il 17c  (R&D Systems)

 
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    Name:
    Recombinant Human IL 17C CHO expressed Protein CF
    Description:
    The Recombinant Human IL 17C CHO expressed Protein from R D Systems is derived from CHO The Recombinant Human IL 17C CHO expressed Protein has been validated for the following applications Bioactivity
    Catalog Number:
    9640-IL-025/CF
    Price:
    329
    Category:
    Proteins and Enzymes
    Source:
    CHO-derived Recombinant Human IL-17C (CHO-expressed) Protein
    Applications:
    Bioactivity
    Purity:
    >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
    Conjugate:
    Unconjugated
    Size:
    25 ug
    Buy from Supplier


    Structured Review

    R&D Systems il 17c
    Recombinant Human IL 17C CHO expressed Protein CF
    The Recombinant Human IL 17C CHO expressed Protein from R D Systems is derived from CHO The Recombinant Human IL 17C CHO expressed Protein has been validated for the following applications Bioactivity
    https://www.bioz.com/result/il 17c/product/R&D Systems
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    il 17c - by Bioz Stars, 2021-09
    94/100 stars

    Images

    1) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    2) Product Images from "Regulation of intestinal inflammation and barrier function by IL-17C"

    Article Title: Regulation of intestinal inflammation and barrier function by IL-17C

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1103014

    Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per
    Figure Legend Snippet: Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per

    Techniques Used: Isolation, Real-time Polymerase Chain Reaction

    IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B
    Figure Legend Snippet: IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B

    Techniques Used: Expressing, Real-time Polymerase Chain Reaction

    IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as
    Figure Legend Snippet: IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as

    Techniques Used: Expressing, Quantitative RT-PCR, Derivative Assay

    3) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    4) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    5) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    6) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    7) Product Images from "Vesicular LL-37 Contributes to Inflammation of the Lesional Skin of Palmoplantar Pustulosis"

    Article Title: Vesicular LL-37 Contributes to Inflammation of the Lesional Skin of Palmoplantar Pustulosis

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0110677

    Cytokine induction in NHKs by the synthetic LL-37 peptide. To assess the ability of LL-37 to induce cytokines, NHKs were incubated with 3 µM LL-37 for 0, 2, 4, 8, 20, and 24 h at 37°C. (A) Expression levels of mRNAs encoding IL-17C, IL-8, IL-1α, and IL-1β mRNA, measured by qRT-PCR. The relative mRNA levels are expressed as means ±SDs (in -fold changes). Enzyme-linked immunoassays (ELISAs) were performed on culture media. All later values yielded by both qRT-PCR and ELISA were significantly different from those at 0 h (A, B, p
    Figure Legend Snippet: Cytokine induction in NHKs by the synthetic LL-37 peptide. To assess the ability of LL-37 to induce cytokines, NHKs were incubated with 3 µM LL-37 for 0, 2, 4, 8, 20, and 24 h at 37°C. (A) Expression levels of mRNAs encoding IL-17C, IL-8, IL-1α, and IL-1β mRNA, measured by qRT-PCR. The relative mRNA levels are expressed as means ±SDs (in -fold changes). Enzyme-linked immunoassays (ELISAs) were performed on culture media. All later values yielded by both qRT-PCR and ELISA were significantly different from those at 0 h (A, B, p

    Techniques Used: Incubation, Expressing, Quantitative RT-PCR, Enzyme-linked Immunosorbent Assay

    PPP vesicles stimulate expression of cytokine-encoding mRNAs in LSEs. PPP vesicles were suspended in 1% (w/v) agar and mRNAs measured using qRT-PCR. A) All of IL-17C (2.00±1.79-fold), IL-8 (1.8±1.7-fold), IL-1α (3.47±1.28-fold), and IL-1β (18.67±11.72-fold) were upregulated compared to the levels in non-treated LSEs (controls). The levels of cathelicidin, IL-8, IL-1α, and IL-1β differed significantly from those in control sweat. B) Western blotting showed that the hCAP-18/LL-37-depleted PPP-VF sample contained bands equivalent to hCAP-18 (18 kDa; full-length); an intermediate-sized fragment (∼14 kDa); mature LL-37 (4.5 kDa); and two additional bands (lane b). Lane a: the GST-hCAP18 peptide prior to incubation; Lane b: PPP-VF before depletion; Lane c: PPP-VF after depletion of endogenous hCAP-18/LL-37; Lane d: synthetic LL-37 peptide (3.2 pmol). C) mRNA expression levels in LSEs stimulated by original and depleted PPP-VF, as calculated via qRT-PCR. * p
    Figure Legend Snippet: PPP vesicles stimulate expression of cytokine-encoding mRNAs in LSEs. PPP vesicles were suspended in 1% (w/v) agar and mRNAs measured using qRT-PCR. A) All of IL-17C (2.00±1.79-fold), IL-8 (1.8±1.7-fold), IL-1α (3.47±1.28-fold), and IL-1β (18.67±11.72-fold) were upregulated compared to the levels in non-treated LSEs (controls). The levels of cathelicidin, IL-8, IL-1α, and IL-1β differed significantly from those in control sweat. B) Western blotting showed that the hCAP-18/LL-37-depleted PPP-VF sample contained bands equivalent to hCAP-18 (18 kDa; full-length); an intermediate-sized fragment (∼14 kDa); mature LL-37 (4.5 kDa); and two additional bands (lane b). Lane a: the GST-hCAP18 peptide prior to incubation; Lane b: PPP-VF before depletion; Lane c: PPP-VF after depletion of endogenous hCAP-18/LL-37; Lane d: synthetic LL-37 peptide (3.2 pmol). C) mRNA expression levels in LSEs stimulated by original and depleted PPP-VF, as calculated via qRT-PCR. * p

    Techniques Used: Expressing, Quantitative RT-PCR, Western Blot, Incubation

    8) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    9) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    10) Product Images from "Regulation of intestinal inflammation and barrier function by IL-17C"

    Article Title: Regulation of intestinal inflammation and barrier function by IL-17C

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1103014

    Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per
    Figure Legend Snippet: Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per

    Techniques Used: Isolation, Real-time Polymerase Chain Reaction

    IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B
    Figure Legend Snippet: IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B

    Techniques Used: Expressing, Real-time Polymerase Chain Reaction

    IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as
    Figure Legend Snippet: IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as

    Techniques Used: Expressing, Quantitative RT-PCR, Derivative Assay

    11) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    12) Product Images from "Regulation of intestinal inflammation and barrier function by IL-17C"

    Article Title: Regulation of intestinal inflammation and barrier function by IL-17C

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1103014

    Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per
    Figure Legend Snippet: Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per

    Techniques Used: Isolation, Real-time Polymerase Chain Reaction

    IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B
    Figure Legend Snippet: IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B

    Techniques Used: Expressing, Real-time Polymerase Chain Reaction

    IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as
    Figure Legend Snippet: IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as

    Techniques Used: Expressing, Quantitative RT-PCR, Derivative Assay

    13) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    14) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    15) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    16) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    17) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    18) Product Images from "Regulation of intestinal inflammation and barrier function by IL-17C"

    Article Title: Regulation of intestinal inflammation and barrier function by IL-17C

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1103014

    Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per
    Figure Legend Snippet: Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per

    Techniques Used: Isolation, Real-time Polymerase Chain Reaction

    IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B
    Figure Legend Snippet: IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B

    Techniques Used: Expressing, Real-time Polymerase Chain Reaction

    IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as
    Figure Legend Snippet: IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as

    Techniques Used: Expressing, Quantitative RT-PCR, Derivative Assay

    19) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    20) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    21) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    22) Product Images from "Regulation of intestinal inflammation and barrier function by IL-17C"

    Article Title: Regulation of intestinal inflammation and barrier function by IL-17C

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1103014

    Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per
    Figure Legend Snippet: Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per

    Techniques Used: Isolation, Real-time Polymerase Chain Reaction

    IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B
    Figure Legend Snippet: IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B

    Techniques Used: Expressing, Real-time Polymerase Chain Reaction

    IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as
    Figure Legend Snippet: IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as

    Techniques Used: Expressing, Quantitative RT-PCR, Derivative Assay

    23) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    24) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    25) Product Images from "Regulation of intestinal inflammation and barrier function by IL-17C"

    Article Title: Regulation of intestinal inflammation and barrier function by IL-17C

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1103014

    Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per
    Figure Legend Snippet: Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per

    Techniques Used: Isolation, Real-time Polymerase Chain Reaction

    IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B
    Figure Legend Snippet: IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B

    Techniques Used: Expressing, Real-time Polymerase Chain Reaction

    IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as
    Figure Legend Snippet: IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as

    Techniques Used: Expressing, Quantitative RT-PCR, Derivative Assay

    26) Product Images from "Regulation of intestinal inflammation and barrier function by IL-17C"

    Article Title: Regulation of intestinal inflammation and barrier function by IL-17C

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1103014

    Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per
    Figure Legend Snippet: Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per

    Techniques Used: Isolation, Real-time Polymerase Chain Reaction

    IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B
    Figure Legend Snippet: IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B

    Techniques Used: Expressing, Real-time Polymerase Chain Reaction

    IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as
    Figure Legend Snippet: IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as

    Techniques Used: Expressing, Quantitative RT-PCR, Derivative Assay

    27) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    28) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    29) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    30) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    31) Product Images from "IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations"

    Article Title: IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0243484

    Il-17c deletion decreases the expression of inflammatory cytokines. WT and Il-17c -/ - mice were exposed to heat-inactivated NTHi three times a week (day 1, 3, 5) for 4 weeks. Mice were analyzed 24 hours after the final exposure to NTHi. (A) Relative expression of IL-17C, IL-6, G-CSF, and KC in lung tissue (n = 5–6 mice per group). Data were compared by One-way ANOVA with Bonferroni post-test and are shown as the mean ± SD. **p
    Figure Legend Snippet: Il-17c deletion decreases the expression of inflammatory cytokines. WT and Il-17c -/ - mice were exposed to heat-inactivated NTHi three times a week (day 1, 3, 5) for 4 weeks. Mice were analyzed 24 hours after the final exposure to NTHi. (A) Relative expression of IL-17C, IL-6, G-CSF, and KC in lung tissue (n = 5–6 mice per group). Data were compared by One-way ANOVA with Bonferroni post-test and are shown as the mean ± SD. **p

    Techniques Used: Expressing, Mouse Assay

    IL-17C mediates chronic neutrophilic inflammation. WT and Il-17c -/- mice were exposed to heat-inactivated NTHi three times a week (day 1, 3, 5) for 4 weeks. Numbers of total immune cells (A), neutrophils (B), macrophages (C), and lymphocytes (D) were determined in BAL fluids 24 hours after the final exposure to NTHi (n = 6–7 per group). Data were compared by One-way ANOVA with Bonferroni post-test and are shown as the mean ± SD. *p
    Figure Legend Snippet: IL-17C mediates chronic neutrophilic inflammation. WT and Il-17c -/- mice were exposed to heat-inactivated NTHi three times a week (day 1, 3, 5) for 4 weeks. Numbers of total immune cells (A), neutrophils (B), macrophages (C), and lymphocytes (D) were determined in BAL fluids 24 hours after the final exposure to NTHi (n = 6–7 per group). Data were compared by One-way ANOVA with Bonferroni post-test and are shown as the mean ± SD. *p

    Techniques Used: Mouse Assay

    Negative correlation between IL-17C and IL-17E concentrations. Sputum was collected from COPD patients during AECOPD. Correlation of IL-17C with indicated cytokines was tested using nonparametric Spearman’s correlation test.
    Figure Legend Snippet: Negative correlation between IL-17C and IL-17E concentrations. Sputum was collected from COPD patients during AECOPD. Correlation of IL-17C with indicated cytokines was tested using nonparametric Spearman’s correlation test.

    Techniques Used:

    IL-17C does not contribute to CS-induced lung inflammation. WT and Il-17c -/- mice were exposed to CS for 4 weeks five times a week (days 1–5). Numbers of total immune cells (A), macrophages (B), neutrophils (C), and lymphocytes (D) were determined in BAL 24 hours after the final exposure to CS (n = 4–5 mice per group). Data were compared by unpaired Student’s t-test and are shown as the mean ± SD. *p
    Figure Legend Snippet: IL-17C does not contribute to CS-induced lung inflammation. WT and Il-17c -/- mice were exposed to CS for 4 weeks five times a week (days 1–5). Numbers of total immune cells (A), macrophages (B), neutrophils (C), and lymphocytes (D) were determined in BAL 24 hours after the final exposure to CS (n = 4–5 mice per group). Data were compared by unpaired Student’s t-test and are shown as the mean ± SD. *p

    Techniques Used: Mouse Assay

    Reduced lung damage in mice deficient for IL-17C. WT and Il-17c -/- mice were exposed to heat-inactivated NTHi three times a week (day 1, 3, 5) for 4 weeks. Mice were analyzed 24 hours after the final exposure to NTHi. Representative IHC of Ly6B (A) and CD3 (B) and quantification of the Ly6B + and CD3 + cells in lung parenchyma (n = 6 mice per group, 6–8 fields per mouse, Scale bar: 50 μm). Representative lung histology (C, hematoxylin and eosin staining) and inflammatory score (D) (n = 9–10 per group, 2–3 lung sections per mouse, scale bar: 100 μm). Data were compared by unpaired Student’s t-test and are shown as the mean ± SD. *p
    Figure Legend Snippet: Reduced lung damage in mice deficient for IL-17C. WT and Il-17c -/- mice were exposed to heat-inactivated NTHi three times a week (day 1, 3, 5) for 4 weeks. Mice were analyzed 24 hours after the final exposure to NTHi. Representative IHC of Ly6B (A) and CD3 (B) and quantification of the Ly6B + and CD3 + cells in lung parenchyma (n = 6 mice per group, 6–8 fields per mouse, Scale bar: 50 μm). Representative lung histology (C, hematoxylin and eosin staining) and inflammatory score (D) (n = 9–10 per group, 2–3 lung sections per mouse, scale bar: 100 μm). Data were compared by unpaired Student’s t-test and are shown as the mean ± SD. *p

    Techniques Used: Mouse Assay, Immunohistochemistry, Staining

    IL-17C contributes to acute COPD-like lung inflammation. WT and Il-17c -/- mice were exposed to NTHi (day 1, 3, and 5) or the combination of NTHi (day 1, 3, 5) and CS (day 1 to 5). Numbers of total immune cells (A), neutrophils (B), macrophages (C), and lymphocytes (D) were determined in BAL fluids 24 hours after the final exposure to NTHi (n = 7 per group). Concentrations G-CSF (E), MIP-2 (F), and KC (G) were measured in lung homogenate (n = 4–7 mice per group). Data were compared by One-way ANOVA with Bonferroni post-test and are shown as the mean ± SD. *p
    Figure Legend Snippet: IL-17C contributes to acute COPD-like lung inflammation. WT and Il-17c -/- mice were exposed to NTHi (day 1, 3, and 5) or the combination of NTHi (day 1, 3, 5) and CS (day 1 to 5). Numbers of total immune cells (A), neutrophils (B), macrophages (C), and lymphocytes (D) were determined in BAL fluids 24 hours after the final exposure to NTHi (n = 7 per group). Concentrations G-CSF (E), MIP-2 (F), and KC (G) were measured in lung homogenate (n = 4–7 mice per group). Data were compared by One-way ANOVA with Bonferroni post-test and are shown as the mean ± SD. *p

    Techniques Used: Mouse Assay

    IL-17C concentrations are increased during advanced COPD. (A) Concentrations of IL-17A, IL-17C, and IL-17E in sputum collected from GOLD I/II and GOLD III/IV COPD patients during AECOPD. (B) Concentrations of IL-17C in sputum separated in male (m) and female (f) donors. Horizontal lines indicate mean values. (C) Association of IL-17C concentrations with FEV1 (%) predicted. Correlation analysis was performed using nonparametric Spearman’s correlation test.
    Figure Legend Snippet: IL-17C concentrations are increased during advanced COPD. (A) Concentrations of IL-17A, IL-17C, and IL-17E in sputum collected from GOLD I/II and GOLD III/IV COPD patients during AECOPD. (B) Concentrations of IL-17C in sputum separated in male (m) and female (f) donors. Horizontal lines indicate mean values. (C) Association of IL-17C concentrations with FEV1 (%) predicted. Correlation analysis was performed using nonparametric Spearman’s correlation test.

    Techniques Used:

    32) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    33) Product Images from "Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation"

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1201505

    Characterization of the immune cell infiltrate in K5-IL-17C mouse skin
    Figure Legend Snippet: Characterization of the immune cell infiltrate in K5-IL-17C mouse skin

    Techniques Used:

    Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity
    Figure Legend Snippet: Systemic inhibition of TNFα in K5-IL-17C mice leads to improvement in disease severity

    Techniques Used: Inhibition, Mouse Assay

    IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners
    Figure Legend Snippet: IL-17C and TNFα induce characteristic psoriasis-related transcriptome genes in both additive and synergistic manners

    Techniques Used:

    K5-IL-17C transgenic mice develop a psoriasiform skin phenotype
    Figure Legend Snippet: K5-IL-17C transgenic mice develop a psoriasiform skin phenotype

    Techniques Used: Transgenic Assay, Mouse Assay

    K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF
    Figure Legend Snippet: K5-IL-17C mouse skin has increases in dermal angiogenesis and VEGF

    Techniques Used:

    Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin
    Figure Legend Snippet: Psoriasis-related innate defense and cytokines/chemokines are increased in K5-IL-17C skin

    Techniques Used:

    IL-17C RNA and protein are increased in lesional psoriasis skin
    Figure Legend Snippet: IL-17C RNA and protein are increased in lesional psoriasis skin

    Techniques Used:

    34) Product Images from "Regulation of intestinal inflammation and barrier function by IL-17C"

    Article Title: Regulation of intestinal inflammation and barrier function by IL-17C

    Journal: Journal of immunology (Baltimore, Md. : 1950)

    doi: 10.4049/jimmunol.1103014

    Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per
    Figure Legend Snippet: Increased pro-inflammatory mediator production in IL-17C−/− colons. ( A ) Proximal, intermediate, and distal colon sections from DSS animals were pooled prior to mRNA isolation and gene quantification by real time PCR. n = 5 animals per

    Techniques Used: Isolation, Real-time Polymerase Chain Reaction

    IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B
    Figure Legend Snippet: IL-17C deficiency results in exacerbated DSS-induced colitis. ( A ) WT colon tissue samples were harvested from healthy animals (n = 4) or animals after 8 d DSS treatment (n = 16) and then analyzed for the expression of IL-17C mRNA by real time PCR. ( B

    Techniques Used: Expressing, Real-time Polymerase Chain Reaction

    IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as
    Figure Legend Snippet: IL-17C-IL-17RE signaling promotes tight junction protein expression. ( A ) YAMC cells were examined for IL-17RE expression by real-time RT-PCR. Bone marrow-derived dendritic cells (DC), naïve CD4+ T cells (nCD4), and Th17 cells were utilized as

    Techniques Used: Expressing, Quantitative RT-PCR, Derivative Assay

    Related Articles

    Enzyme-linked Immunosorbent Assay:

    Article Title: Calcipotriol/Betamethasone Dipropionate Foam Inhibits Th17 Cytokine Secretion and Improves Epidermal Barrier Markers in a Human Th17 Skin Inflammation Model
    Article Snippet: .. Cytokine AnalysisCytokine levels in culture supernatants were assessed using Meso Scale Discovery assay kits (Meso Scale Discovery Rockville, MD, USA) for IL-17AF (K151VYK-1), IL-17A and IL-17C (K15067L-1), and R & D enzyme-linked immunosorbent assay kits (R & D Systems, Minneapolis, MN, USAUK) for IL-17F (DY1335B) and IL-22 (D2200), following each manufacturer’s instructions. ..

    other:

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation
    Article Snippet: In psoriasis patients there is ~125-fold more IL-17C than IL-17A protein in lesional skin ( ) and IL-17C is localized principally to activated KCs ( ).

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation
    Article Snippet: These results demonstrate similar mRNA transcript abundance of IL-17A and IL-17C but also illustrate that IL-17C protein is the most highly expressed IL-17 family member found in human involved psoriasis skin ( , 1058 ± 133 pg/mg IL-17C vs. 8 ± 2 pg/mg IL-17A protein).

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation
    Article Snippet: Primary human KCs failed to respond poorly to IL-17C alone , however, the addition of sub-optimal TNFα (2ng/ml) lead to a significant induction of candidate genes previously identified to respond either synergistically or additively in response to IL-17A/TNFα( ) ( ) and known to contribute to psoriasis pathogenesis.

    Produced:

    Article Title: Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation
    Article Snippet: .. Moreover, IL-17C stimulation lead to increases in EC-derived pro-inflammatory cytokines, including TNFα ( ); and primary human KCs stimulated with both IL-17C and sub-threshold levels of TNFα produced significant increases in these, as well as other key innate defense, chemokine and pro-inflammatorycytokine transcripts ( ). ..

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    R&D Systems il 17a
    Neutrophils are reduced in the joints of Il17ra −/− mice and are unresponsive to direct stimulation with <t>IL-17A.</t> A, Number of neutrophils in the ankle joints of WT and Il17ra −/− mice on day 12 was determined by FACS analysis counting Ly6G + cells in relation to counting beads. Data are presented as mean ± SEM (n = 3 mice per group). One of three independent experiments is shown. B, Chemotaxis of freshly isolated murine bone marrow-derived neutrophils towards 100 nM LTB 4 and IL-17A (10 and 100 ng/ml) assessed using 24-well transwell assays. Data represent numbers of migrated neutrophils (n = 3 independently performed experiments). C, Chemotaxis of freshly isolated murine bone marrow-derived neutrophils towards LTB 4 (100 nM) MIP-2 (100 nM) and IL-17A (1, 10, 100, 1000 ng/ml) as well as their corresponding chemokinesis controls assessed using 96-well ChemoTx assays. Data are presented as chemotactic index (number of cells migrating to chemoattractant/number of cell migrating to medium control). Data shown are mean ± SEM (n = 4 independently performed experiments). D, Levels of IL-17RA and IL-17RC mRNA determined by qPCR on RNA isolated from murine FLS and freshly isolated bone marrow-derived neutrophils (n = 3 independently performed experiments). Data were compared by unpaired two-tailed Student's t test, ** = p
    Il 17a, supplied by R&D Systems, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    R&D Systems goat anti mouse il 17
    Tbet deficiency prevents induction of transplantation tolerance by combined co-stimulation blockade with persistent T17/Th2 skewing of alloantigen specific cytokine profile, and PMN, CD4, and <t>IL-17-producing</t> CD8 T cell infiltration. ( A ) Kaplan-Meier survival
    Goat Anti Mouse Il 17, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    R&D Systems il 17f
    Immunostaining for chemoattractant receptor CXCR1/IL-8RA and <t>IL-17F</t> in representative samples of prostates from C57BL/6J mice. IL-1 β (10 μg/kg) was i.v. injected in the tail vein. To proof pro-inflammatory ability of IL-1 β along
    Il 17f, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Neutrophils are reduced in the joints of Il17ra −/− mice and are unresponsive to direct stimulation with IL-17A. A, Number of neutrophils in the ankle joints of WT and Il17ra −/− mice on day 12 was determined by FACS analysis counting Ly6G + cells in relation to counting beads. Data are presented as mean ± SEM (n = 3 mice per group). One of three independent experiments is shown. B, Chemotaxis of freshly isolated murine bone marrow-derived neutrophils towards 100 nM LTB 4 and IL-17A (10 and 100 ng/ml) assessed using 24-well transwell assays. Data represent numbers of migrated neutrophils (n = 3 independently performed experiments). C, Chemotaxis of freshly isolated murine bone marrow-derived neutrophils towards LTB 4 (100 nM) MIP-2 (100 nM) and IL-17A (1, 10, 100, 1000 ng/ml) as well as their corresponding chemokinesis controls assessed using 96-well ChemoTx assays. Data are presented as chemotactic index (number of cells migrating to chemoattractant/number of cell migrating to medium control). Data shown are mean ± SEM (n = 4 independently performed experiments). D, Levels of IL-17RA and IL-17RC mRNA determined by qPCR on RNA isolated from murine FLS and freshly isolated bone marrow-derived neutrophils (n = 3 independently performed experiments). Data were compared by unpaired two-tailed Student's t test, ** = p

    Journal: PLoS ONE

    Article Title: IL-17RA Signaling Amplifies Antibody-Induced Arthritis

    doi: 10.1371/journal.pone.0026342

    Figure Lengend Snippet: Neutrophils are reduced in the joints of Il17ra −/− mice and are unresponsive to direct stimulation with IL-17A. A, Number of neutrophils in the ankle joints of WT and Il17ra −/− mice on day 12 was determined by FACS analysis counting Ly6G + cells in relation to counting beads. Data are presented as mean ± SEM (n = 3 mice per group). One of three independent experiments is shown. B, Chemotaxis of freshly isolated murine bone marrow-derived neutrophils towards 100 nM LTB 4 and IL-17A (10 and 100 ng/ml) assessed using 24-well transwell assays. Data represent numbers of migrated neutrophils (n = 3 independently performed experiments). C, Chemotaxis of freshly isolated murine bone marrow-derived neutrophils towards LTB 4 (100 nM) MIP-2 (100 nM) and IL-17A (1, 10, 100, 1000 ng/ml) as well as their corresponding chemokinesis controls assessed using 96-well ChemoTx assays. Data are presented as chemotactic index (number of cells migrating to chemoattractant/number of cell migrating to medium control). Data shown are mean ± SEM (n = 4 independently performed experiments). D, Levels of IL-17RA and IL-17RC mRNA determined by qPCR on RNA isolated from murine FLS and freshly isolated bone marrow-derived neutrophils (n = 3 independently performed experiments). Data were compared by unpaired two-tailed Student's t test, ** = p

    Article Snippet: In order to determine which of the genes downregulated in the ankles of Il17ra−/− mice might be directly regulated by IL-17RA signaling, murine fibroblast-like synoviocytes (FLS) were either left unstimulated or stimulated with 100 ng/ml IL-17A for 16 h. RNA was then isolated and gene expression assessed by qPCR.

    Techniques: Mouse Assay, FACS, Chemotaxis Assay, Isolation, Derivative Assay, Real-time Polymerase Chain Reaction, Two Tailed Test

    The antimicrobial peptide psoriasin (S100A7) mediates cytokine-dependent caspase regulation and IL-1β release by epidermal keratinocytes. A, E, Keratinocytes stimulated with IFNγ, IL-17A, transfected with dsDNA and indicated siRNA, and the psoriasin-dependent IL-1β release was analyzed by ELISA. Data represent mean + SEM, **, p

    Journal: PLoS ONE

    Article Title: Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation

    doi: 10.1371/journal.pone.0175153

    Figure Lengend Snippet: The antimicrobial peptide psoriasin (S100A7) mediates cytokine-dependent caspase regulation and IL-1β release by epidermal keratinocytes. A, E, Keratinocytes stimulated with IFNγ, IL-17A, transfected with dsDNA and indicated siRNA, and the psoriasin-dependent IL-1β release was analyzed by ELISA. Data represent mean + SEM, **, p

    Article Snippet: D, E, Regulation of NLRP3 and AIM2 in IFNγ- and IL-17A -stimulated keratinocytes analyzed by RTqPCR and normalized to β-actin.

    Techniques: Transfection, Enzyme-linked Immunosorbent Assay

    Vitamin D interferes with IL-1β release by epidermal keratinocytes and suppresses caspase-5 expression in epidermal keratinocytes in psoriasis. A, dsDNA-transfected keratinocytes stimulated with IFNγ, IL-17A, and the vitamin D-dependent IL-1β release was analyzed by ELISA, n = 4. B, Keratinocytes stimulated with IFNγ, IL-17A and vitamin D-dependent caspase-5 levels were detected by immunoblotting, n = 3. C, Vitamin D-dependent regulation of caspase-5 in keratinocytes stimulated with IFNγ, IL-17A and analyzed by RTqPCR and normalized to β-actin. Data represent mean + SEM *, p

    Journal: PLoS ONE

    Article Title: Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation

    doi: 10.1371/journal.pone.0175153

    Figure Lengend Snippet: Vitamin D interferes with IL-1β release by epidermal keratinocytes and suppresses caspase-5 expression in epidermal keratinocytes in psoriasis. A, dsDNA-transfected keratinocytes stimulated with IFNγ, IL-17A, and the vitamin D-dependent IL-1β release was analyzed by ELISA, n = 4. B, Keratinocytes stimulated with IFNγ, IL-17A and vitamin D-dependent caspase-5 levels were detected by immunoblotting, n = 3. C, Vitamin D-dependent regulation of caspase-5 in keratinocytes stimulated with IFNγ, IL-17A and analyzed by RTqPCR and normalized to β-actin. Data represent mean + SEM *, p

    Article Snippet: D, E, Regulation of NLRP3 and AIM2 in IFNγ- and IL-17A -stimulated keratinocytes analyzed by RTqPCR and normalized to β-actin.

    Techniques: Expressing, Transfection, Enzyme-linked Immunosorbent Assay

    IL-17A amplifies caspase-5 induction and controls NLRP1-mediated IL-1β release by epidermal keratinocytes. A-D, Regulation of IL-1β, caspase-1, caspase-5, NLRP1in IFNγ- and IL-17A -stimulated keratinocytes analyzed by RTqPCR and normalized to β-actin. Data represent mean + SEM of three independent experiments performed in triplicates *, p

    Journal: PLoS ONE

    Article Title: Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation

    doi: 10.1371/journal.pone.0175153

    Figure Lengend Snippet: IL-17A amplifies caspase-5 induction and controls NLRP1-mediated IL-1β release by epidermal keratinocytes. A-D, Regulation of IL-1β, caspase-1, caspase-5, NLRP1in IFNγ- and IL-17A -stimulated keratinocytes analyzed by RTqPCR and normalized to β-actin. Data represent mean + SEM of three independent experiments performed in triplicates *, p

    Article Snippet: D, E, Regulation of NLRP3 and AIM2 in IFNγ- and IL-17A -stimulated keratinocytes analyzed by RTqPCR and normalized to β-actin.

    Techniques:

    Tbet deficiency prevents induction of transplantation tolerance by combined co-stimulation blockade with persistent T17/Th2 skewing of alloantigen specific cytokine profile, and PMN, CD4, and IL-17-producing CD8 T cell infiltration. ( A ) Kaplan-Meier survival

    Journal: Proceedings of the National Academy of Sciences of the United States of America

    Article Title: Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells

    doi: 10.1073/pnas.0812538106

    Figure Lengend Snippet: Tbet deficiency prevents induction of transplantation tolerance by combined co-stimulation blockade with persistent T17/Th2 skewing of alloantigen specific cytokine profile, and PMN, CD4, and IL-17-producing CD8 T cell infiltration. ( A ) Kaplan-Meier survival

    Article Snippet: Frozen sections were used for immunofluorescence staining using goat anti-mouse IL-17 (R & D Systems), rat anti-Mouse CD4 and CD8 (both from BioExpress) as primary antibodies.

    Techniques: Transplantation Assay

    In vivo IL-17 neutralization inhibits rejection and facilitates allograft survival with combined co-stimulation blockade in Tbet KO recipients. ( A ) Fully mismatched cardiac allograft survival in Tbet KO recipients treated with CTLA4Ig+MR1 and anti-IL-17

    Journal: Proceedings of the National Academy of Sciences of the United States of America

    Article Title: Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells

    doi: 10.1073/pnas.0812538106

    Figure Lengend Snippet: In vivo IL-17 neutralization inhibits rejection and facilitates allograft survival with combined co-stimulation blockade in Tbet KO recipients. ( A ) Fully mismatched cardiac allograft survival in Tbet KO recipients treated with CTLA4Ig+MR1 and anti-IL-17

    Article Snippet: Frozen sections were used for immunofluorescence staining using goat anti-mouse IL-17 (R & D Systems), rat anti-Mouse CD4 and CD8 (both from BioExpress) as primary antibodies.

    Techniques: In Vivo, Neutralization

    Immunostaining for chemoattractant receptor CXCR1/IL-8RA and IL-17F in representative samples of prostates from C57BL/6J mice. IL-1 β (10 μg/kg) was i.v. injected in the tail vein. To proof pro-inflammatory ability of IL-1 β along

    Journal:

    Article Title: IL-1?-INDUCED POST-TRANSITION EFFECT OF NF-KAPPAB PROVIDES TIME-DEPENDENT WAVE OF SIGNALS FOR INITIAL PHASE OF INTRAPOSTATIC INFLAMMATION

    doi: 10.1002/pros.20916

    Figure Lengend Snippet: Immunostaining for chemoattractant receptor CXCR1/IL-8RA and IL-17F in representative samples of prostates from C57BL/6J mice. IL-1 β (10 μg/kg) was i.v. injected in the tail vein. To proof pro-inflammatory ability of IL-1 β along

    Article Snippet: The intraprostatic expression of chemokine receptors, adhesion molecules, surface cell markers, and interleukin in formalin-fixed paraffin-embedded prostate tissue was evaluated using the following markers: for chemokine receptors - CXCR1/IL-8RA (Santa Cruz Biotechnology, Santa Cruz, CA) and CXCR4 (R & D System, Minneapolis, MN); for adhesion molecules - VCAM1 (Santa Cruz); for neutrophils - NIMP-R14 (Santa Cruz); for mononuclear cells (MNC) - CD45 (R & D System); and for IL-17F - (R & D System).

    Techniques: Immunostaining, Mouse Assay, Injection

    Systemic administration of IL-1β induces multitype time-dependent behavior of intraprostatic chemoattractant receptors and IL-17F

    Journal:

    Article Title: IL-1?-INDUCED POST-TRANSITION EFFECT OF NF-KAPPAB PROVIDES TIME-DEPENDENT WAVE OF SIGNALS FOR INITIAL PHASE OF INTRAPOSTATIC INFLAMMATION

    doi: 10.1002/pros.20916

    Figure Lengend Snippet: Systemic administration of IL-1β induces multitype time-dependent behavior of intraprostatic chemoattractant receptors and IL-17F

    Article Snippet: The intraprostatic expression of chemokine receptors, adhesion molecules, surface cell markers, and interleukin in formalin-fixed paraffin-embedded prostate tissue was evaluated using the following markers: for chemokine receptors - CXCR1/IL-8RA (Santa Cruz Biotechnology, Santa Cruz, CA) and CXCR4 (R & D System, Minneapolis, MN); for adhesion molecules - VCAM1 (Santa Cruz); for neutrophils - NIMP-R14 (Santa Cruz); for mononuclear cells (MNC) - CD45 (R & D System); and for IL-17F - (R & D System).

    Techniques: