Journal: Antibiotics

Article Title: Synergic Effect of Phthalide Lactones and Fluconazole and Its New Analogues as a Factor Limiting the Use of Azole Drugs against Candidiasis

doi: 10.3390/antibiotics11111500

Figure Lengend Snippet: Experimentally determined fungistatic activity of fluconazole and lactones 2–4 and fluconazole analogues 5–15 derivative against Candida albicans ATCC 10231, C. albicans ATCC 2091, C. zeylanoides KKP 3528, and C. guilliermondii KKP 3390 ( a – e ). MIC values are in μg/mL. MIC 50 : the amount of fungistatic substance (in µg/mL) inhibiting yeast growth by 50%. MIC 90 : the amount of fungistatic substance (in µg/mL) inhibiting yeast growth by 90%.

Article Snippet: The synergistic effects of fluconazole ( 1 ) and three synthetic lactones identical to naturally occurring celery plants—3- n -butylphthalide ( 2 ), 3- n -butylidenephthalide ( 3 ), 3- n -butyl-4,5, 6,7—tetrahydrophthalide ( 4 )—against Candida albicans ATCC 10231, C. albicans ATCC 2091, C. guilliermondii KKP 3390 and two strains of C. albicans resistant to fluconazole, were compared with the activity of individual compounds separately.

Techniques: Activity Assay

Journal: Antibiotics

Article Title: Synergic Effect of Phthalide Lactones and Fluconazole and Its New Analogues as a Factor Limiting the Use of Azole Drugs against Candidiasis

doi: 10.3390/antibiotics11111500

Figure Lengend Snippet: Determination of the MIC in the combination and the FIC values* for the 2,3,4 phthalide lactones and fluconazole in Candida albicans ATCC 10231, C. albicans ATCC 2091, C. guilliermondii .

Article Snippet: The synergistic effects of fluconazole ( 1 ) and three synthetic lactones identical to naturally occurring celery plants—3- n -butylphthalide ( 2 ), 3- n -butylidenephthalide ( 3 ), 3- n -butyl-4,5, 6,7—tetrahydrophthalide ( 4 )—against Candida albicans ATCC 10231, C. albicans ATCC 2091, C. guilliermondii KKP 3390 and two strains of C. albicans resistant to fluconazole, were compared with the activity of individual compounds separately.

Techniques:

Journal: Antibiotics

Article Title: Synergic Effect of Phthalide Lactones and Fluconazole and Its New Analogues as a Factor Limiting the Use of Azole Drugs against Candidiasis

doi: 10.3390/antibiotics11111500

Figure Lengend Snippet: Comparison of MIC and FIC factors for selected azole derivatives and 3- n -butylphthalide against C. albicans ATCC 109231, C. albicans ATCC 2091, and C. guilliermondii KKP 3390.

Article Snippet: The synergistic effects of fluconazole ( 1 ) and three synthetic lactones identical to naturally occurring celery plants—3- n -butylphthalide ( 2 ), 3- n -butylidenephthalide ( 3 ), 3- n -butyl-4,5, 6,7—tetrahydrophthalide ( 4 )—against Candida albicans ATCC 10231, C. albicans ATCC 2091, C. guilliermondii KKP 3390 and two strains of C. albicans resistant to fluconazole, were compared with the activity of individual compounds separately.

Techniques:

Journal: Antibiotics

Article Title: Synergic Effect of Phthalide Lactones and Fluconazole and Its New Analogues as a Factor Limiting the Use of Azole Drugs against Candidiasis

doi: 10.3390/antibiotics11111500

Figure Lengend Snippet: Experimentally determined fungistatic activity of fluconazole and lactones 2–4 and fluconazole analogues 5–15 derivative against Candida albicans ATCC 10231, C. albicans ATCC 2091, C. zeylanoides KKP 3528, and C. guilliermondii KKP 3390 ( a – e ). MIC values are in μg/mL. MIC 50 : the amount of fungistatic substance (in µg/mL) inhibiting yeast growth by 50%. MIC 90 : the amount of fungistatic substance (in µg/mL) inhibiting yeast growth by 90%.

Article Snippet: Esterification with phenylacetic acid is favorable in the case of C. albicans ATCC 2091 alcohol 13 : MIC 50 128.43 µg/mL ester 7 : 82.90 µg/mL and alcohol 15 : MIC 50 170.59 ester 6 : 69.18 µg/mL, while for Candida zeylanoides KKP 3528 and Candida guilliermondii KKP 3390 opposite dependencies were observed.

Techniques: Activity Assay

Journal: Antibiotics

Article Title: Synergic Effect of Phthalide Lactones and Fluconazole and Its New Analogues as a Factor Limiting the Use of Azole Drugs against Candidiasis

doi: 10.3390/antibiotics11111500

Figure Lengend Snippet: Determination of the MIC in the combination and the FIC values* for the 2,3,4 phthalide lactones and fluconazole in Candida albicans ATCC 10231, C. albicans ATCC 2091, C. guilliermondii .

Article Snippet: Esterification with phenylacetic acid is favorable in the case of C. albicans ATCC 2091 alcohol 13 : MIC 50 128.43 µg/mL ester 7 : 82.90 µg/mL and alcohol 15 : MIC 50 170.59 ester 6 : 69.18 µg/mL, while for Candida zeylanoides KKP 3528 and Candida guilliermondii KKP 3390 opposite dependencies were observed.

Techniques:

Journal: Antibiotics

Article Title: Synergic Effect of Phthalide Lactones and Fluconazole and Its New Analogues as a Factor Limiting the Use of Azole Drugs against Candidiasis

doi: 10.3390/antibiotics11111500

Figure Lengend Snippet: Comparison of MIC and FIC factors for selected azole derivatives and 3- n -butylphthalide against C. albicans ATCC 109231, C. albicans ATCC 2091, and C. guilliermondii KKP 3390.

Article Snippet: Esterification with phenylacetic acid is favorable in the case of C. albicans ATCC 2091 alcohol 13 : MIC 50 128.43 µg/mL ester 7 : 82.90 µg/mL and alcohol 15 : MIC 50 170.59 ester 6 : 69.18 µg/mL, while for Candida zeylanoides KKP 3528 and Candida guilliermondii KKP 3390 opposite dependencies were observed.

Techniques:

Journal: Italian Journal of Food Safety

Article Title: Behavior of Listeria innocua during the manufacturing and pit-ripening of Formaggio di Fossa di Sogliano PDO cheese

doi: 10.4081/ijfs.2020.8552

Figure Lengend Snippet: Evolution of L. innocua and Mesophilic Lactic Acid Bacteria (LAB) counts (Log CFU/g), and of pH and a w values during cheese making and ripening of Formaggio di Fossa di Sogliano PDO cheeses experimentally contaminated. Values are mean of the three replicates samples ± standard deviation.

Article Snippet: Three L. innocua strains (one type strain: ATCC ® 3390 ™ and two wild strains belonging to IZSLER’s collection: Li 48775 isolated from milk and Li 39673/2 isolated from butter) were used to contaminate the pasteurized milk.

Techniques: