junctional adhesion molecule 1 (Sino Biological)
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Name:
JAM A Junctional Adhesion Molecule A cDNA ORF Clone Human C GFPSpark tag
Description:
Full length Clone DNA of Human F11 receptor F11R with C terminal GFPSpark tag
Catalog Number:
hg10198-acg
Product Aliases:
CD321 cDNA ORF Clone Human, JAM cDNA ORF Clone Human, JAM1 cDNA ORF Clone Human, JAMA cDNA ORF Clone Human, JCAM cDNA ORF Clone Human, KAT cDNA ORF Clone Human, PAM-1 cDNA ORF Clone Human
Price:
225.0
Applications:
Stable or Transient mammalian expression
Size:
1Unit
Category:
cDNA Clone
Molecule Name:
F11R,Ly106,JAM-A ,Junctional Adhesion Molecule A
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Structured Review
Sino Biological
junctional adhesion molecule 1
Full length Clone DNA of Human F11 receptor F11R with C terminal GFPSpark tag
https://www.bioz.com/result/junctional adhesion molecule 1/product/Sino Biological
Average 91 stars, based on 4 article reviews
Price from $9.99 to $1999.99
Full length Clone DNA of Human F11 receptor F11R with C terminal GFPSpark tag
https://www.bioz.com/result/junctional adhesion molecule 1/product/Sino Biological
Average 91 stars, based on 4 article reviews
Price from $9.99 to $1999.99
junctional adhesion molecule 1 - by Bioz Stars,
2021-02
91/100 stars
Related Products / Commonly Used Together
Images
1) Product Images from "Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA"
Article Title: Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA
Journal: Arthritis Research & Therapy
doi: 10.1186/s13075-018-1710-0
Figure Legend Snippet: Effect of PECAM-1 on degranulation in CD177-negative neutrophils. a SHP-1 phosphorylation was detected in neutrophils incubated with platelet endothelial cell adhesion molecule-1 (PECAM-1). b Effect of PECAM-1 on degranulation of CD177-negative and mixed neutrophils. Degranulation induced by proteinase-3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-positive immunoglobulin (Ig)Gs (PR3 ANCA) was little influenced by preincubation with soluble PECAM-1 in CD177-negative neutrophils, but it was significantly inhibited by soluble PECAM-1 in mixed neutrophils. The level of lactoferrin was expressed as a percentage of control in each subset. The purity of the CD177-positive subset in mixed neutrophils was 72.7 ± 10.7% and the purity of CD177-negative neutrophils after selecting was 86.4 ± 8.5%. Bars represent mean ± SD of repeated measurements from four independent experiments. ** p
Techniques Used: Incubation
Figure Legend Snippet: Downregulation of mPR3 after treating neutrophils with PECAM-1. a interaction between platelet endothelial cell adhesion molecule-1 (PECAM-1) and CD177 at various concentrations. b Representative histogram of the effect of PECAM-1 on membrane-bound proteinase-3 (mPR3) expression in a dose-dependent manner. c Incubation of TNF-α-primed neutrophils with PECAM-1 at 30 μg/ml significantly decreased mPR3 expression. Bars denote means ± SD of mPR3 expression (mean fluorescence intensity; MFI). d Incubation of TNF-α-primed neutrophils with PECAM-1 at 30 μg/ml significantly increased proteinase-3 (PR3) levels in the supernatant. Bars denote means ± SD of PR3 concentration (ng/ml). Neutrophils treated with phorbol myristate acetate (PMA) were employed as positive control. * p
Techniques Used: Expressing, Incubation, Fluorescence, Concentration Assay, Positive Control
Figure Legend Snippet: Platelet endothelial cell adhesion molecule-1 (PECAM-1) interaction with CD177 decreased GEnC activation and injury induced by patient-derived proteinase-3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-positive immunoglobulin (Ig)Gs (PR3 ANCA). By preincubation with PECAM-1, the levels of soluble intercellular cell adhesion molecule-1 (sICAM-1) significantly decreased in the supernatants of GEnCs treated with neutrophil plus patient-derived PR3-ANCA-positive IgGs. Bars denote means ± SD of sICAM-1 concentration (pg/mL). * p
Techniques Used: Activation Assay, Derivative Assay, Concentration Assay
2) Product Images from "Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA"
Article Title: Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA
Journal: Arthritis Research & Therapy
doi: 10.1186/s13075-018-1710-0
Figure Legend Snippet: Effect of PECAM-1 on degranulation in CD177-negative neutrophils. a SHP-1 phosphorylation was detected in neutrophils incubated with platelet endothelial cell adhesion molecule-1 (PECAM-1). b Effect of PECAM-1 on degranulation of CD177-negative and mixed neutrophils. Degranulation induced by proteinase-3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-positive immunoglobulin (Ig)Gs (PR3 ANCA) was little influenced by preincubation with soluble PECAM-1 in CD177-negative neutrophils, but it was significantly inhibited by soluble PECAM-1 in mixed neutrophils. The level of lactoferrin was expressed as a percentage of control in each subset. The purity of the CD177-positive subset in mixed neutrophils was 72.7 ± 10.7% and the purity of CD177-negative neutrophils after selecting was 86.4 ± 8.5%. Bars represent mean ± SD of repeated measurements from four independent experiments. ** p
Techniques Used: Incubation
Figure Legend Snippet: Downregulation of mPR3 after treating neutrophils with PECAM-1. a interaction between platelet endothelial cell adhesion molecule-1 (PECAM-1) and CD177 at various concentrations. b Representative histogram of the effect of PECAM-1 on membrane-bound proteinase-3 (mPR3) expression in a dose-dependent manner. c Incubation of TNF-α-primed neutrophils with PECAM-1 at 30 μg/ml significantly decreased mPR3 expression. Bars denote means ± SD of mPR3 expression (mean fluorescence intensity; MFI). d Incubation of TNF-α-primed neutrophils with PECAM-1 at 30 μg/ml significantly increased proteinase-3 (PR3) levels in the supernatant. Bars denote means ± SD of PR3 concentration (ng/ml). Neutrophils treated with phorbol myristate acetate (PMA) were employed as positive control. * p
Techniques Used: Expressing, Incubation, Fluorescence, Concentration Assay, Positive Control
Figure Legend Snippet: Platelet endothelial cell adhesion molecule-1 (PECAM-1) interaction with CD177 decreased GEnC activation and injury induced by patient-derived proteinase-3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-positive immunoglobulin (Ig)Gs (PR3 ANCA). By preincubation with PECAM-1, the levels of soluble intercellular cell adhesion molecule-1 (sICAM-1) significantly decreased in the supernatants of GEnCs treated with neutrophil plus patient-derived PR3-ANCA-positive IgGs. Bars denote means ± SD of sICAM-1 concentration (pg/mL). * p
Techniques Used: Activation Assay, Derivative Assay, Concentration Assay
3) Product Images from "Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA"
Article Title: Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA
Journal: Arthritis Research & Therapy
doi: 10.1186/s13075-018-1710-0
Figure Legend Snippet: Effect of PECAM-1 on degranulation in CD177-negative neutrophils. a SHP-1 phosphorylation was detected in neutrophils incubated with platelet endothelial cell adhesion molecule-1 (PECAM-1). b Effect of PECAM-1 on degranulation of CD177-negative and mixed neutrophils. Degranulation induced by proteinase-3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-positive immunoglobulin (Ig)Gs (PR3 ANCA) was little influenced by preincubation with soluble PECAM-1 in CD177-negative neutrophils, but it was significantly inhibited by soluble PECAM-1 in mixed neutrophils. The level of lactoferrin was expressed as a percentage of control in each subset. The purity of the CD177-positive subset in mixed neutrophils was 72.7 ± 10.7% and the purity of CD177-negative neutrophils after selecting was 86.4 ± 8.5%. Bars represent mean ± SD of repeated measurements from four independent experiments. ** p
Techniques Used: Incubation
Figure Legend Snippet: Downregulation of mPR3 after treating neutrophils with PECAM-1. a interaction between platelet endothelial cell adhesion molecule-1 (PECAM-1) and CD177 at various concentrations. b Representative histogram of the effect of PECAM-1 on membrane-bound proteinase-3 (mPR3) expression in a dose-dependent manner. c Incubation of TNF-α-primed neutrophils with PECAM-1 at 30 μg/ml significantly decreased mPR3 expression. Bars denote means ± SD of mPR3 expression (mean fluorescence intensity; MFI). d Incubation of TNF-α-primed neutrophils with PECAM-1 at 30 μg/ml significantly increased proteinase-3 (PR3) levels in the supernatant. Bars denote means ± SD of PR3 concentration (ng/ml). Neutrophils treated with phorbol myristate acetate (PMA) were employed as positive control. * p
Techniques Used: Expressing, Incubation, Fluorescence, Concentration Assay, Positive Control
Figure Legend Snippet: Platelet endothelial cell adhesion molecule-1 (PECAM-1) interaction with CD177 decreased GEnC activation and injury induced by patient-derived proteinase-3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-positive immunoglobulin (Ig)Gs (PR3 ANCA). By preincubation with PECAM-1, the levels of soluble intercellular cell adhesion molecule-1 (sICAM-1) significantly decreased in the supernatants of GEnCs treated with neutrophil plus patient-derived PR3-ANCA-positive IgGs. Bars denote means ± SD of sICAM-1 concentration (pg/mL). * p
Techniques Used: Activation Assay, Derivative Assay, Concentration Assay
Related Articles
Recombinant:Article Title: Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA Article Snippet: .. Recombinant PECAM-1, |