Gene Exp Ptger2 Mm00436051 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "mPGES1-dependent PGE2 controls antigen-specific Th17 and Th1 responses by regulating T autocrine and paracrine PGE2 production"
Article Title: mPGES1-dependent PGE2 controls antigen-specific Th17 and Th1 responses by regulating T autocrine and paracrine PGE2 production
Journal: Journal of immunology (Baltimore, Md. : 1950)
Figure Legend Snippet: mPGES1 and ptger4 are strongly downregulated during Th17 polarization (A) Freshly isolated CD4 + T cells from naïve mice were sorted into the indicated naïve, memory and regulatory subsets (CD25 − CD44 − CD62L + , CD25 − CD44 + CD62L − and CD25 + ) and analyzed for their expression levels of ptger2 , ptger4 , tgfbr1 and il23r . All values are relative to the WT CD4 + CD25 + T cell population. (B) Expression levels kinetics of the indicated mRNAs were evaluated at the indicated time-points (freshly isolated, days 1, 2, 3 and 4) under Th17-polarizing conditions. Results are compiled from 3 different experiments with 3–4 pooled mice cells and 4 replicates. ** indicates a statistically significant difference (P
Techniques Used: Isolation, Mouse Assay, Expressing
2) Product Images from "Mechanical Induction of PGE2 in Osteocytes Blocks Glucocorticoid-Induced Apoptosis Through Both the ?-Catenin and PKA Pathways"
Article Title: Mechanical Induction of PGE2 in Osteocytes Blocks Glucocorticoid-Induced Apoptosis Through Both the ?-Catenin and PKA Pathways
Journal: Journal of Bone and Mineral Research
Figure Legend Snippet: A diagram showing the means whereby mechanical loading (ɛ) prevents apoptosis. Mechanical loading, in the form of FFSS, induces the release of prostaglandin (PGE 2 ) through connexin 43 hemichannels (Cx43 HCs), as shown previously by Cherian and colleagues( 32 ) to have both autocrine and paracrine effects through EP2 and EP4 receptors. These receptors not only signal through the traditional cAMP/PKA pathway to reduce apoptosis but also signal through the PI3k/Akt/GSK-3/β-catenin pathway. Lithium chloride (LiCl) also blocks apoptosis. The same mechanism and pathways were shown to be responsible for the transcription of Cx43 and increased gap junction function.( 25 ) For additional information on the potential for crosstalk between these two pathways and role in bone cell function, see the review by Bonewald and Johnson.( 60 )
Techniques Used: Cell Function Assay