tnfα  (Kingfisher Biotech)


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  • 93
    Name:
    Recombinant Canine TNF alpha
    Description:

    Catalog Number:
    RP0261D-100
    Price:
    750.0
    Source:
    Yeast
    Purity:
    98%
    Quantity:
    100 ug
    Molecular Weight:
    17.3 kDa
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    Structured Review

    Kingfisher Biotech tnfα
    Bioactive factors associated with canine ASC and PMSC mediated immunosuppression differs. Canine adipose-derived MSCs ( ASCs ) and placenta-derived MSCs ( PMSCs ) increase production of vascular endothelial growth factor (VEGF) and IL-6. a Both canine ASCs and PMSCs mildly increased production of VEGF when co-cultured with mitogen (ConA) activated peripheral blood mononuclear cells (PBMCs). b Canine ASCs and PMSCs upregulated IL-6 production; however, PMSCs secreted higher levels of IL-6 as compared to ASCs. c Production of IL-8 by canine ASCs was comparable to basal levels of IL-8 produced by stimulated PBMCs; however, PMSCs increased levels of IL-8 greater than basal levels. Additionally, regulation of inflammatory mediators by canine ASCs and PMSCs was similar. d IL-2 production from stimulated PBMCs was mildly reduced by both canine ASCs and PMSCs. e Canine ASCs and PMSCs inhibit production of tumor necrosis factor alpha ( <t>TNFα</t> ) by stimulated PBMCs to comparable levels. Data presented as mean and standard error. ConA, concanavalin A IL, interleukin; TNFα, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor

    https://www.bioz.com/result/tnfα/product/Kingfisher Biotech
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tnfα - by Bioz Stars, 2021-09
    93/100 stars

    Images

    1) Product Images from "Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease"

    Article Title: Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease

    Journal: Stem Cell Research & Therapy

    doi: 10.1186/s13287-020-01799-0

    Bioactive factors associated with canine ASC and PMSC mediated immunosuppression differs. Canine adipose-derived MSCs ( ASCs ) and placenta-derived MSCs ( PMSCs ) increase production of vascular endothelial growth factor (VEGF) and IL-6. a Both canine ASCs and PMSCs mildly increased production of VEGF when co-cultured with mitogen (ConA) activated peripheral blood mononuclear cells (PBMCs). b Canine ASCs and PMSCs upregulated IL-6 production; however, PMSCs secreted higher levels of IL-6 as compared to ASCs. c Production of IL-8 by canine ASCs was comparable to basal levels of IL-8 produced by stimulated PBMCs; however, PMSCs increased levels of IL-8 greater than basal levels. Additionally, regulation of inflammatory mediators by canine ASCs and PMSCs was similar. d IL-2 production from stimulated PBMCs was mildly reduced by both canine ASCs and PMSCs. e Canine ASCs and PMSCs inhibit production of tumor necrosis factor alpha ( TNFα ) by stimulated PBMCs to comparable levels. Data presented as mean and standard error. ConA, concanavalin A IL, interleukin; TNFα, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor
    Figure Legend Snippet: Bioactive factors associated with canine ASC and PMSC mediated immunosuppression differs. Canine adipose-derived MSCs ( ASCs ) and placenta-derived MSCs ( PMSCs ) increase production of vascular endothelial growth factor (VEGF) and IL-6. a Both canine ASCs and PMSCs mildly increased production of VEGF when co-cultured with mitogen (ConA) activated peripheral blood mononuclear cells (PBMCs). b Canine ASCs and PMSCs upregulated IL-6 production; however, PMSCs secreted higher levels of IL-6 as compared to ASCs. c Production of IL-8 by canine ASCs was comparable to basal levels of IL-8 produced by stimulated PBMCs; however, PMSCs increased levels of IL-8 greater than basal levels. Additionally, regulation of inflammatory mediators by canine ASCs and PMSCs was similar. d IL-2 production from stimulated PBMCs was mildly reduced by both canine ASCs and PMSCs. e Canine ASCs and PMSCs inhibit production of tumor necrosis factor alpha ( TNFα ) by stimulated PBMCs to comparable levels. Data presented as mean and standard error. ConA, concanavalin A IL, interleukin; TNFα, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor

    Techniques Used: Derivative Assay, Cell Culture, Produced

    Direct stimulation of canine ASCs and PMSCs leads to production of IDO and PGE 2 . Canine adipose-derived MSCs ( ASCs ) and placenta-derived MSCs ( PMSCs ) secrete increased levels of indoleamine 2,3 dioxygenase (IDO) activity and prostaglandin E 2 (PGE 2 ) in response to direct stimulation using recombinant interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα ) . a IDO activity is directly proportional to the conversion of tryptophan to N -formyl kynurenine. ASCs and PMSCs increase IDO activity in response to dual stimulation with IFNγ and TNFα. IFNγ is the main contributor to the production of IDO. IFNγ- and TNFα-stimulated ASCs promote significantly higher levels of IDO activity as compared to PMSCs. b Canine ASCs and PMSCs produce comparable levels of prostaglandin E 2 (PGE 2 ) in response to dual stimulation with IFNγ and TNFα. TNFα is the major contributor to MSC-mediated PGE 2 production. Data presented as mean and standard error. * p
    Figure Legend Snippet: Direct stimulation of canine ASCs and PMSCs leads to production of IDO and PGE 2 . Canine adipose-derived MSCs ( ASCs ) and placenta-derived MSCs ( PMSCs ) secrete increased levels of indoleamine 2,3 dioxygenase (IDO) activity and prostaglandin E 2 (PGE 2 ) in response to direct stimulation using recombinant interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα ) . a IDO activity is directly proportional to the conversion of tryptophan to N -formyl kynurenine. ASCs and PMSCs increase IDO activity in response to dual stimulation with IFNγ and TNFα. IFNγ is the main contributor to the production of IDO. IFNγ- and TNFα-stimulated ASCs promote significantly higher levels of IDO activity as compared to PMSCs. b Canine ASCs and PMSCs produce comparable levels of prostaglandin E 2 (PGE 2 ) in response to dual stimulation with IFNγ and TNFα. TNFα is the major contributor to MSC-mediated PGE 2 production. Data presented as mean and standard error. * p

    Techniques Used: Derivative Assay, Activity Assay, Recombinant

    Related Articles

    Recombinant:

    Article Title: Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease
    Article Snippet: .. At plating, MSC was stimulated with IFNγ (50 ng/mL; canine recombinant IFNγ, Kingfisher, St. Paul, MN) or TNFα (50 ng/mL; canine recombinant TNFα, Kingfisher) or a dual stimulation with both IFNγ (50 ng/mL, Kingfisher) and TNFα (50 ng/mL, Kingfisher). ..

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  • 93
    Kingfisher Biotech tnfα
    Bioactive factors associated with canine ASC and PMSC mediated immunosuppression differs. Canine adipose-derived MSCs ( ASCs ) and placenta-derived MSCs ( PMSCs ) increase production of vascular endothelial growth factor (VEGF) and IL-6. a Both canine ASCs and PMSCs mildly increased production of VEGF when co-cultured with mitogen (ConA) activated peripheral blood mononuclear cells (PBMCs). b Canine ASCs and PMSCs upregulated IL-6 production; however, PMSCs secreted higher levels of IL-6 as compared to ASCs. c Production of IL-8 by canine ASCs was comparable to basal levels of IL-8 produced by stimulated PBMCs; however, PMSCs increased levels of IL-8 greater than basal levels. Additionally, regulation of inflammatory mediators by canine ASCs and PMSCs was similar. d IL-2 production from stimulated PBMCs was mildly reduced by both canine ASCs and PMSCs. e Canine ASCs and PMSCs inhibit production of tumor necrosis factor alpha ( <t>TNFα</t> ) by stimulated PBMCs to comparable levels. Data presented as mean and standard error. ConA, concanavalin A IL, interleukin; TNFα, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor
    Tnfα, supplied by Kingfisher Biotech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tnfα/product/Kingfisher Biotech
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    tnfα - by Bioz Stars, 2021-09
    93/100 stars
      Buy from Supplier

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    Bioactive factors associated with canine ASC and PMSC mediated immunosuppression differs. Canine adipose-derived MSCs ( ASCs ) and placenta-derived MSCs ( PMSCs ) increase production of vascular endothelial growth factor (VEGF) and IL-6. a Both canine ASCs and PMSCs mildly increased production of VEGF when co-cultured with mitogen (ConA) activated peripheral blood mononuclear cells (PBMCs). b Canine ASCs and PMSCs upregulated IL-6 production; however, PMSCs secreted higher levels of IL-6 as compared to ASCs. c Production of IL-8 by canine ASCs was comparable to basal levels of IL-8 produced by stimulated PBMCs; however, PMSCs increased levels of IL-8 greater than basal levels. Additionally, regulation of inflammatory mediators by canine ASCs and PMSCs was similar. d IL-2 production from stimulated PBMCs was mildly reduced by both canine ASCs and PMSCs. e Canine ASCs and PMSCs inhibit production of tumor necrosis factor alpha ( TNFα ) by stimulated PBMCs to comparable levels. Data presented as mean and standard error. ConA, concanavalin A IL, interleukin; TNFα, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor

    Journal: Stem Cell Research & Therapy

    Article Title: Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease

    doi: 10.1186/s13287-020-01799-0

    Figure Lengend Snippet: Bioactive factors associated with canine ASC and PMSC mediated immunosuppression differs. Canine adipose-derived MSCs ( ASCs ) and placenta-derived MSCs ( PMSCs ) increase production of vascular endothelial growth factor (VEGF) and IL-6. a Both canine ASCs and PMSCs mildly increased production of VEGF when co-cultured with mitogen (ConA) activated peripheral blood mononuclear cells (PBMCs). b Canine ASCs and PMSCs upregulated IL-6 production; however, PMSCs secreted higher levels of IL-6 as compared to ASCs. c Production of IL-8 by canine ASCs was comparable to basal levels of IL-8 produced by stimulated PBMCs; however, PMSCs increased levels of IL-8 greater than basal levels. Additionally, regulation of inflammatory mediators by canine ASCs and PMSCs was similar. d IL-2 production from stimulated PBMCs was mildly reduced by both canine ASCs and PMSCs. e Canine ASCs and PMSCs inhibit production of tumor necrosis factor alpha ( TNFα ) by stimulated PBMCs to comparable levels. Data presented as mean and standard error. ConA, concanavalin A IL, interleukin; TNFα, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor

    Article Snippet: At plating, MSC was stimulated with IFNγ (50 ng/mL; canine recombinant IFNγ, Kingfisher, St. Paul, MN) or TNFα (50 ng/mL; canine recombinant TNFα, Kingfisher) or a dual stimulation with both IFNγ (50 ng/mL, Kingfisher) and TNFα (50 ng/mL, Kingfisher).

    Techniques: Derivative Assay, Cell Culture, Produced

    Direct stimulation of canine ASCs and PMSCs leads to production of IDO and PGE 2 . Canine adipose-derived MSCs ( ASCs ) and placenta-derived MSCs ( PMSCs ) secrete increased levels of indoleamine 2,3 dioxygenase (IDO) activity and prostaglandin E 2 (PGE 2 ) in response to direct stimulation using recombinant interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα ) . a IDO activity is directly proportional to the conversion of tryptophan to N -formyl kynurenine. ASCs and PMSCs increase IDO activity in response to dual stimulation with IFNγ and TNFα. IFNγ is the main contributor to the production of IDO. IFNγ- and TNFα-stimulated ASCs promote significantly higher levels of IDO activity as compared to PMSCs. b Canine ASCs and PMSCs produce comparable levels of prostaglandin E 2 (PGE 2 ) in response to dual stimulation with IFNγ and TNFα. TNFα is the major contributor to MSC-mediated PGE 2 production. Data presented as mean and standard error. * p

    Journal: Stem Cell Research & Therapy

    Article Title: Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease

    doi: 10.1186/s13287-020-01799-0

    Figure Lengend Snippet: Direct stimulation of canine ASCs and PMSCs leads to production of IDO and PGE 2 . Canine adipose-derived MSCs ( ASCs ) and placenta-derived MSCs ( PMSCs ) secrete increased levels of indoleamine 2,3 dioxygenase (IDO) activity and prostaglandin E 2 (PGE 2 ) in response to direct stimulation using recombinant interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα ) . a IDO activity is directly proportional to the conversion of tryptophan to N -formyl kynurenine. ASCs and PMSCs increase IDO activity in response to dual stimulation with IFNγ and TNFα. IFNγ is the main contributor to the production of IDO. IFNγ- and TNFα-stimulated ASCs promote significantly higher levels of IDO activity as compared to PMSCs. b Canine ASCs and PMSCs produce comparable levels of prostaglandin E 2 (PGE 2 ) in response to dual stimulation with IFNγ and TNFα. TNFα is the major contributor to MSC-mediated PGE 2 production. Data presented as mean and standard error. * p

    Article Snippet: At plating, MSC was stimulated with IFNγ (50 ng/mL; canine recombinant IFNγ, Kingfisher, St. Paul, MN) or TNFα (50 ng/mL; canine recombinant TNFα, Kingfisher) or a dual stimulation with both IFNγ (50 ng/mL, Kingfisher) and TNFα (50 ng/mL, Kingfisher).

    Techniques: Derivative Assay, Activity Assay, Recombinant