metal nanoparticles  (Nanografi Advanced Materials)

Journal: International Journal of Nanomedicine

Article Title: Advancements in Nanocarrier Delivery Systems for Photodynamic Therapy in Lung Cancer

doi: 10.2147/IJN.S521444

Figure Lengend Snippet: Illustration of near-infrared region II (NIR-II) photo-accelerated polymer nanoparticle (PPNP) enhancing tumor immunotherapy via Programmed Death-Ligand 1 (PD-L1) silencing and immunogenic cell death (ICD). ( a ) The preparation of PPNP/siRNA. ( b ) Upon activation by 808 nm laser and overexpressed GSH, PPNP/siRNA will undergo cleavage, releasing both the NIR-II PS and siPD-L1. ROS production will be stimulated, leading to tumor ICD, the release of damage-associated molecular patterns (DAMPs), recruitment of T cells to lymph nodes, activation of T cells, and initiation of T cell immune responses. Simultaneously, the released siPD-L1 will inhibit PD-L1 activity on tumor cells, enhance phagocytosis of tumor cells by T cells, activate systemic anti-tumor immune responses, and ultimately reshape the immune microenvironment. This photo-accelerated immunotherapy strategy facilitates tumor-specific immune responses and remodeling of the TME. Reprinted from Zhang T, Tang D, Wu P, et al. NIR-II photo-accelerated polymer nanoparticles boost tumor immunotherapy via PD-L1 silencing andimmunogenic cell death. Bioact Mater . 2025;46:285–300.

Article Snippet: Inorganic Nanocarrier Systems , Metal Nanoparticles , Exhibit surface plasmon resonance effects, enhancing light absorption efficiency. Dual-functional agents for both PTT and PDT, providing better therapeutic efficacy. , [ , ] .

Techniques: Polymer, Activation Assay, Activity Assay