bovine type ii collagen iic  (Chondrex Inc)

Journal: Clinical and Experimental Immunology

Article Title: STAT6 and IL‐10 are required for the anti‐arthritic effects of Schistosoma mansoni via different mechanisms

doi: 10.1111/cei.13214

Figure Lengend Snippet: Genetic absence of signal transducer and activator of transcription 6 (STAT6) or interleukin (IL‐10) affects the development of collagen‐induced arthritis (CIA) in DBA/1 mice. Circles, triangles and rectangles represent type‐II collagen (IIC)‐immunized wild‐type (WT), STAT6 knock‐out (KO) and IL‐10 KO mice, respectively. Data are expressed as the mean ± standard deviation (s.d.) of total scores for four limbs (a) or total number of arthritic paws (thickness ≥ 2·2 mm) for each mouse (b). *P < 0.05 and **P < 0.01, respectively (Mann–Whitney U‐test). The combined results of four independent experiments are shown.

Article Snippet: The mice were infected with 80 cercariae by tail immersion in aged tap water containing the cercariae for 30 min. Three weeks later, the mice were immunized intradermally (i.d.) with 200 μg of bovine type‐II collagen (IIC) (Cosmo Bio Co. Ltd, Tokyo, Japan) emulsified with Freund’s complete adjuvant (FCA) (Difco Laboratories, Detroit, MI, USA) at the dorsal skin near the base of the tail.

Techniques: Knock-Out, Standard Deviation, MANN-WHITNEY

Journal: Clinical and Experimental Immunology

Article Title: STAT6 and IL‐10 are required for the anti‐arthritic effects of Schistosoma mansoni via different mechanisms

doi: 10.1111/cei.13214

Figure Lengend Snippet: Sm lowers serum anti‐type‐II collagen (IIC) immunoglobulin (Ig)G levels in wild‐type (WT) mice but not in signal transducer and activator of transcription 6 (STAT6) knock‐out (KO) or interleukin (IL)‐10 KO mice. (a–c) IgG, IgG1 and IgG2a, respectively. Closed and open bars represent non‐infected mice and Sm‐infected mice, respectively. Means ± standard deviation (s.d.) [of optical density (OD) 415] for each mouse are shown. *P < 0·05 and **P < 0·01, respectively (Student’s t‐test). The combined results of four independent experiments are shown.

Article Snippet: The mice were infected with 80 cercariae by tail immersion in aged tap water containing the cercariae for 30 min. Three weeks later, the mice were immunized intradermally (i.d.) with 200 μg of bovine type‐II collagen (IIC) (Cosmo Bio Co. Ltd, Tokyo, Japan) emulsified with Freund’s complete adjuvant (FCA) (Difco Laboratories, Detroit, MI, USA) at the dorsal skin near the base of the tail.

Techniques: Knock-Out, Infection, Standard Deviation