probdnf  (Alomone Labs)


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    Alomone Labs probdnf
    Probdnf, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/probdnf/product/Alomone Labs
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    probdnf - by Bioz Stars, 2022-05
    90/100 stars

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    • guinea pig anti probdnf antibody  (Alomone Labs)
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    Alomone Labs guinea pig anti probdnf antibody
    proBNDF-mediated p75NTR activation in cortical PV cells reduces their perisomatic boutons and restores ocular dominance plasticity in adult visual cortex in vivo . (a) Experimental approach. (b) The number of immunolabeled PV-positive puncta (green) surrounding NeuN-positive neuronal somata (red) is reduced in the binocular visual cortex ipsilateral to the minipump releasing <t>mut-proBDNF</t> (Ipsi) compared to the contralateral cortex (Contra) in the same animal. On the other hand, the number of PV-positive puncta per NeuN-positive profile in the ipsilateral cortex of PV-CRE; p75 flx/flx mice is similar to that observed in the contralateral, untreated cortex. (c) Low (c1) and high (c2) magnification of PNN (red, WFA staining) enwrapping PV cells (green) show a dramatic reduction in both PNN density and intensity in the visual cortex infused with mut-proBFNF. This effects is abolished in PV-CRE; p75 flx/flx mice. Scale bar, c1: 100µm; b, c2: 10µm. (d) Quantification of the mean number of PV-positive puncta per NeuN-positive profile in ipsilateral compared to contralateral cortex. Ipsi/Contra ratio is obtained for each animal, and then averaged between different animals. Mean Ipsi/Contra ratio is significantly reduced in Mut-proBDNF infused p75 Ctrl but not in PV-CRE; p75 flx/flx mice (t-test, p
    Guinea Pig Anti Probdnf Antibody, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/guinea pig anti probdnf antibody/product/Alomone Labs
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    guinea pig anti probdnf antibody - by Bioz Stars, 2022-05
    90/100 stars
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    proBNDF-mediated p75NTR activation in cortical PV cells reduces their perisomatic boutons and restores ocular dominance plasticity in adult visual cortex in vivo . (a) Experimental approach. (b) The number of immunolabeled PV-positive puncta (green) surrounding NeuN-positive neuronal somata (red) is reduced in the binocular visual cortex ipsilateral to the minipump releasing mut-proBDNF (Ipsi) compared to the contralateral cortex (Contra) in the same animal. On the other hand, the number of PV-positive puncta per NeuN-positive profile in the ipsilateral cortex of PV-CRE; p75 flx/flx mice is similar to that observed in the contralateral, untreated cortex. (c) Low (c1) and high (c2) magnification of PNN (red, WFA staining) enwrapping PV cells (green) show a dramatic reduction in both PNN density and intensity in the visual cortex infused with mut-proBFNF. This effects is abolished in PV-CRE; p75 flx/flx mice. Scale bar, c1: 100µm; b, c2: 10µm. (d) Quantification of the mean number of PV-positive puncta per NeuN-positive profile in ipsilateral compared to contralateral cortex. Ipsi/Contra ratio is obtained for each animal, and then averaged between different animals. Mean Ipsi/Contra ratio is significantly reduced in Mut-proBDNF infused p75 Ctrl but not in PV-CRE; p75 flx/flx mice (t-test, p

    Journal: bioRxiv

    Article Title: p75 Neurotrophin Receptor Regulates the Timing of the Maturation of Cortical Parvalbumin Cell Connectivity and Promotes Ocular Dominance Plasticity in Adult Visual Cortex

    doi: 10.1101/392159

    Figure Lengend Snippet: proBNDF-mediated p75NTR activation in cortical PV cells reduces their perisomatic boutons and restores ocular dominance plasticity in adult visual cortex in vivo . (a) Experimental approach. (b) The number of immunolabeled PV-positive puncta (green) surrounding NeuN-positive neuronal somata (red) is reduced in the binocular visual cortex ipsilateral to the minipump releasing mut-proBDNF (Ipsi) compared to the contralateral cortex (Contra) in the same animal. On the other hand, the number of PV-positive puncta per NeuN-positive profile in the ipsilateral cortex of PV-CRE; p75 flx/flx mice is similar to that observed in the contralateral, untreated cortex. (c) Low (c1) and high (c2) magnification of PNN (red, WFA staining) enwrapping PV cells (green) show a dramatic reduction in both PNN density and intensity in the visual cortex infused with mut-proBFNF. This effects is abolished in PV-CRE; p75 flx/flx mice. Scale bar, c1: 100µm; b, c2: 10µm. (d) Quantification of the mean number of PV-positive puncta per NeuN-positive profile in ipsilateral compared to contralateral cortex. Ipsi/Contra ratio is obtained for each animal, and then averaged between different animals. Mean Ipsi/Contra ratio is significantly reduced in Mut-proBDNF infused p75 Ctrl but not in PV-CRE; p75 flx/flx mice (t-test, p

    Article Snippet: In addition, we tested the following anti-proBDNF antibodies: chicken anti-proBDNF (Millipore, AB9042), rabbit-anti-proBDNF (Alomone Labs, ANT-006) and guinea-pig-anti-proBDNF (Alomone Lab, AGP-032).

    Techniques: Activation Assay, In Vivo, Immunolabeling, Mouse Assay, Staining, T-Test

    mut-proBDNF can destabilize PV cell innervation even after it has reached maturity. (a) Control PV cell (a1, Ctrl, green) at EP32 with exuberant innervation field characterized by extensive branching contacting the majority of potential targets, dense boutons along axons (a2), and terminal branches with prominent and clustered boutons (a3; arrowheads) around pyramidal cell somata (NeuN immunostaining, blue). (b) PV cell treated with wt-proBDNF from EP26-32 shows overall similar axon size (b1), percentage of potentially targeted neurons (B2) and perisomatic innervations (b3) as control, untreated PV cells. (c) PV cell treated with mut-proBDNF from EP26-32 shows a drastic reduction both in percentage of innervated cells (c2) and perisomatic innervation (c3). Stars indicate pyramidal cells somata that are not innervated. Scale bar, a1-c1: 50µm; a2-c2: 10µm; a3-c3: 5µm. (d) Perisomatic bouton density (e) terminal branching and (f) percentage of innervated cells of the three experimental groups. One-way Anova, post hoc Tukey test, p

    Journal: bioRxiv

    Article Title: p75 Neurotrophin Receptor Regulates the Timing of the Maturation of Cortical Parvalbumin Cell Connectivity and Promotes Ocular Dominance Plasticity in Adult Visual Cortex

    doi: 10.1101/392159

    Figure Lengend Snippet: mut-proBDNF can destabilize PV cell innervation even after it has reached maturity. (a) Control PV cell (a1, Ctrl, green) at EP32 with exuberant innervation field characterized by extensive branching contacting the majority of potential targets, dense boutons along axons (a2), and terminal branches with prominent and clustered boutons (a3; arrowheads) around pyramidal cell somata (NeuN immunostaining, blue). (b) PV cell treated with wt-proBDNF from EP26-32 shows overall similar axon size (b1), percentage of potentially targeted neurons (B2) and perisomatic innervations (b3) as control, untreated PV cells. (c) PV cell treated with mut-proBDNF from EP26-32 shows a drastic reduction both in percentage of innervated cells (c2) and perisomatic innervation (c3). Stars indicate pyramidal cells somata that are not innervated. Scale bar, a1-c1: 50µm; a2-c2: 10µm; a3-c3: 5µm. (d) Perisomatic bouton density (e) terminal branching and (f) percentage of innervated cells of the three experimental groups. One-way Anova, post hoc Tukey test, p

    Article Snippet: In addition, we tested the following anti-proBDNF antibodies: chicken anti-proBDNF (Millipore, AB9042), rabbit-anti-proBDNF (Alomone Labs, ANT-006) and guinea-pig-anti-proBDNF (Alomone Lab, AGP-032).

    Techniques: Immunostaining