Structured Review

Ipsen Group n type ca2 channel
N Type Ca2 Channel, supplied by Ipsen Group, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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n type ca2 channel - by Bioz Stars, 2021-06
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Related Articles

Binding Assay:

Article Title: Interaction of the synprint site of N-type Ca2+ channels with the C2B domain of synaptotagmin I
Article Snippet: In contrast, the blocking efficiency of the synprint peptide was maximal at low Ca2+ (10–20 μM), which is in the same range of Ca2+ concentration for maximal binding of N-type Ca2+ channels to syntaxin , and was reduced at higher concentration. .. The synprint peptide (0.5 μM) reduced synaptotagmin binding to syntaxin by approximately 50% at low Ca2+ or at 1 mM Ca2+ , but inhibited binding by approximately 90% at 10 μM and 80% at 20 μM, respectively. .. These results suggest that the increased affinity for binding of the synprint peptide for syntaxin in the presence of 10–20 μM Ca2+ ( ) results in the most efficient dissociation of the complex of syntaxin and synaptotagmin.

Article Title: Interaction of the synprint site of N-type Ca2+ channels with the C2B domain of synaptotagmin I
Article Snippet: Previous studies have shown that a complex of N-type Ca2+ channels, syntaxin, and synaptotagmin can be isolated from brain membranes ( , , ), suggesting that syntaxin can bind N-type Ca2+ channels and synaptotagmin at the same time. .. However, our results demonstrating competition between the Ca2+ channel synprint peptide and synaptotagmin for binding to syntaxin suggest that the ternary complex of Ca2+ channels, synaptotagmin, and syntaxin is not stable. .. Therefore, it is likely that these isolated preparations contained a mixture of binary complexes of N-type Ca2+ channels with either synaptotagmin or syntaxin bound to them, but not both.

Blocking Assay:

Article Title: Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase
Article Snippet: All of these molecular events are tightly regulated by intracellular Ca2+ concentration ([Ca2+ ]i ) and by the phosphorylation of the synprint sites on N-type and P/Q-type Cav channels (Yokoyama et al., ). .. By phosphorylation of the synprint site, GSK-3 decreases Ca2+ currents and Ca2+ influx in hippocampal neurons (Zhu et al., ), preventing the channel's association with SNAP25, syntaxin (Kim and Catterall, ; Yokoyama et al., , ), and synaptotagmin blocking presynaptic vesicle release (Zhu et al., ). .. This effect is remarkably similar to previously reported Cdk5/p25-dependent phosphorylation of the same II and III (LII−III ) loop of P/Q-type Cav channels, which also resulted in inhibition of the interaction of the channel with the SNARE complex required for neurotransmitter release (Tomizawa et al., ).

Functional Assay:

Article Title: Molecular interactions of the plasma membrane calcium ATPase PMCA2 at pre- and post-synaptic sites in rat cerebellum
Article Snippet: However, we are confident that our results are not false positives for a number of reasons: (i) we carried out immunoprecipitations using magnetic beads rather than agarose or sepharose resins, (ii) if the syntaxin was binding to the beads directly we would have detected it in control immunoprecipitations using IgG in place of the precipitating antibody, and (iii) the reciprocal immunoprecipitation using anti syntaxin to co-precipitate PMCA would have yielded negative results had the syntaxin simply bound to the beads. .. At a functional level we could detect the PMCA2-syntaxin interaction in all regions of the cerebellar cortex characterized by a high density of synaptic terminals, although it was greatest in the granule cell layer. .. Syntaxin-1A binds to L-, N- and P/Q-type voltage-gated Ca2+ channels and influences the location and gating of these important channels; with obvious importance for the regulation of Ca2+ influx and subsequent neurotransmitter release (Sheng et al ., 1994; ; ).

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    Ipsen Group n type ca2 channel
    N Type Ca2 Channel, supplied by Ipsen Group, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Ipsen Group 1a co expression reduced current amplitudes
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    Ipsen Group ca2 influx
    Ca2 Influx, supplied by Ipsen Group, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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