clusterin sirna reagents  (Santa Cruz Biotechnology)

 
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    Santa Cruz Biotechnology clusterin sirna reagents
    <t>Clusterin</t> underlies astrocyte endocytosis of Aβ in vitro. A Western blot of Bace1 -null and WT-primary astrocytes pretreated with either 80 pmol of Clu <t>siRNA</t> or 80 pmol of control scrambled siRNA and incubated with 2 μM of Aβ 42 for indicated times. Images indicate major bands for Aβ 42 (human, oligomeric) and GAPDH. B Quantification of Western blot Aβ 42 band intensity normalized to actin ( N = 3, * p -value < 0.05, ** p -value < 0.01, *** p -value < 0.001; One-way ANOVA with Tukey post testing comparing between samples. C Confocal imaging of astrocyte primary cultures from BACE1-null and WT and pretreated with either Clu or control scrambled siRNA then treated with 2 μM of Aβ 42 tagged with fluorescent Hilyte-555 for indicated incubation times. Stained with phalloidin (green) to mark F-actin and ToPro3 (blue) to mark nuclei. Scale bars represents 10 μm
    Clusterin Sirna Reagents, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/clusterin sirna reagents/product/Santa Cruz Biotechnology
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    clusterin sirna reagents - by Bioz Stars, 2024-09
    86/100 stars

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    1) Product Images from "BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides"

    Article Title: BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

    Journal: Molecular Neurodegeneration

    doi: 10.1186/s13024-023-00611-w

    Clusterin underlies astrocyte endocytosis of Aβ in vitro. A Western blot of Bace1 -null and WT-primary astrocytes pretreated with either 80 pmol of Clu siRNA or 80 pmol of control scrambled siRNA and incubated with 2 μM of Aβ 42 for indicated times. Images indicate major bands for Aβ 42 (human, oligomeric) and GAPDH. B Quantification of Western blot Aβ 42 band intensity normalized to actin ( N = 3, * p -value < 0.05, ** p -value < 0.01, *** p -value < 0.001; One-way ANOVA with Tukey post testing comparing between samples. C Confocal imaging of astrocyte primary cultures from BACE1-null and WT and pretreated with either Clu or control scrambled siRNA then treated with 2 μM of Aβ 42 tagged with fluorescent Hilyte-555 for indicated incubation times. Stained with phalloidin (green) to mark F-actin and ToPro3 (blue) to mark nuclei. Scale bars represents 10 μm
    Figure Legend Snippet: Clusterin underlies astrocyte endocytosis of Aβ in vitro. A Western blot of Bace1 -null and WT-primary astrocytes pretreated with either 80 pmol of Clu siRNA or 80 pmol of control scrambled siRNA and incubated with 2 μM of Aβ 42 for indicated times. Images indicate major bands for Aβ 42 (human, oligomeric) and GAPDH. B Quantification of Western blot Aβ 42 band intensity normalized to actin ( N = 3, * p -value < 0.05, ** p -value < 0.01, *** p -value < 0.001; One-way ANOVA with Tukey post testing comparing between samples. C Confocal imaging of astrocyte primary cultures from BACE1-null and WT and pretreated with either Clu or control scrambled siRNA then treated with 2 μM of Aβ 42 tagged with fluorescent Hilyte-555 for indicated incubation times. Stained with phalloidin (green) to mark F-actin and ToPro3 (blue) to mark nuclei. Scale bars represents 10 μm

    Techniques Used: In Vitro, Western Blot, Incubation, Imaging, Staining

    Differentially expressed genes in Bace1-deleted astrocytes
    Figure Legend Snippet: Differentially expressed genes in Bace1-deleted astrocytes

    Techniques Used: Binding Assay


    Figure Legend Snippet:

    Techniques Used:

    clusterin sirna reagents  (Santa Cruz Biotechnology)

     
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    Santa Cruz Biotechnology clusterin sirna reagents
    Clusterin Sirna Reagents, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/clusterin sirna reagents/product/Santa Cruz Biotechnology
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    clusterin sirna reagents - by Bioz Stars, 2024-09
    93/100 stars

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    clusterin sirna reagent system  (Santa Cruz Biotechnology)

     
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    Structured Review

    Santa Cruz Biotechnology clusterin sirna reagent system
    Clusterin Sirna Reagent System, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/clusterin sirna reagent system/product/Santa Cruz Biotechnology
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    clusterin sirna reagent system - by Bioz Stars, 2024-09
    86/100 stars

