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A. MIC of Recombinant peptide P-113 against Candida strains (Candida albicans ATCC® 321182; Candida albicans ATCC® MYA 2876; Candida glabrata ATCC® MYA 275; Candida tropicalis ATCC® 750); MIC of Synthetic peptide P-113 against Candida albicans ATCC® 321182. Cells marked with “-” indicate microbial growth at the tested concentrations, suggesting that higher concentrations should be evaluated. B. Both peptides exhibited a concentration-dependent antifungal effect, with increasing doses leading to reduced cell viability. The toxic dose range was identified based on the significant decrease in fungal growth, highlighting comparable antifungal activity between recombinant and synthetic peptides.
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A. MIC of Recombinant peptide P-113 against Candida strains (Candida albicans ATCC® 321182; Candida albicans ATCC® MYA 2876; Candida glabrata ATCC® MYA 275; Candida tropicalis ATCC® 750); MIC of Synthetic peptide P-113 against Candida albicans ATCC® 321182. Cells marked with “-” indicate microbial growth at the tested concentrations, suggesting that higher concentrations should be evaluated. B. Both peptides exhibited a concentration-dependent antifungal effect, with increasing doses leading to reduced cell viability. The toxic dose range was identified based on the significant decrease in fungal growth, highlighting comparable antifungal activity between recombinant and synthetic peptides.
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A. MIC of Recombinant peptide P-113 against Candida strains (Candida albicans ATCC® 321182; Candida albicans ATCC® MYA 2876; Candida glabrata ATCC® MYA 275; Candida tropicalis ATCC® 750); MIC of Synthetic peptide P-113 against Candida albicans ATCC® 321182. Cells marked with “-” indicate microbial growth at the tested concentrations, suggesting that higher concentrations should be evaluated. B. Both peptides exhibited a concentration-dependent antifungal effect, with increasing doses leading to reduced cell viability. The toxic dose range was identified based on the significant decrease in fungal growth, highlighting comparable antifungal activity between recombinant and synthetic peptides.
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A. MIC of Recombinant peptide P-113 against Candida strains (Candida albicans ATCC® 321182; Candida albicans ATCC® MYA 2876; Candida glabrata ATCC® MYA 275; Candida tropicalis ATCC® 750); MIC of Synthetic peptide P-113 against Candida albicans ATCC® 321182. Cells marked with “-” indicate microbial growth at the tested concentrations, suggesting that higher concentrations should be evaluated. B. Both peptides exhibited a concentration-dependent antifungal effect, with increasing doses leading to reduced cell viability. The toxic dose range was identified based on the significant decrease in fungal growth, highlighting comparable antifungal activity between recombinant and synthetic peptides.
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A. MIC of Recombinant peptide P-113 against Candida strains (Candida albicans ATCC® 321182; Candida albicans ATCC® MYA 2876; Candida glabrata ATCC® MYA 275; Candida tropicalis ATCC® 750); MIC of Synthetic peptide P-113 against Candida albicans ATCC® 321182. Cells marked with “-” indicate microbial growth at the tested concentrations, suggesting that higher concentrations should be evaluated. B. Both peptides exhibited a concentration-dependent antifungal effect, with increasing doses leading to reduced cell viability. The toxic dose range was identified based on the significant decrease in fungal growth, highlighting comparable antifungal activity between recombinant and synthetic peptides.
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A. MIC of Recombinant peptide P-113 against Candida strains (Candida albicans ATCC® 321182; Candida albicans ATCC® MYA 2876; Candida glabrata ATCC® MYA 275; Candida tropicalis ATCC® 750); MIC of Synthetic peptide P-113 against Candida albicans ATCC® 321182. Cells marked with “-” indicate microbial growth at the tested concentrations, suggesting that higher concentrations should be evaluated. B. Both peptides exhibited a concentration-dependent antifungal effect, with increasing doses leading to reduced cell viability. The toxic dose range was identified based on the significant decrease in fungal growth, highlighting comparable antifungal activity between recombinant and synthetic peptides.
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A. MIC of Recombinant peptide P-113 against Candida strains (Candida albicans ATCC® 321182; Candida albicans ATCC® MYA 2876; Candida glabrata ATCC® MYA 275; Candida tropicalis ATCC® 750); MIC of Synthetic peptide P-113 against Candida albicans ATCC® 321182. Cells marked with “-” indicate microbial growth at the tested concentrations, suggesting that higher concentrations should be evaluated. B. Both peptides exhibited a concentration-dependent antifungal effect, with increasing doses leading to reduced cell viability. The toxic dose range was identified based on the significant decrease in fungal growth, highlighting comparable antifungal activity between recombinant and synthetic peptides.

Journal: bioRxiv

Article Title: Immobilized enzyme-assisted production of recombinant P113 peptide

doi: 10.64898/2026.04.11.717888

Figure Lengend Snippet: A. MIC of Recombinant peptide P-113 against Candida strains (Candida albicans ATCC® 321182; Candida albicans ATCC® MYA 2876; Candida glabrata ATCC® MYA 275; Candida tropicalis ATCC® 750); MIC of Synthetic peptide P-113 against Candida albicans ATCC® 321182. Cells marked with “-” indicate microbial growth at the tested concentrations, suggesting that higher concentrations should be evaluated. B. Both peptides exhibited a concentration-dependent antifungal effect, with increasing doses leading to reduced cell viability. The toxic dose range was identified based on the significant decrease in fungal growth, highlighting comparable antifungal activity between recombinant and synthetic peptides.

Article Snippet: The following standard ATCC (American Type Culture Collection®) reference yeast of Candida were used: C. albicans ATCC® 321182, C. albicans ATCC® MYA 2786, C. glabrata ATCC® MYA 275 and C. tropicalis ATCC® 750.

Techniques: Recombinant, Concentration Assay, Activity Assay