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Representative immunohistochemical images of <t>FGFR1–4</t> protein expression in lung tissue (A,C,E,G) adjacent to NSCLC (B,D,F,H), shown at 200× magnification. FGFR1–4, fibroblast growth factor receptor 1–4; NSCLC, non-small cell lung cancer.
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Representative immunohistochemical images of <t>FGFR1–4</t> protein expression in lung tissue (A,C,E,G) adjacent to NSCLC (B,D,F,H), shown at 200× magnification. FGFR1–4, fibroblast growth factor receptor 1–4; NSCLC, non-small cell lung cancer.
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Representative immunohistochemical images of <t>FGFR1–4</t> protein expression in lung tissue (A,C,E,G) adjacent to NSCLC (B,D,F,H), shown at 200× magnification. FGFR1–4, fibroblast growth factor receptor 1–4; NSCLC, non-small cell lung cancer.
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Representative immunohistochemical images of FGFR1–4 protein expression in lung tissue (A,C,E,G) adjacent to NSCLC (B,D,F,H), shown at 200× magnification. FGFR1–4, fibroblast growth factor receptor 1–4; NSCLC, non-small cell lung cancer.

Journal: Translational Lung Cancer Research

Article Title: TTF-1 and p40 co-expression defines a distinct subtype of non-small cell lung cancer with frequent TP53 mutations and FGFR pathway dysregulation

doi: 10.21037/tlcr-2025-690

Figure Lengend Snippet: Representative immunohistochemical images of FGFR1–4 protein expression in lung tissue (A,C,E,G) adjacent to NSCLC (B,D,F,H), shown at 200× magnification. FGFR1–4, fibroblast growth factor receptor 1–4; NSCLC, non-small cell lung cancer.

Article Snippet: Primary antibodies used for FGFR detection were: FGFR1 (NB100-2080, Novus Biologicals, USA; pH 6.0, 1:100), FGFR2 (H00002263-M01, Abnova, Taiwan; pH 6.0, 1:600), FGFR3 (B-9: sc-13121, Santa Cruz Biotechnology; pH 6.0, 1:50), and FGFR4 (M00769-2, Boster Bio, USA; pH 6.0, 1:500).

Techniques: Immunohistochemical staining, Expressing

Kaplan-Meier curve showing OS probability among p40/TTF-1 double expressor NSCLC cases, comparing patients with FGFR1 overexpression and/or amplification (FGFR1alt) to those without these alterations (FGFR1wt). The P value was calculated using the log-rank test. FGFR, fibroblast growth factor receptor; NSCLC, non-small cell lung cancer; OS, overall survival; wt, wild-type.

Journal: Translational Lung Cancer Research

Article Title: TTF-1 and p40 co-expression defines a distinct subtype of non-small cell lung cancer with frequent TP53 mutations and FGFR pathway dysregulation

doi: 10.21037/tlcr-2025-690

Figure Lengend Snippet: Kaplan-Meier curve showing OS probability among p40/TTF-1 double expressor NSCLC cases, comparing patients with FGFR1 overexpression and/or amplification (FGFR1alt) to those without these alterations (FGFR1wt). The P value was calculated using the log-rank test. FGFR, fibroblast growth factor receptor; NSCLC, non-small cell lung cancer; OS, overall survival; wt, wild-type.

Article Snippet: Primary antibodies used for FGFR detection were: FGFR1 (NB100-2080, Novus Biologicals, USA; pH 6.0, 1:100), FGFR2 (H00002263-M01, Abnova, Taiwan; pH 6.0, 1:600), FGFR3 (B-9: sc-13121, Santa Cruz Biotechnology; pH 6.0, 1:50), and FGFR4 (M00769-2, Boster Bio, USA; pH 6.0, 1:500).

Techniques: Over Expression, Amplification