Journal: Food frontiers
Article Title: Black raspberries suppress pancreatic cancer through modulation of NKp46 + , CD8 + , and CD11b + immune cells
doi: 10.1002/fft2.1
Figure Lengend Snippet: (a) Immunoblots of p-c-Raf, p-MEK, p-ERK, p-STAT3, cyclin D3, and CDK4. Quantified results showed a significant decrease in the protein expression of p-c-Raf, p-MEK, p-ERK, p-STAT3, cyclin D3, and CDK4 in the pancreatic tumors from the BRB-treated mice (n=5) in comparison with the control mice (n=5). (b) Immunoblots of p-BAD, Bcl-2, full-length caspase-3, and cleaved caspase-3. Quantified results showed no significant changes in the protein expression of p-BAD, Bcl-2, or cleaved caspase-3. Control: n=5; BRBs: n=4. * p <0.05; n.s.: not significant.
Article Snippet: Antibodies for phospho-c-Raf (p-c-Raf, #9421P), phospho-mitogen activated protein kinase kinase (MEK1/2) (p-MEK, #9154), phospho-p42/44 (p-ERK, #4370), phospho-signal transducer and activator of transcription 3 (STAT3) (p-STAT3, #9145), cyclin D3 (#2936), cyclin-dependent kinase 4 (CDK4) (#2906), caspase-3 (#9662), cleaved caspase-3 (#9661), phospho-B-cell lymphoma 2 (Bcl-2)-associated death promoter (BAD) (p-BAD, #5284P), and Bcl-2 (#2870P) were purchased from Cell Signaling Technology (Danvers, MA) and used to identify their respective proteins.
Techniques: Western Blot, Expressing