e 205 3 116 2 z 124 1 79 1  (Merck & Co)

Journal: Clinical Mass Spectrometry

Article Title: Mass spectrometry for therapeutic drug monitoring of anti-tuberculosis drugs

doi: 10.1016/j.clinms.2018.10.002

Figure Lengend Snippet: Multi-analyte assays for first- and second-line anti-tuberculosis drugs and single -analyte assays for second-line drugs using LC-MS/MS.

Article Snippet: R, H, E, Z, S [47] , Phenacetin , >18 , 100, plasma , methanol, formic acid , Agilent, Zorbax SB-C18 (100 × 2.1 mm, 3.5 μm) , R, Z 0.2–4, H 0.08–2, E 0.0002–1, S 0.002–0.2 , A: 0.02% heptaflourobutyric acid, 0.2% formic acid in methanol B: 0.02% heptaflourobutyric acid, 0.2% formic acid in water pH: NA , 8.5 , R ca 7.2, H ca 1.3, E ca 1.6, Z ca 1.7, S ca 1.5 , R 823.4–791.2, H 138.1–120.9, E 205.3–116.2 Z 124.1–79.1, S 582.3–262.6.

Techniques: Hydrophilic Interaction Liquid Chromatography

Journal: Clinical Mass Spectrometry

Article Title: Mass spectrometry for therapeutic drug monitoring of anti-tuberculosis drugs

doi: 10.1016/j.clinms.2018.10.002

Figure Lengend Snippet: Multi-analyte assays for first- and second-line anti-tuberculosis drugs and single -analyte assays for second-line drugs using LC-MS/MS.

Article Snippet: 2 R 1.42, H 1.41, E 1.22, Z 1.64, S 1.11 R 823.7–791.6, H 138.1–121.1, E 205.3–116.2 Z 124.1–81.1, S 582.5–263.3 R, H, E, Z [46] , [43] 6,7-dimethyl-2,3-di(2-pyridyl)quioxaline (R), Thymidine (H, E, Z) >10 200, plasma acetonitrile Waters, Acquity HSS T3 (150 × 2.1 mm, 1.8 μm) R 0.47–60, H, E 0.12–15 Z 0.55–70 A: water with 0.05% formic acid B: acetonitrile with 0.05% formic acid pH: NA 6 R ca 4.4, H ca 1.6, E ca 0.8, Z ca 3.1 R 824–792, H 138–79, E 205–116, Z 124–81 R, H, E, Z, S [47] Phenacetin >18 100, plasma methanol, formic acid Agilent, Zorbax SB-C18 (100 × 2.1 mm, 3.5 μm) R, Z 0.2–4, H 0.08–2, E 0.0002–1, S 0.002–0.2 A: 0.02% heptaflourobutyric acid, 0.2% formic acid in methanol B: 0.02% heptaflourobutyric acid, 0.2% formic acid in water pH: NA 8.5 R ca 7.2, H ca 1.3, E ca 1.6, Z ca 1.7, S ca 1.5 R 823.4–791.2, H 138.1–120.9, E 205.3–116.2 Z 124.1–79.1, S 582.3–262.6 R, H, E, Z [50] D3-Rifampicin (R), D4-isoniazid (H) 15 N,D3-pyrazinamide (Z), D4-ethambutol dihydrochloride (E) >82 50, plasma methanol, acetonitrile Merck, Chromolith Flash RP-18e (25 × 4.6 mm, 2 μm) R 0.75–30, H 0.5–10, E 0.25–10, Z 4–80 A: 5 mM ammonium acetate, 5% methanol and 0.45% formic acid in water.

Techniques: Hydrophilic Interaction Liquid Chromatography