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Charles River Laboratories pz 128 drug levels
Inhibition of PAR1-dependent platelet aggregation in baboons. A-C, Male baboons (10-12 kg) were administered 1, 3 or 6 mg/kg <t>PZ-128,</t> or 5% dextrose USP vehicle by iv infusion and blood collected into 100 μg/ml PPACK anticoagulant at 0, 1, 2, 6,
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1) Product Images from "Suppression of Arterial Thrombosis without Affecting Hemostatic Parameters with A Cell-Penetrating PAR1 Pepducin"

Article Title: Suppression of Arterial Thrombosis without Affecting Hemostatic Parameters with A Cell-Penetrating PAR1 Pepducin

Journal: Circulation

doi: 10.1161/CIRCULATIONAHA.112.091918

Inhibition of PAR1-dependent platelet aggregation in baboons. A-C, Male baboons (10-12 kg) were administered 1, 3 or 6 mg/kg PZ-128, or 5% dextrose USP vehicle by iv infusion and blood collected into 100 μg/ml PPACK anticoagulant at 0, 1, 2, 6,
Figure Legend Snippet: Inhibition of PAR1-dependent platelet aggregation in baboons. A-C, Male baboons (10-12 kg) were administered 1, 3 or 6 mg/kg PZ-128, or 5% dextrose USP vehicle by iv infusion and blood collected into 100 μg/ml PPACK anticoagulant at 0, 1, 2, 6,

Techniques Used: Inhibition

Effect of PZ-128 on Hemostatic Parameters in Primates and Blood from PCI Patients
Figure Legend Snippet: Effect of PZ-128 on Hemostatic Parameters in Primates and Blood from PCI Patients

Techniques Used:

Effects of PZ-128 on platelet aggregation and arterial thrombosis in guinea pig. PZ-128 or 5% dextrose USP vehicle was infused for 10 min into the jugular vein of male and female guinea pigs (0.55-0.65 kg). A-C, At the 15 min time point, whole blood was
Figure Legend Snippet: Effects of PZ-128 on platelet aggregation and arterial thrombosis in guinea pig. PZ-128 or 5% dextrose USP vehicle was infused for 10 min into the jugular vein of male and female guinea pigs (0.55-0.65 kg). A-C, At the 15 min time point, whole blood was

Techniques Used:

Inhibition of arterial thrombosis in baboons by PZ-128. 10-14 kg baboons were administered 3 mg/kg or 6 mg/kg PZ-128 by a 45 min iv infusion versus 5% dextrose vehicle (n=2-6). A, Net platelet accumulation was measured during the first 60 minutes of thrombus
Figure Legend Snippet: Inhibition of arterial thrombosis in baboons by PZ-128. 10-14 kg baboons were administered 3 mg/kg or 6 mg/kg PZ-128 by a 45 min iv infusion versus 5% dextrose vehicle (n=2-6). A, Net platelet accumulation was measured during the first 60 minutes of thrombus

Techniques Used: Inhibition

Structure and anti-platelet effects of the cell-penetrating PAR1 pepducin, PZ-128. A, Depiction of the mechanism of action of the cell-penetrating PZ-128 pepducin targeting the third intracellular loop (red) of PAR1. B, The NMR structure of PZ-128 was
Figure Legend Snippet: Structure and anti-platelet effects of the cell-penetrating PAR1 pepducin, PZ-128. A, Depiction of the mechanism of action of the cell-penetrating PZ-128 pepducin targeting the third intracellular loop (red) of PAR1. B, The NMR structure of PZ-128 was

Techniques Used: Nuclear Magnetic Resonance

Effect of PZ-128 on Hemostatic Parameters in Primates and Blood from PCI Patients
Figure Legend Snippet: Effect of PZ-128 on Hemostatic Parameters in Primates and Blood from PCI Patients

Techniques Used:

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Article Title: Suppression of Arterial Thrombosis without Affecting Hemostatic Parameters with A Cell-Penetrating PAR1 Pepducin
Article Snippet: PZ-128 drug levels in PPP samples were determined was using an API 4000 LC/MS/MS system (Agilux Laboratories, Worcester, MA).