Structured Review

Amplyx Pharmaceuticals apx001a
Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
apx001a - by Bioz Stars, 2023-02
86/100 stars

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Structured Review

Amplyx Pharmaceuticals apx001a
Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
apx001a - by Bioz Stars, 2023-02
86/100 stars

Images


Structured Review

Amplyx Pharmaceuticals apx001a
Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
apx001a - by Bioz Stars, 2023-02
86/100 stars

Images


Structured Review

Amplyx Pharmaceuticals apx001a
Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
apx001a - by Bioz Stars, 2023-02
86/100 stars

Images


Structured Review

Amplyx Pharmaceuticals apx001a
In vitro activities of <t> APX001A </t> and select comparator antifungal agents, in vivo fitnesses in the animal model, and genetic mutations associated with drug resistance
Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
apx001a - by Bioz Stars, 2023-02
86/100 stars

Images

1) Product Images from "APX001 Pharmacokinetic/Pharmacodynamic Target Determination against Aspergillus fumigatus in an In Vivo Model of Invasive Pulmonary Aspergillosis"

Article Title: APX001 Pharmacokinetic/Pharmacodynamic Target Determination against Aspergillus fumigatus in an In Vivo Model of Invasive Pulmonary Aspergillosis

Journal: Antimicrobial Agents and Chemotherapy

doi: 10.1128/AAC.02372-18

In vitro activities of  APX001A  and select comparator antifungal agents, in vivo fitnesses in the animal model, and genetic mutations associated with drug resistance
Figure Legend Snippet: In vitro activities of APX001A and select comparator antifungal agents, in vivo fitnesses in the animal model, and genetic mutations associated with drug resistance

Techniques Used: In Vitro, In Vivo, Animal Model

Pharmacodynamic regression analysis of the PK/PD index free drug AUC/MEC and the in vivo effect of APX001 against six A. fumigatus strains. Each symbol represents the mean for four mice. The drug exposure data are expressed as the APX001A 24-h free drug AUC/MEC. The line drawn through the data points is the best-fit line based upon the sigmoid Emax formula (Hill equation). The horizontal dashed line represents the net stasis of the burden from the start of therapy. Points above the line represent an increase in burden, whereas those below the line represent a decrease in burden.
Figure Legend Snippet: Pharmacodynamic regression analysis of the PK/PD index free drug AUC/MEC and the in vivo effect of APX001 against six A. fumigatus strains. Each symbol represents the mean for four mice. The drug exposure data are expressed as the APX001A 24-h free drug AUC/MEC. The line drawn through the data points is the best-fit line based upon the sigmoid Emax formula (Hill equation). The horizontal dashed line represents the net stasis of the burden from the start of therapy. Points above the line represent an increase in burden, whereas those below the line represent a decrease in burden.

Techniques Used: In Vivo


Structured Review

Amplyx Pharmaceuticals apx001a
In vitro activities of <t> APX001A </t> and select comparator antifungal agents, in vivo fitnesses in the animal model, and genetic mutations associated with drug resistance
Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
apx001a - by Bioz Stars, 2023-02
86/100 stars

Images

1) Product Images from "APX001 Pharmacokinetic/Pharmacodynamic Target Determination against Aspergillus fumigatus in an In Vivo Model of Invasive Pulmonary Aspergillosis"

Article Title: APX001 Pharmacokinetic/Pharmacodynamic Target Determination against Aspergillus fumigatus in an In Vivo Model of Invasive Pulmonary Aspergillosis

Journal: Antimicrobial Agents and Chemotherapy

doi: 10.1128/AAC.02372-18

In vitro activities of  APX001A  and select comparator antifungal agents, in vivo fitnesses in the animal model, and genetic mutations associated with drug resistance
Figure Legend Snippet: In vitro activities of APX001A and select comparator antifungal agents, in vivo fitnesses in the animal model, and genetic mutations associated with drug resistance

Techniques Used: In Vitro, In Vivo, Animal Model

Pharmacodynamic regression analysis of the PK/PD index free drug AUC/MEC and the in vivo effect of APX001 against six A. fumigatus strains. Each symbol represents the mean for four mice. The drug exposure data are expressed as the APX001A 24-h free drug AUC/MEC. The line drawn through the data points is the best-fit line based upon the sigmoid Emax formula (Hill equation). The horizontal dashed line represents the net stasis of the burden from the start of therapy. Points above the line represent an increase in burden, whereas those below the line represent a decrease in burden.
Figure Legend Snippet: Pharmacodynamic regression analysis of the PK/PD index free drug AUC/MEC and the in vivo effect of APX001 against six A. fumigatus strains. Each symbol represents the mean for four mice. The drug exposure data are expressed as the APX001A 24-h free drug AUC/MEC. The line drawn through the data points is the best-fit line based upon the sigmoid Emax formula (Hill equation). The horizontal dashed line represents the net stasis of the burden from the start of therapy. Points above the line represent an increase in burden, whereas those below the line represent a decrease in burden.

Techniques Used: In Vivo


Structured Review

Amplyx Pharmaceuticals apx001a
Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
apx001a - by Bioz Stars, 2023-02
86/100 stars

Images


Structured Review

Amplyx Pharmaceuticals 239 apx001a
239 Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/239 apx001a/product/Amplyx Pharmaceuticals
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
239 apx001a - by Bioz Stars, 2023-02
86/100 stars

Images


Structured Review

Amplyx Pharmaceuticals apx001a
In vitro susceptibility profiles
Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
apx001a - by Bioz Stars, 2023-02
86/100 stars

Images

1) Product Images from "APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia"

Article Title: APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia

Journal: Antimicrobial Agents and Chemotherapy

doi: 10.1128/AAC.01715-18

In vitro susceptibility profiles
Figure Legend Snippet: In vitro susceptibility profiles

Techniques Used: In Vitro

Activity of Gwt1 inhibitors versus C. immitis and C. posadasii
Figure Legend Snippet: Activity of Gwt1 inhibitors versus C. immitis and C. posadasii

Techniques Used: Activity Assay


Structured Review

Amplyx Pharmaceuticals apx001a
Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
apx001a - by Bioz Stars, 2023-02
86/100 stars

Images

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    Amplyx Pharmaceuticals apx001a
    Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apx001a/product/Amplyx Pharmaceuticals
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    apx001a - by Bioz Stars, 2023-02
    86/100 stars
      Buy from Supplier

    86
    Amplyx Pharmaceuticals 239 apx001a
    239 Apx001a, supplied by Amplyx Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/239 apx001a/product/Amplyx Pharmaceuticals
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    239 apx001a - by Bioz Stars, 2023-02
    86/100 stars
      Buy from Supplier

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