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Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.
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Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.
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Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.
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Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.
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Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.

Journal: Neural Regeneration Research

Article Title: Subretinal fibrosis secondary to neovascular age-related macular degeneration: mechanisms and potential therapeutic targets

doi: 10.4103/NRR.NRR-D-23-01642

Figure Lengend Snippet: Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.

Article Snippet: Two intravitreal complement inhibitors have been approved by the Food and Drug Administration (FDA) to slow the progression of GA (Shughoury et al., 2023): pegcetacoplan (SYFOVRE, Apellis Pharmaceuticals) (Patel et al., 2023) targeting complement component 3 (C3) and avacincaptad pegol (IZERVAY, Astellas Pharmaceuticals) (Kang, 2023) targeting C5.

Techniques: Injection, Saline

Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.

Journal: Neural Regeneration Research

Article Title: Subretinal fibrosis secondary to neovascular age-related macular degeneration: mechanisms and potential therapeutic targets

doi: 10.4103/NRR.NRR-D-23-01642

Figure Lengend Snippet: Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.

Article Snippet: Two intravitreal complement inhibitors have been approved by the Food and Drug Administration (FDA) to slow the progression of GA (Shughoury et al., 2023): pegcetacoplan (SYFOVRE, Apellis Pharmaceuticals) (Patel et al., 2023) targeting complement component 3 (C3) and avacincaptad pegol (IZERVAY, Astellas Pharmaceuticals) (Kang, 2023) targeting C5.

Techniques: Injection, Saline