chemodrug doxorubicin  (Millipore)


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    Structured Review

    Millipore chemodrug doxorubicin
    Blocking Src's metabolic effect sensitizes cancer cells to pro-oxidant chemotherapy A, B. Src inhibitors and <t>chemodrug</t> <t>Doxorubicin</t> (Dox) show additive/synergistic effects on ROS induction and suppression of cell growth/viability. 4T1 cells were treated with Dox (1 μg/ml) and Src inhibitors SA and SU (1 μM each). ROS levels (A) and cell growth and viability (B) were subsequently determined. C, D. Expression of PDHA1 Y289F sensitizes cells to pro-oxidant. 4T1 cells transduced with WT or Y289F PDHA1 were treated with vehicle (DMSO) or Dox, followed by measurement of ROS levels (C) and cell growth and survival (D). Error bars represent S.D. *p
    Chemodrug Doxorubicin, supplied by Millipore, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/chemodrug doxorubicin/product/Millipore
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    chemodrug doxorubicin - by Bioz Stars, 2020-04
    91/100 stars

    Related Products / Commonly Used Together

    su6656
    saracatinib
    src inhibitors pp2

    Images

    1) Product Images from "Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation"

    Article Title: Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation

    Journal: Oncotarget

    doi: 10.18632/oncotarget.7159

    Blocking Src's metabolic effect sensitizes cancer cells to pro-oxidant chemotherapy A, B. Src inhibitors and chemodrug Doxorubicin (Dox) show additive/synergistic effects on ROS induction and suppression of cell growth/viability. 4T1 cells were treated with Dox (1 μg/ml) and Src inhibitors SA and SU (1 μM each). ROS levels (A) and cell growth and viability (B) were subsequently determined. C, D. Expression of PDHA1 Y289F sensitizes cells to pro-oxidant. 4T1 cells transduced with WT or Y289F PDHA1 were treated with vehicle (DMSO) or Dox, followed by measurement of ROS levels (C) and cell growth and survival (D). Error bars represent S.D. *p
    Figure Legend Snippet: Blocking Src's metabolic effect sensitizes cancer cells to pro-oxidant chemotherapy A, B. Src inhibitors and chemodrug Doxorubicin (Dox) show additive/synergistic effects on ROS induction and suppression of cell growth/viability. 4T1 cells were treated with Dox (1 μg/ml) and Src inhibitors SA and SU (1 μM each). ROS levels (A) and cell growth and viability (B) were subsequently determined. C, D. Expression of PDHA1 Y289F sensitizes cells to pro-oxidant. 4T1 cells transduced with WT or Y289F PDHA1 were treated with vehicle (DMSO) or Dox, followed by measurement of ROS levels (C) and cell growth and survival (D). Error bars represent S.D. *p

    Techniques Used: Blocking Assay, Expressing, Transduction

    Related Articles

    Modification:

    Article Title: Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
    Article Snippet: Cell culture, chemicals, antibodies and constructs HEK293, SW480, SW620 and 4T1 cells were grown in Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% bovine calf serum. .. Src inhibitors PP2, SU6656 and Saracatinib were purchased from Cayman Chemical, and chemodrug Doxorubicin from Sigma.

    Mutagenesis:

    Article Title: Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
    Article Snippet: Src inhibitors PP2, SU6656 and Saracatinib were purchased from Cayman Chemical, and chemodrug Doxorubicin from Sigma. .. PDHA1 AAA mutant was created by substituting three serine residues (S293, S300, and S232) with alanine.

    Cell Culture:

    Article Title: Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
    Article Snippet: Paragraph title: Cell culture, chemicals, antibodies and constructs ... Src inhibitors PP2, SU6656 and Saracatinib were purchased from Cayman Chemical, and chemodrug Doxorubicin from Sigma.

    Construct:

    Article Title: Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
    Article Snippet: Paragraph title: Cell culture, chemicals, antibodies and constructs ... Src inhibitors PP2, SU6656 and Saracatinib were purchased from Cayman Chemical, and chemodrug Doxorubicin from Sigma.