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Biological activities of JNNs 1–6 against JAK1, JAK2 and  JAK3.

Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

Article Title: Discovery and biological evaluation of a novel and highly potent JAK2 inhibitor for the treatment of triple negative breast cancer

doi: 10.1080/14756366.2025.2488127

Figure Lengend Snippet: Biological activities of JNNs 1–6 against JAK1, JAK2 and JAK3.

Article Snippet: The inhibitory effects of the hit compounds on the JAK1, JAK2, and JAK3 kinases were assessed using the ADP-Glo kinase kit provided by BPS Bioscience (San Diego, CA, USA).

Techniques:

Inhibitory effects of 3b on the activity of protein kinases and HDAC1.

Journal: Scientific Reports

Article Title: In Silico and in vitro evaluation of the anticancer effect of a 1,5-Benzodiazepin-2-One derivative (3b) revealing potent dual inhibition of HER2 and HDAC1

doi: 10.1038/s41598-025-97786-7

Figure Lengend Snippet: Inhibitory effects of 3b on the activity of protein kinases and HDAC1.

Article Snippet: Aurora kinase C assay kit (catalog No. 82096), CDK2 (catalog No. 79599), CDK5 (catalog No. 79600), EGFR assay kit (catalog No. 40321), HDAC1 assay kit (catalog No. 50061), HER2 assay kit (catalog No. 40721), JAK1 assay kit (catalog No. 79518), JAK2 assay kit (catalog No. 79520) and JAK3 assay kit (catalog No. 79521) were purchased from BPS Bioscience (San Diego, CA, US). mTOR activity kit (catalog No. CBA055) was purchased from Calbiochem ® (San Diego, CA, US).

Techniques: Activity Assay