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Journal: Nature Communications
Article Title: Single-cell spatial metabolomics with cell-type specific protein profiling for tissue systems biology
doi: 10.1038/s41467-023-43917-5
Figure Lengend Snippet: a Unsupervised single cell clusters from protein profiles in human tonsil tissues. Created with Biorender.com. b Spatial projection of corresponding cell clusters from a). c The top expressed metabolite channels in regions inside and outside germinal centers across tonsil tissues from the differential analysis. d Comparison of single cell metabolite expression levels for identified mass channels. Left: The metabolite channels related to Glucose pathway and Cholesterol fragments. Middle: The metabolite channels related to amino acid fragments. Right: Bar graph of selected metabolite channels ( n = 31156 cells). Mann-Whitney-Wilcoxon test was two-sided with Bonferroni correction (****: p < =0.0001). All box plots with center lines showing the medians, boxes indicating the interquartile range, and whiskers indicating a maximum of 1.5 times the interquartile range beyond the box. e Metabolite channels related to identified lipid fragments. f Spatial projection of single-cell metabolite expression levels for selected metabolite channels.
Article Snippet: The
Techniques: Comparison, Expressing, MANN-WHITNEY