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Journal: Antioxidants
Article Title: Prenatal Melatonin Modulates Cardiovascular Function and Oxidative Stress in Guinea Pig Neonates Under Normoxic and Hypoxic Gestation
doi: 10.3390/antiox15020162
Figure Lengend Snippet: Melatonin alters oxidative balance during both normoxic and hypoxic gestations. Representative photographs ( A ) and protein levels of catalase (CAT; ( B )), glutathione peroxidase 1/2 (GPX1/2; ( C )), superoxide dismutase-1 (SOD1; ( D )), superoxide dismutase-2 (SOD2; ( E )) and hemeoxigenase-1 (HO-1; ( F )) in left ventricle from newborn guinea pigs exposed to gestational normoxia (N; red) or hypoxia (H; blue) and treated with vehicle or melatonin during gestation. In panel ( A ), the separated band corresponds to the loading control (LC), which was used to normalize all blots based on densitometry. Values are expressed as mean ± SEM. n = 5–6 independent samples (one per pup) per group. Data were analyzed using two-way ANOVA with FDR post hoc test. Significant differences ( q ≤ 0.05): * vs. normoxic-counterpart, # vs. vehicle-counterpart.
Article Snippet: Glutathione Peroxidase 1/2 ,
Techniques: Control