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    Santa Cruz Biotechnology clusterin sirna reagents
    <t>Clusterin</t> underlies astrocyte endocytosis of Aβ in vitro. A Western blot of Bace1 -null and WT-primary astrocytes pretreated with either 80 pmol of Clu <t>siRNA</t> or 80 pmol of control scrambled siRNA and incubated with 2 μM of Aβ 42 for indicated times. Images indicate major bands for Aβ 42 (human, oligomeric) and GAPDH. B Quantification of Western blot Aβ 42 band intensity normalized to actin ( N = 3, * p -value < 0.05, ** p -value < 0.01, *** p -value < 0.001; One-way ANOVA with Tukey post testing comparing between samples. C Confocal imaging of astrocyte primary cultures from BACE1-null and WT and pretreated with either Clu or control scrambled siRNA then treated with 2 μM of Aβ 42 tagged with fluorescent Hilyte-555 for indicated incubation times. Stained with phalloidin (green) to mark F-actin and ToPro3 (blue) to mark nuclei. Scale bars represents 10 μm
    Clusterin Sirna Reagents, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/clusterin sirna reagents/product/Santa Cruz Biotechnology
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    clusterin sirna reagents - by Bioz Stars, 2024-09
    86/100 stars
    		  Buy from Supplier
    clusterin sirna reagent system  (Santa Cruz Biotechnology)
    86
    Santa Cruz Biotechnology clusterin sirna reagent system
    <t>Clusterin</t> underlies astrocyte endocytosis of Aβ in vitro. A Western blot of Bace1 -null and WT-primary astrocytes pretreated with either 80 pmol of Clu <t>siRNA</t> or 80 pmol of control scrambled siRNA and incubated with 2 μM of Aβ 42 for indicated times. Images indicate major bands for Aβ 42 (human, oligomeric) and GAPDH. B Quantification of Western blot Aβ 42 band intensity normalized to actin ( N = 3, * p -value < 0.05, ** p -value < 0.01, *** p -value < 0.001; One-way ANOVA with Tukey post testing comparing between samples. C Confocal imaging of astrocyte primary cultures from BACE1-null and WT and pretreated with either Clu or control scrambled siRNA then treated with 2 μM of Aβ 42 tagged with fluorescent Hilyte-555 for indicated incubation times. Stained with phalloidin (green) to mark F-actin and ToPro3 (blue) to mark nuclei. Scale bars represents 10 μm
    Clusterin Sirna Reagent System, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/clusterin sirna reagent system/product/Santa Cruz Biotechnology
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    clusterin sirna reagent system - by Bioz Stars, 2024-09
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    Clusterin underlies astrocyte endocytosis of Aβ in vitro. A Western blot of Bace1 -null and WT-primary astrocytes pretreated with either 80 pmol of Clu siRNA or 80 pmol of control scrambled siRNA and incubated with 2 μM of Aβ 42 for indicated times. Images indicate major bands for Aβ 42 (human, oligomeric) and GAPDH. B Quantification of Western blot Aβ 42 band intensity normalized to actin ( N = 3, * p -value < 0.05, ** p -value < 0.01, *** p -value < 0.001; One-way ANOVA with Tukey post testing comparing between samples. C Confocal imaging of astrocyte primary cultures from BACE1-null and WT and pretreated with either Clu or control scrambled siRNA then treated with 2 μM of Aβ 42 tagged with fluorescent Hilyte-555 for indicated incubation times. Stained with phalloidin (green) to mark F-actin and ToPro3 (blue) to mark nuclei. Scale bars represents 10 μm

    Journal: Molecular Neurodegeneration

    Article Title: BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

    doi: 10.1186/s13024-023-00611-w

    Figure Lengend Snippet: Clusterin underlies astrocyte endocytosis of Aβ in vitro. A Western blot of Bace1 -null and WT-primary astrocytes pretreated with either 80 pmol of Clu siRNA or 80 pmol of control scrambled siRNA and incubated with 2 μM of Aβ 42 for indicated times. Images indicate major bands for Aβ 42 (human, oligomeric) and GAPDH. B Quantification of Western blot Aβ 42 band intensity normalized to actin ( N = 3, * p -value < 0.05, ** p -value < 0.01, *** p -value < 0.001; One-way ANOVA with Tukey post testing comparing between samples. C Confocal imaging of astrocyte primary cultures from BACE1-null and WT and pretreated with either Clu or control scrambled siRNA then treated with 2 μM of Aβ 42 tagged with fluorescent Hilyte-555 for indicated incubation times. Stained with phalloidin (green) to mark F-actin and ToPro3 (blue) to mark nuclei. Scale bars represents 10 μm

    Article Snippet: Knockdown of Clu in astrocyte cultures was attained by using Clusterin siRNA reagents (Santa Cruz Biotechnology, catalog no. sc-43689) or control scrambled siRNA (Santa Cruz Biotechnology, catalog no. sc-37007) according to manufacturer’s instructions.

    Techniques: In Vitro, Western Blot, Incubation, Imaging, Staining

    Differentially expressed genes in Bace1-deleted astrocytes

    Journal: Molecular Neurodegeneration

    Article Title: BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

    doi: 10.1186/s13024-023-00611-w

    Figure Lengend Snippet: Differentially expressed genes in Bace1-deleted astrocytes

    Article Snippet: Knockdown of Clu in astrocyte cultures was attained by using Clusterin siRNA reagents (Santa Cruz Biotechnology, catalog no. sc-43689) or control scrambled siRNA (Santa Cruz Biotechnology, catalog no. sc-37007) according to manufacturer’s instructions.

    Techniques: Binding Assay

    Journal: Molecular Neurodegeneration

    Article Title: BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

    doi: 10.1186/s13024-023-00611-w

    Figure Lengend Snippet:

    Article Snippet: Knockdown of Clu in astrocyte cultures was attained by using Clusterin siRNA reagents (Santa Cruz Biotechnology, catalog no. sc-43689) or control scrambled siRNA (Santa Cruz Biotechnology, catalog no. sc-37007) according to manufacturer’s instructions.

    Techniques: