Structured Review

Ipsen Group n type ca2 channel
N Type Ca2 Channel, supplied by Ipsen Group, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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n type ca2 channel - by Bioz Stars, 2021-06
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Related Articles

Sequencing:

Article Title: The Immediately Releasable Pool of Mouse Chromaffin Cell Vesicles Is Coupled to P/Q-Type Calcium Channels via the Synaptic Protein Interaction Site
Article Snippet: It should be noted that these authors induced exocytosis through relatively strong stimulation (i.e. trains of 200 ms depolarizations), and thus they did not specifically address the exocytosis of highly coupled vesicles. .. In summary, although it was shown previously that synprint is important in the establishment of Ca2+ channel-vesicle coupling in the mammalian presynapse and in reconstituted neurosecretory systems, to our knowledge we are the first to report that synprint sequence is critical for highly coupled IRP exocytosis in native chromaffin cells. .. Although the synprint sequence is also present in N-type Ca2+ channels, we showed in a previous study that our chromaffin cell preparation lacks N-type channels and hence our observed effects cannot be attributed to this channel type.

Binding Assay:

Article Title: Interaction of the synprint site of N-type Ca2+ channels with the C2B domain of synaptotagmin I
Article Snippet: In contrast, the blocking efficiency of the synprint peptide was maximal at low Ca2+ (10–20 μM), which is in the same range of Ca2+ concentration for maximal binding of N-type Ca2+ channels to syntaxin , and was reduced at higher concentration. .. The synprint peptide (0.5 μM) reduced synaptotagmin binding to syntaxin by approximately 50% at low Ca2+ or at 1 mM Ca2+ , but inhibited binding by approximately 90% at 10 μM and 80% at 20 μM, respectively. .. These results suggest that the increased affinity for binding of the synprint peptide for syntaxin in the presence of 10–20 μM Ca2+ ( ) results in the most efficient dissociation of the complex of syntaxin and synaptotagmin.

Article Title: Interaction of the synprint site of N-type Ca2+ channels with the C2B domain of synaptotagmin I
Article Snippet: Previous studies have shown that a complex of N-type Ca2+ channels, syntaxin, and synaptotagmin can be isolated from brain membranes ( , , ), suggesting that syntaxin can bind N-type Ca2+ channels and synaptotagmin at the same time. .. However, our results demonstrating competition between the Ca2+ channel synprint peptide and synaptotagmin for binding to syntaxin suggest that the ternary complex of Ca2+ channels, synaptotagmin, and syntaxin is not stable. .. Therefore, it is likely that these isolated preparations contained a mixture of binary complexes of N-type Ca2+ channels with either synaptotagmin or syntaxin bound to them, but not both.

other:

Article Title: Direct Interaction of a Brain Voltage-Gated K+Channel with Syntaxin 1A: Functional Impact on Channel Gating
Article Snippet: A number of other ion channels, including CFTR Cl− ( ; ) and epithelial Na+ channels ( ; ), were shown to interact physically and functionally with syntaxin 1A, a neuronal form of syntaxin.

Blocking Assay:

Article Title: Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase
Article Snippet: All of these molecular events are tightly regulated by intracellular Ca2+ concentration ([Ca2+ ]i ) and by the phosphorylation of the synprint sites on N-type and P/Q-type Cav channels (Yokoyama et al., ). .. By phosphorylation of the synprint site, GSK-3 decreases Ca2+ currents and Ca2+ influx in hippocampal neurons (Zhu et al., ), preventing the channel's association with SNAP25, syntaxin (Kim and Catterall, ; Yokoyama et al., , ), and synaptotagmin blocking presynaptic vesicle release (Zhu et al., ). .. This effect is remarkably similar to previously reported Cdk5/p25-dependent phosphorylation of the same II and III (LII−III ) loop of P/Q-type Cav channels, which also resulted in inhibition of the interaction of the channel with the SNARE complex required for neurotransmitter release (Tomizawa et al., ).

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    Ipsen Group n type ca2 channel
    N Type Ca2 Channel, supplied by Ipsen Group, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/n type ca2 channel/product/Ipsen Group
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    n type ca2 channel - by Bioz Stars, 2021-06
    86/100 stars
      Buy from Supplier

    86
    Ipsen Group n type ca2
    N Type Ca2, supplied by Ipsen Group, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/n type ca2/product/Ipsen Group
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    n type ca2 - by Bioz Stars, 2021-06
    86/100 stars
      Buy from Supplier

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