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lopinavir ritonavir  (Roche)


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    Structured Review

    Roche lopinavir ritonavir
    Lopinavir Ritonavir, supplied by Roche, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lopinavir ritonavir/product/Roche
    Average 86 stars, based on 1 article reviews
    lopinavir ritonavir - by Bioz Stars, 2025-02
    86/100 stars

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    AbbVie Inc lopinavir and ritonavir
    3CLpro inhibitors of SARS-CoV-2. Column headings include the molecule name, structure, IC 50 , K i , CC 50 , EC 50 , and reference, representing the structural name, structural representation, half-maximal inhibitory concentration, inhibition constant, half-maximal cytotoxic concentration, half-maximal effective concentration against SARS-CoV-2 (that were propagated and tittered in Vero-E6 cells), and the respective reference for the provided data. The physical chemistry parameters MW, TPSA, HDA, HBD, and consensus Log P were estimated from the SwissADME website [ <xref ref-type= 85 , 86 ]." width="250" height="auto" />
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    Image Search Results


    SEDDSs products in the clinic.

    Journal: Acta Pharmaceutica Sinica. B

    Article Title: Solubilization techniques used for poorly water-soluble drugs

    doi: 10.1016/j.apsb.2024.08.027

    Figure Lengend Snippet: SEDDSs products in the clinic.

    Article Snippet: Kaletra , Ritonavir Lopinavir , HIV infection , Polyoxyl 40 hydrogenated castor oil , AbbVie , 2000 , .

    Techniques: Transplantation Assay, Infection

    3CLpro inhibitors of SARS-CoV-2. Column headings include the molecule name, structure, IC 50 , K i , CC 50 , EC 50 , and reference, representing the structural name, structural representation, half-maximal inhibitory concentration, inhibition constant, half-maximal cytotoxic concentration, half-maximal effective concentration against SARS-CoV-2 (that were propagated and tittered in Vero-E6 cells), and the respective reference for the provided data. The physical chemistry parameters MW, TPSA, HDA, HBD, and consensus Log P were estimated from the SwissADME website [ <xref ref-type= 85 , 86 ]." width="100%" height="100%">

    Journal: Viruses

    Article Title: 3-Chymotrypsin-like Protease (3CLpro) of SARS-CoV-2: Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and Clinical Trials

    doi: 10.3390/v16060844

    Figure Lengend Snippet: 3CLpro inhibitors of SARS-CoV-2. Column headings include the molecule name, structure, IC 50 , K i , CC 50 , EC 50 , and reference, representing the structural name, structural representation, half-maximal inhibitory concentration, inhibition constant, half-maximal cytotoxic concentration, half-maximal effective concentration against SARS-CoV-2 (that were propagated and tittered in Vero-E6 cells), and the respective reference for the provided data. The physical chemistry parameters MW, TPSA, HDA, HBD, and consensus Log P were estimated from the SwissADME website [ 85 , 86 ].

    Article Snippet: Lopinavir and Ritonavir , Abbvie , Oral , Discontinued , 13,700.0 # , 26.6 * , NCT04381936.

    Techniques: Concentration Assay, Inhibition

    3CLpro inhibitors in preclinical and clinical trials. The table provides an overview of 3CLpro inhibitors in preclinical and clinical trials. Each row represents a specific molecule under investigation, with information about the 3CLpro inhibitors’ name, the pharmaceutical company responsible for their development, the route of administration, the current state of development, the inhibitory concentration (IC 50 ) in nanomolar for 3CLpro inhibitors in preclinical trials, the effective concentration (EC 50 ) in micromolar for 3CLpro inhibitors in preclinical or clinical trials, and the unique identifier (ID) of the registered clinical trial. These data offer a comprehensive perspective on 3CLpro inhibitors in the research and development phase for potential use in treating COVID-19.

    Journal: Viruses

    Article Title: 3-Chymotrypsin-like Protease (3CLpro) of SARS-CoV-2: Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and Clinical Trials

    doi: 10.3390/v16060844

    Figure Lengend Snippet: 3CLpro inhibitors in preclinical and clinical trials. The table provides an overview of 3CLpro inhibitors in preclinical and clinical trials. Each row represents a specific molecule under investigation, with information about the 3CLpro inhibitors’ name, the pharmaceutical company responsible for their development, the route of administration, the current state of development, the inhibitory concentration (IC 50 ) in nanomolar for 3CLpro inhibitors in preclinical trials, the effective concentration (EC 50 ) in micromolar for 3CLpro inhibitors in preclinical or clinical trials, and the unique identifier (ID) of the registered clinical trial. These data offer a comprehensive perspective on 3CLpro inhibitors in the research and development phase for potential use in treating COVID-19.

    Article Snippet: Lopinavir and Ritonavir , Abbvie , Oral , Discontinued , 13,700.0 # , 26.6 * , NCT04381936.

    Techniques: Concentration Assay