasis. 3-PG, 3-phosphoglycerate; 3-PO, 3-phosphooxypyruvate.

    Journal: Journal of Clinical Investigation

    Article Title: Cul4A-DDB1–mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine

    doi: 10.1172/jci146187

    Figure Lengend Snippet: Figure 7. Schematic model of PHGDH monoubiquitination–promoted CRC metastasis. Cul4A-DDB1–mediated K146 monoubiquitination of PHGDH recruits DNAJA1 to facilitate tetrameric formation of PHGDH, which enhances its enzy- matic activity and increases SAM levels. Increased levels of SAM specifically initiate SETD1A-mediated histone H3K4me3 to upregulate LAMC2 and CYR61 expression, thereby promoting tumor cell migration and CRC metastasis. 3-PG, 3-phosphoglycerate; 3-PO, 3-phosphooxypyruvate.

    Article Snippet: Rabbit polyclonal antibodies recognizing KMT2A (catalog NB600-256), SETD1A (catalog NB100-558), SETD1B (catalog NBP1-28684), UbcH6 (catalog NBP1-78983B), and DCAF16 (catalog NBP2-82812) were purchased from Novus Biologicals, Bio-Techne.

    Techniques: Activity Assay, Expressing, Migration