Structured Review

Bristol Myers glucophage
Boxplot indicating body weight change (black), lean mass change (gray), and fat mass change (white). Comparison between gliclazide and <t>metformin</t> group in body weight change ( P = 0.000), lean mass change ( P = 0.004), and fat mass change ( P = 0.000); comparison between gliclazide and acarbose group in body weight change ( P = 0.020), lean mass change ( P = 0.003), and fat mass change ( P = 0.453); and comparison between metformin and acarbose group in body weight change ( P = 0.000), lean mass change ( P = 0.872), and fat mass change ( P = 0.000) .
Glucophage, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 88/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/glucophage/product/Bristol Myers
Average 88 stars, based on 12 article reviews
Price from $9.99 to $1999.99
glucophage - by Bioz Stars, 2022-11
88/100 stars

Images

1) Product Images from "The Effects of Gliclazide, Metformin, and Acarbose on Body Composition in Patients with Newly Diagnosed Type 2 Diabetes Mellitus"

Article Title: The Effects of Gliclazide, Metformin, and Acarbose on Body Composition in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Journal: Current Therapeutic Research, Clinical and Experimental

doi: 10.1016/j.curtheres.2013.10.002

Boxplot indicating body weight change (black), lean mass change (gray), and fat mass change (white). Comparison between gliclazide and metformin group in body weight change ( P = 0.000), lean mass change ( P = 0.004), and fat mass change ( P = 0.000); comparison between gliclazide and acarbose group in body weight change ( P = 0.020), lean mass change ( P = 0.003), and fat mass change ( P = 0.453); and comparison between metformin and acarbose group in body weight change ( P = 0.000), lean mass change ( P = 0.872), and fat mass change ( P = 0.000) .
Figure Legend Snippet: Boxplot indicating body weight change (black), lean mass change (gray), and fat mass change (white). Comparison between gliclazide and metformin group in body weight change ( P = 0.000), lean mass change ( P = 0.004), and fat mass change ( P = 0.000); comparison between gliclazide and acarbose group in body weight change ( P = 0.020), lean mass change ( P = 0.003), and fat mass change ( P = 0.453); and comparison between metformin and acarbose group in body weight change ( P = 0.000), lean mass change ( P = 0.872), and fat mass change ( P = 0.000) .

Techniques Used:

2) Product Images from "Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus"

Article Title: Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus

Journal: BMC Pharmacology & Toxicology

doi: 10.1186/2050-6511-14-25

Fasting plasma glucose concentration (FPG; mmol/L) – Change from baseline (pre- dose on Day 1 of each treatment period). MET BID, metformin 500 mg every 12 hours; RE BID, remogliflozin etabonate 500 mg every 12 hours; MET + RE BID, metformin 500 mg + remogliflozin etabonate 500 mg every 12 hours. Mean (and standard deviation) baseline FPG values for each treatment period: MET BID: 6.72 (1.88); RE BID, 6.98 (2.06); MET + RE BID, 6.42 (1.15).
Figure Legend Snippet: Fasting plasma glucose concentration (FPG; mmol/L) – Change from baseline (pre- dose on Day 1 of each treatment period). MET BID, metformin 500 mg every 12 hours; RE BID, remogliflozin etabonate 500 mg every 12 hours; MET + RE BID, metformin 500 mg + remogliflozin etabonate 500 mg every 12 hours. Mean (and standard deviation) baseline FPG values for each treatment period: MET BID: 6.72 (1.88); RE BID, 6.98 (2.06); MET + RE BID, 6.42 (1.15).

Techniques Used: Concentration Assay, Standard Deviation

Median remogliflozin etabonate (prodrug) concentration vs. time profiles with and without metformin, n = 13. (Median data is presented in this plot because the majority of the samples were below the lower limit of quantification).
Figure Legend Snippet: Median remogliflozin etabonate (prodrug) concentration vs. time profiles with and without metformin, n = 13. (Median data is presented in this plot because the majority of the samples were below the lower limit of quantification).

Techniques Used: Concentration Assay

Mean remogliflozin (active entity) concentration (and standard deviation) vs. time profiles with and without metformin, n = 13.
Figure Legend Snippet: Mean remogliflozin (active entity) concentration (and standard deviation) vs. time profiles with and without metformin, n = 13.

Techniques Used: Concentration Assay, Standard Deviation

Mean GSK279782 (active metabolite) concentration (and standard deviation) vs. time profiles with and without metformin, n = 13.
Figure Legend Snippet: Mean GSK279782 (active metabolite) concentration (and standard deviation) vs. time profiles with and without metformin, n = 13.

Techniques Used: Concentration Assay, Standard Deviation

Lactic acid concentration by treatment (normal range of 0.5 to 2.2 mmol/L). MET BID, metformin 500 mg every 12 hours; RE BID, remogliflozin etabonate 500 mg every 12 hours; MET + RE BID, metformin 500 mg + remogliflozin etabonate 500 mg every 12 hours.
Figure Legend Snippet: Lactic acid concentration by treatment (normal range of 0.5 to 2.2 mmol/L). MET BID, metformin 500 mg every 12 hours; RE BID, remogliflozin etabonate 500 mg every 12 hours; MET + RE BID, metformin 500 mg + remogliflozin etabonate 500 mg every 12 hours.

Techniques Used: Concentration Assay

Mean metformin concentration (and standard deviation) vs. time profiles with and without remogliflozin etabonate, n = 13.
Figure Legend Snippet: Mean metformin concentration (and standard deviation) vs. time profiles with and without remogliflozin etabonate, n = 13.

Techniques Used: Concentration Assay, Standard Deviation

3) Product Images from "Patenting Carboxyformin in the United States: How Does It Work and What Does It Mean?"

Article Title: Patenting Carboxyformin in the United States: How Does It Work and What Does It Mean?

Journal: Journal of Diabetes Science and Technology

doi:

A side-by-side comparison of metformin and carboxyformin
Figure Legend Snippet: A side-by-side comparison of metformin and carboxyformin

Techniques Used:

Metformin.
Figure Legend Snippet: Metformin.

Techniques Used:

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    Bristol Myers metformin hydrochloride
    Metformin Hydrochloride, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/metformin hydrochloride/product/Bristol Myers
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    metformin hydrochloride - by Bioz Stars, 2022-11
    86/100 stars
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