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Schematic summarizing the effects of FATP1 overexpression in the mouse RPE. Rhodopsin, the light-sensitive protein in rods, is located in the disk membranes of rod outer segments (ROS). Absorption of a photon (hʋ) induces 11- cis to all- trans isomerization of retinaldehyde. All- trans -retinal then dissociates from rhodopsin and is reduced to all- trans -retinol, which is taken up by an RPE cell. Also in the RPE, FATP1 promotes long chain fatty acid (LCFA) uptake, thus providing LCFA-CoA for formation of phospholipids. All- trans -retinol is esterified with a phosphatidylcholine (PC)-derived LCFA to form all- trans -retinyl esters in a reaction catalyzed by LRAT. <t>RPE65</t> then converts all- trans -retinyl esters to 11- cis -retinol. All-trans retinyl esters accumulate in the transgenic hFATP1TG RPE, suggesting increased levels of LCFAs and/or inhibition of RPE65. In ROS, the response to light remains unchanged, although rhodopsin expression increases. This increase is related to a greater number of PRs and their longer outer segments. Consequently, the rate of all- trans retinal formation is elevated, resulting in susceptibility to degeneration induced by light.
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Schematic summarizing the effects of FATP1 overexpression in the mouse RPE. Rhodopsin, the light-sensitive protein in rods, is located in the disk membranes of rod outer segments (ROS). Absorption of a photon (hʋ) induces 11- cis to all- trans isomerization of retinaldehyde. All- trans -retinal then dissociates from rhodopsin and is reduced to all- trans -retinol, which is taken up by an RPE cell. Also in the RPE, FATP1 promotes long chain fatty acid (LCFA) uptake, thus providing LCFA-CoA for formation of phospholipids. All- trans -retinol is esterified with a phosphatidylcholine (PC)-derived LCFA to form all- trans -retinyl esters in a reaction catalyzed by LRAT. <t>RPE65</t> then converts all- trans -retinyl esters to 11- cis -retinol. All-trans retinyl esters accumulate in the transgenic hFATP1TG RPE, suggesting increased levels of LCFAs and/or inhibition of RPE65. In ROS, the response to light remains unchanged, although rhodopsin expression increases. This increase is related to a greater number of PRs and their longer outer segments. Consequently, the rate of all- trans retinal formation is elevated, resulting in susceptibility to degeneration induced by light.
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https://www.bioz.com/result/anti rpe65/product/Novus Biologicals
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Schematic summarizing the effects of FATP1 overexpression in the mouse RPE. Rhodopsin, the light-sensitive protein in rods, is located in the disk membranes of rod outer segments (ROS). Absorption of a photon (hʋ) induces 11- cis to all- trans isomerization of retinaldehyde. All- trans -retinal then dissociates from rhodopsin and is reduced to all- trans -retinol, which is taken up by an RPE cell. Also in the RPE, FATP1 promotes long chain fatty acid (LCFA) uptake, thus providing LCFA-CoA for formation of phospholipids. All- trans -retinol is esterified with a phosphatidylcholine (PC)-derived LCFA to form all- trans -retinyl esters in a reaction catalyzed by LRAT. <t>RPE65</t> then converts all- trans -retinyl esters to 11- cis -retinol. All-trans retinyl esters accumulate in the transgenic hFATP1TG RPE, suggesting increased levels of LCFAs and/or inhibition of RPE65. In ROS, the response to light remains unchanged, although rhodopsin expression increases. This increase is related to a greater number of PRs and their longer outer segments. Consequently, the rate of all- trans retinal formation is elevated, resulting in susceptibility to degeneration induced by light.
Mouse Monoclonal Antibody To Rpe65, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Schematic summarizing the effects of FATP1 overexpression in the mouse RPE. Rhodopsin, the light-sensitive protein in rods, is located in the disk membranes of rod outer segments (ROS). Absorption of a photon (hʋ) induces 11- cis to all- trans isomerization of retinaldehyde. All- trans -retinal then dissociates from rhodopsin and is reduced to all- trans -retinol, which is taken up by an RPE cell. Also in the RPE, FATP1 promotes long chain fatty acid (LCFA) uptake, thus providing LCFA-CoA for formation of phospholipids. All- trans -retinol is esterified with a phosphatidylcholine (PC)-derived LCFA to form all- trans -retinyl esters in a reaction catalyzed by LRAT. RPE65 then converts all- trans -retinyl esters to 11- cis -retinol. All-trans retinyl esters accumulate in the transgenic hFATP1TG RPE, suggesting increased levels of LCFAs and/or inhibition of RPE65. In ROS, the response to light remains unchanged, although rhodopsin expression increases. This increase is related to a greater number of PRs and their longer outer segments. Consequently, the rate of all- trans retinal formation is elevated, resulting in susceptibility to degeneration induced by light.

Journal: PLoS ONE

Article Title: Fatty acid transport protein 1 regulates retinoid metabolism and photoreceptor development in mouse retina

doi: 10.1371/journal.pone.0180148

Figure Lengend Snippet: Schematic summarizing the effects of FATP1 overexpression in the mouse RPE. Rhodopsin, the light-sensitive protein in rods, is located in the disk membranes of rod outer segments (ROS). Absorption of a photon (hʋ) induces 11- cis to all- trans isomerization of retinaldehyde. All- trans -retinal then dissociates from rhodopsin and is reduced to all- trans -retinol, which is taken up by an RPE cell. Also in the RPE, FATP1 promotes long chain fatty acid (LCFA) uptake, thus providing LCFA-CoA for formation of phospholipids. All- trans -retinol is esterified with a phosphatidylcholine (PC)-derived LCFA to form all- trans -retinyl esters in a reaction catalyzed by LRAT. RPE65 then converts all- trans -retinyl esters to 11- cis -retinol. All-trans retinyl esters accumulate in the transgenic hFATP1TG RPE, suggesting increased levels of LCFAs and/or inhibition of RPE65. In ROS, the response to light remains unchanged, although rhodopsin expression increases. This increase is related to a greater number of PRs and their longer outer segments. Consequently, the rate of all- trans retinal formation is elevated, resulting in susceptibility to degeneration induced by light.

Article Snippet: Other primary antibodies were mouse anti-rhodopsin (Novus Biologicals NBP1-47602, 1:500), mouse anti-α-tubulin (Sigma T5168, 1:1000), RPE65 (Novus Biologicals, 1:200), LRAT (Abcam ab73401, 1:200), RDH5 (Abnova HA00005959-A01, 1:500), and DGAT1 (Novus Biologicals NB110-41487, 1/500).

Techniques: Over Expression, Derivative Assay, Transgenic Assay, Inhibition, Expressing