apamin apa  (Alomone Labs)


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    Structured Review

    Alomone Labs apamin apa
    <t>Apamin</t> prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P
    Apamin Apa, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apamin apa/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    apamin apa - by Bioz Stars, 2022-01
    93/100 stars

    Images

    1) Product Images from "PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts"

    Article Title: PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts

    Journal: The Journal of Physiology

    doi: 10.1113/JP277618

    Apamin prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P
    Figure Legend Snippet: Apamin prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P

    Techniques Used:

    SK current in Sham rat VMs with application of ISO A , representative superimposed traces of I SK (blue), I Ca (black) and [Ca 2+ ] i transient (red) recorded in Sham VMs depolarized to −20 mV (left). I SK was obtained by application of 1 nmol L –1 APA. Pooled I – V and peak [Ca 2+ ]/ V relationships. B , representative inward current traces recorded in Sham VMs at 3, 6 and 8 min following application of 100 nmol L –1 ISO at −10 mV (HP −40 mV). Right: plot of normalized inward current amplitude vs . time after application of ISO. Mean ± SD, n = 5, N = 2. The normalized inward current after 6 min of ISO and 3 min of 100 nmol L –1 apamin is plotted in red. Mean ± SD, n = 8, N = 7, * P = 0.04 vs . ISO only, Student's t test.
    Figure Legend Snippet: SK current in Sham rat VMs with application of ISO A , representative superimposed traces of I SK (blue), I Ca (black) and [Ca 2+ ] i transient (red) recorded in Sham VMs depolarized to −20 mV (left). I SK was obtained by application of 1 nmol L –1 APA. Pooled I – V and peak [Ca 2+ ]/ V relationships. B , representative inward current traces recorded in Sham VMs at 3, 6 and 8 min following application of 100 nmol L –1 ISO at −10 mV (HP −40 mV). Right: plot of normalized inward current amplitude vs . time after application of ISO. Mean ± SD, n = 5, N = 2. The normalized inward current after 6 min of ISO and 3 min of 100 nmol L –1 apamin is plotted in red. Mean ± SD, n = 8, N = 7, * P = 0.04 vs . ISO only, Student's t test.

    Techniques Used:

    2) Product Images from "The Effectiveness in Activating M-Type K+ Current Produced by Solifenacin ([(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate): Independent of Its Antimuscarinic Action"

    Article Title: The Effectiveness in Activating M-Type K+ Current Produced by Solifenacin ([(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate): Independent of Its Antimuscarinic Action

    Journal: International Journal of Molecular Sciences

    doi: 10.3390/ijms222212399

    Effect of SOL, SOL plus acetylcholine (ACh), SOL plus iberiotoxin (Iber), SOL plus apamin (Apa), SOL plus tolbutamide (TLB), SOL plus chlorotoxin (ChTx), SOL plus Lino, or SOL plus TRH on the amplitude of I K(M) . In these experiments, we bathed GH 3 cells in high-K + , Ca 2+ -free solution and the recording electrode was filled with K + -enriched (145 mM) solution. Current amplitude was measured at the end of the depolarizing step from −50 to −10 mV. Each bar represents the mean ± SEM ( n = 7). * Significantly different from controls ( p
    Figure Legend Snippet: Effect of SOL, SOL plus acetylcholine (ACh), SOL plus iberiotoxin (Iber), SOL plus apamin (Apa), SOL plus tolbutamide (TLB), SOL plus chlorotoxin (ChTx), SOL plus Lino, or SOL plus TRH on the amplitude of I K(M) . In these experiments, we bathed GH 3 cells in high-K + , Ca 2+ -free solution and the recording electrode was filled with K + -enriched (145 mM) solution. Current amplitude was measured at the end of the depolarizing step from −50 to −10 mV. Each bar represents the mean ± SEM ( n = 7). * Significantly different from controls ( p

    Techniques Used:

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    Alomone Labs apamin apa
    <t>Apamin</t> prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P
    Apamin Apa, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apamin apa/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    apamin apa - by Bioz Stars, 2022-01
    93/100 stars
      Buy from Supplier

    Image Search Results


    Apamin prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P

    Journal: The Journal of Physiology

    Article Title: PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts

    doi: 10.1113/JP277618

    Figure Lengend Snippet: Apamin prolongs action potentials in TAB rat VMs and TAB rat whole heart A , representative current clamp traces in TAB rat VMs under baseline (left) or ISO (100 nmol L –1 for 3 min) (right) before and after treatment with apamin (100 nmol L –1 for 3 min). Pooled mean ± SD APD 90 . n = 5–9, N = 4–7, * P = 0.04, # P = 0.03, Student's t test. B , representative APD maps before and after APA (10 nmol L –1 ) recorded under basal conditions and in the presence of β‐adrenergic agonist ISO (50 nmol L –1 ) and the corresponding APD profile. Right, Pooled data for APD 75 . * P

    Article Snippet: Apamin (APA), a selective SK1, 2 and 3 polypeptide inhibitor (IC50 < 10 nmol L–1 ; Alomone Labs) was used to identify SK currents.

    Techniques:

    SK current in Sham rat VMs with application of ISO A , representative superimposed traces of I SK (blue), I Ca (black) and [Ca 2+ ] i transient (red) recorded in Sham VMs depolarized to −20 mV (left). I SK was obtained by application of 1 nmol L –1 APA. Pooled I – V and peak [Ca 2+ ]/ V relationships. B , representative inward current traces recorded in Sham VMs at 3, 6 and 8 min following application of 100 nmol L –1 ISO at −10 mV (HP −40 mV). Right: plot of normalized inward current amplitude vs . time after application of ISO. Mean ± SD, n = 5, N = 2. The normalized inward current after 6 min of ISO and 3 min of 100 nmol L –1 apamin is plotted in red. Mean ± SD, n = 8, N = 7, * P = 0.04 vs . ISO only, Student's t test.

    Journal: The Journal of Physiology

    Article Title: PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts

    doi: 10.1113/JP277618

    Figure Lengend Snippet: SK current in Sham rat VMs with application of ISO A , representative superimposed traces of I SK (blue), I Ca (black) and [Ca 2+ ] i transient (red) recorded in Sham VMs depolarized to −20 mV (left). I SK was obtained by application of 1 nmol L –1 APA. Pooled I – V and peak [Ca 2+ ]/ V relationships. B , representative inward current traces recorded in Sham VMs at 3, 6 and 8 min following application of 100 nmol L –1 ISO at −10 mV (HP −40 mV). Right: plot of normalized inward current amplitude vs . time after application of ISO. Mean ± SD, n = 5, N = 2. The normalized inward current after 6 min of ISO and 3 min of 100 nmol L –1 apamin is plotted in red. Mean ± SD, n = 8, N = 7, * P = 0.04 vs . ISO only, Student's t test.

    Article Snippet: Apamin (APA), a selective SK1, 2 and 3 polypeptide inhibitor (IC50 < 10 nmol L–1 ; Alomone Labs) was used to identify SK currents.

    Techniques:

    Effect of SOL, SOL plus acetylcholine (ACh), SOL plus iberiotoxin (Iber), SOL plus apamin (Apa), SOL plus tolbutamide (TLB), SOL plus chlorotoxin (ChTx), SOL plus Lino, or SOL plus TRH on the amplitude of I K(M) . In these experiments, we bathed GH 3 cells in high-K + , Ca 2+ -free solution and the recording electrode was filled with K + -enriched (145 mM) solution. Current amplitude was measured at the end of the depolarizing step from −50 to −10 mV. Each bar represents the mean ± SEM ( n = 7). * Significantly different from controls ( p

    Journal: International Journal of Molecular Sciences

    Article Title: The Effectiveness in Activating M-Type K+ Current Produced by Solifenacin ([(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate): Independent of Its Antimuscarinic Action

    doi: 10.3390/ijms222212399

    Figure Lengend Snippet: Effect of SOL, SOL plus acetylcholine (ACh), SOL plus iberiotoxin (Iber), SOL plus apamin (Apa), SOL plus tolbutamide (TLB), SOL plus chlorotoxin (ChTx), SOL plus Lino, or SOL plus TRH on the amplitude of I K(M) . In these experiments, we bathed GH 3 cells in high-K + , Ca 2+ -free solution and the recording electrode was filled with K + -enriched (145 mM) solution. Current amplitude was measured at the end of the depolarizing step from −50 to −10 mV. Each bar represents the mean ± SEM ( n = 7). * Significantly different from controls ( p

    Article Snippet: Linopirdine (Lino), tetrodotoxin (TTX), thyrotropin releasing hormone (TRH) and tolbutamide (TLB) were acquired from Sigma-Aldrich (Merck, Taipei, Taiwan), and iberiotoxin (Iber) and apamin (Apa) were from Alomone (Asia Bioscience, Taipei, Taiwan).

    Techniques: