Structured Review

Millipore mefloquine hydrochloride
(A) Timeline of drug treatments, infections, and sample collection. C57BL/6 mice were injected intravenously with 500 GFP-expressing P. berghei sporozoites. Metformin (500 mg/kg/d) was provided in the drinking water 1 week before and during infection. Primaquine (PQ, 15 mg/kg) was injected 1 time intraperitoneally 2 hours after infection. <t>Mefloquine</t> (MQ, 10 mg/kg) was given daily by intraperitoneal injection. (B and C) Scatter plot showing the percentage of infected erythrocytes (parasitemia) measured by flow cytometry at day 3 (72 hours, B) and day 5 (C) after infection. Each dot represents 1 animal. The horizontal bar represents the mean. The total number of mice analyzed is as follows: 10, CTL; 10, MET; 10, PQ; 10, MET/PQ; 5, MQ; and 5, MET/MQ. P values calculated relative to nontreated CTL (B) and relative to MET (C). Ordinary 1-way ANOVA test, ****P < 0.0001; **P < 0.01; *P < 0.05; ns, not significant.
Mefloquine Hydrochloride, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mefloquine hydrochloride/product/Millipore
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
mefloquine hydrochloride - by Bioz Stars, 2023-01
86/100 stars

Images

1) Product Images from "Targeting liver stage malaria with metformin"

Article Title: Targeting liver stage malaria with metformin

Journal: JCI Insight

doi: 10.1172/jci.insight.127441

(A) Timeline of drug treatments, infections, and sample collection. C57BL/6 mice were injected intravenously with 500 GFP-expressing P. berghei sporozoites. Metformin (500 mg/kg/d) was provided in the drinking water 1 week before and during infection. Primaquine (PQ, 15 mg/kg) was injected 1 time intraperitoneally 2 hours after infection. Mefloquine (MQ, 10 mg/kg) was given daily by intraperitoneal injection. (B and C) Scatter plot showing the percentage of infected erythrocytes (parasitemia) measured by flow cytometry at day 3 (72 hours, B) and day 5 (C) after infection. Each dot represents 1 animal. The horizontal bar represents the mean. The total number of mice analyzed is as follows: 10, CTL; 10, MET; 10, PQ; 10, MET/PQ; 5, MQ; and 5, MET/MQ. P values calculated relative to nontreated CTL (B) and relative to MET (C). Ordinary 1-way ANOVA test, ****P < 0.0001; **P < 0.01; *P < 0.05; ns, not significant.
Figure Legend Snippet: (A) Timeline of drug treatments, infections, and sample collection. C57BL/6 mice were injected intravenously with 500 GFP-expressing P. berghei sporozoites. Metformin (500 mg/kg/d) was provided in the drinking water 1 week before and during infection. Primaquine (PQ, 15 mg/kg) was injected 1 time intraperitoneally 2 hours after infection. Mefloquine (MQ, 10 mg/kg) was given daily by intraperitoneal injection. (B and C) Scatter plot showing the percentage of infected erythrocytes (parasitemia) measured by flow cytometry at day 3 (72 hours, B) and day 5 (C) after infection. Each dot represents 1 animal. The horizontal bar represents the mean. The total number of mice analyzed is as follows: 10, CTL; 10, MET; 10, PQ; 10, MET/PQ; 5, MQ; and 5, MET/MQ. P values calculated relative to nontreated CTL (B) and relative to MET (C). Ordinary 1-way ANOVA test, ****P < 0.0001; **P < 0.01; *P < 0.05; ns, not significant.

Techniques Used: Injection, Expressing, Infection, Flow Cytometry


Structured Review

Millipore mefloquine hydrochloride
(A) Timeline of drug treatments, infections, and sample collection. C57BL/6 mice were injected intravenously with 500 GFP-expressing P. berghei sporozoites. Metformin (500 mg/kg/d) was provided in the drinking water 1 week before and during infection. Primaquine (PQ, 15 mg/kg) was injected 1 time intraperitoneally 2 hours after infection. <t>Mefloquine</t> (MQ, 10 mg/kg) was given daily by intraperitoneal injection. (B and C) Scatter plot showing the percentage of infected erythrocytes (parasitemia) measured by flow cytometry at day 3 (72 hours, B) and day 5 (C) after infection. Each dot represents 1 animal. The horizontal bar represents the mean. The total number of mice analyzed is as follows: 10, CTL; 10, MET; 10, PQ; 10, MET/PQ; 5, MQ; and 5, MET/MQ. P values calculated relative to nontreated CTL (B) and relative to MET (C). Ordinary 1-way ANOVA test, ****P < 0.0001; **P < 0.01; *P < 0.05; ns, not significant.
Mefloquine Hydrochloride, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mefloquine hydrochloride/product/Millipore
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
mefloquine hydrochloride - by Bioz Stars, 2023-01
86/100 stars

Images

1) Product Images from "Targeting liver stage malaria with metformin"

Article Title: Targeting liver stage malaria with metformin

Journal: JCI Insight

doi: 10.1172/jci.insight.127441

(A) Timeline of drug treatments, infections, and sample collection. C57BL/6 mice were injected intravenously with 500 GFP-expressing P. berghei sporozoites. Metformin (500 mg/kg/d) was provided in the drinking water 1 week before and during infection. Primaquine (PQ, 15 mg/kg) was injected 1 time intraperitoneally 2 hours after infection. Mefloquine (MQ, 10 mg/kg) was given daily by intraperitoneal injection. (B and C) Scatter plot showing the percentage of infected erythrocytes (parasitemia) measured by flow cytometry at day 3 (72 hours, B) and day 5 (C) after infection. Each dot represents 1 animal. The horizontal bar represents the mean. The total number of mice analyzed is as follows: 10, CTL; 10, MET; 10, PQ; 10, MET/PQ; 5, MQ; and 5, MET/MQ. P values calculated relative to nontreated CTL (B) and relative to MET (C). Ordinary 1-way ANOVA test, ****P < 0.0001; **P < 0.01; *P < 0.05; ns, not significant.
Figure Legend Snippet: (A) Timeline of drug treatments, infections, and sample collection. C57BL/6 mice were injected intravenously with 500 GFP-expressing P. berghei sporozoites. Metformin (500 mg/kg/d) was provided in the drinking water 1 week before and during infection. Primaquine (PQ, 15 mg/kg) was injected 1 time intraperitoneally 2 hours after infection. Mefloquine (MQ, 10 mg/kg) was given daily by intraperitoneal injection. (B and C) Scatter plot showing the percentage of infected erythrocytes (parasitemia) measured by flow cytometry at day 3 (72 hours, B) and day 5 (C) after infection. Each dot represents 1 animal. The horizontal bar represents the mean. The total number of mice analyzed is as follows: 10, CTL; 10, MET; 10, PQ; 10, MET/PQ; 5, MQ; and 5, MET/MQ. P values calculated relative to nontreated CTL (B) and relative to MET (C). Ordinary 1-way ANOVA test, ****P < 0.0001; **P < 0.01; *P < 0.05; ns, not significant.

Techniques Used: Injection, Expressing, Infection, Flow Cytometry


Structured Review

Millipore mefloquine plasma protein
Table 2
Mefloquine Plasma Protein, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mefloquine plasma protein/product/Millipore
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
mefloquine plasma protein - by Bioz Stars, 2023-01
86/100 stars

Images

1) Product Images from "Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice"

Article Title: Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice

Journal:

doi: 10.1038/sj.bjp.0705721

Table 2
Figure Legend Snippet: Table 2

Techniques Used:


Structured Review

Millipore mefloquine mefloquine plasma protein
Table 2
Mefloquine Mefloquine Plasma Protein, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mefloquine mefloquine plasma protein/product/Millipore
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
mefloquine mefloquine plasma protein - by Bioz Stars, 2023-01
86/100 stars

Images

1) Product Images from "Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice"

Article Title: Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice

Journal:

doi: 10.1038/sj.bjp.0705721

Table 2
Figure Legend Snippet: Table 2

Techniques Used:

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    Millipore mefloquine hydrochloride
    (A) Timeline of drug treatments, infections, and sample collection. C57BL/6 mice were injected intravenously with 500 GFP-expressing P. berghei sporozoites. Metformin (500 mg/kg/d) was provided in the drinking water 1 week before and during infection. Primaquine (PQ, 15 mg/kg) was injected 1 time intraperitoneally 2 hours after infection. <t>Mefloquine</t> (MQ, 10 mg/kg) was given daily by intraperitoneal injection. (B and C) Scatter plot showing the percentage of infected erythrocytes (parasitemia) measured by flow cytometry at day 3 (72 hours, B) and day 5 (C) after infection. Each dot represents 1 animal. The horizontal bar represents the mean. The total number of mice analyzed is as follows: 10, CTL; 10, MET; 10, PQ; 10, MET/PQ; 5, MQ; and 5, MET/MQ. P values calculated relative to nontreated CTL (B) and relative to MET (C). Ordinary 1-way ANOVA test, ****P < 0.0001; **P < 0.01; *P < 0.05; ns, not significant.
    Mefloquine Hydrochloride, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mefloquine hydrochloride/product/Millipore
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mefloquine hydrochloride - by Bioz Stars, 2023-01
    86/100 stars
      Buy from Supplier

    86
    Millipore mefloquine plasma protein
    Table 2
    Mefloquine Plasma Protein, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mefloquine plasma protein/product/Millipore
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mefloquine plasma protein - by Bioz Stars, 2023-01
    86/100 stars
      Buy from Supplier

    86
    Millipore mefloquine mefloquine plasma protein
    Table 2
    Mefloquine Mefloquine Plasma Protein, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mefloquine mefloquine plasma protein/product/Millipore
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mefloquine mefloquine plasma protein - by Bioz Stars, 2023-01
    86/100 stars
      Buy from Supplier

    Image Search Results


    (A) Timeline of drug treatments, infections, and sample collection. C57BL/6 mice were injected intravenously with 500 GFP-expressing P. berghei sporozoites. Metformin (500 mg/kg/d) was provided in the drinking water 1 week before and during infection. Primaquine (PQ, 15 mg/kg) was injected 1 time intraperitoneally 2 hours after infection. Mefloquine (MQ, 10 mg/kg) was given daily by intraperitoneal injection. (B and C) Scatter plot showing the percentage of infected erythrocytes (parasitemia) measured by flow cytometry at day 3 (72 hours, B) and day 5 (C) after infection. Each dot represents 1 animal. The horizontal bar represents the mean. The total number of mice analyzed is as follows: 10, CTL; 10, MET; 10, PQ; 10, MET/PQ; 5, MQ; and 5, MET/MQ. P values calculated relative to nontreated CTL (B) and relative to MET (C). Ordinary 1-way ANOVA test, ****P < 0.0001; **P < 0.01; *P < 0.05; ns, not significant.

    Journal: JCI Insight

    Article Title: Targeting liver stage malaria with metformin

    doi: 10.1172/jci.insight.127441

    Figure Lengend Snippet: (A) Timeline of drug treatments, infections, and sample collection. C57BL/6 mice were injected intravenously with 500 GFP-expressing P. berghei sporozoites. Metformin (500 mg/kg/d) was provided in the drinking water 1 week before and during infection. Primaquine (PQ, 15 mg/kg) was injected 1 time intraperitoneally 2 hours after infection. Mefloquine (MQ, 10 mg/kg) was given daily by intraperitoneal injection. (B and C) Scatter plot showing the percentage of infected erythrocytes (parasitemia) measured by flow cytometry at day 3 (72 hours, B) and day 5 (C) after infection. Each dot represents 1 animal. The horizontal bar represents the mean. The total number of mice analyzed is as follows: 10, CTL; 10, MET; 10, PQ; 10, MET/PQ; 5, MQ; and 5, MET/MQ. P values calculated relative to nontreated CTL (B) and relative to MET (C). Ordinary 1-way ANOVA test, ****P < 0.0001; **P < 0.01; *P < 0.05; ns, not significant.

    Article Snippet: Metformin (catalog D150959), Metformin-(dimethyl-d6) hydrochloride (catalog 53183), primaquine bisphosphate (catalog 160393), and mefloquine hydrochloride (catalog M2319) were purchased from MilliporeSigma.

    Techniques: Injection, Expressing, Infection, Flow Cytometry

    Table 2

    Journal:

    Article Title: Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice

    doi: 10.1038/sj.bjp.0705721

    Figure Lengend Snippet: Table 2

    Article Snippet: Mefloquine plasma protein-bound fraction was determined by ultrafiltration using Centrifree® devices (Millipore Corp., Bedford, U.S.A.).

    Techniques:

    Table 2

    Journal:

    Article Title: Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice

    doi: 10.1038/sj.bjp.0705721

    Figure Lengend Snippet: Table 2

    Article Snippet: Influence of elacridar on the plasma protein binding of mefloquine Mefloquine plasma protein-bound fraction was determined by ultrafiltration using Centrifree® devices (Millipore Corp., Bedford, U.S.A.).

    Techniques: