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Image Search Results


A , A total of 17 cell clusters and 8 cell types based on UMAP visualization. B through C , Expression patterns of 4 genes ( TAGLN2 , SWAP70 , DHX58 , and APOB ) across cell‐type clusters visualized using UMAP and dot plots. D , Differential expression of 3 genes ( TAGLN2 , SWAP70 , and DHX58 ) between atherosclerotic plaques and controls, shown in 8 cell types at average Log2FC >0.25 and FDR <0.05 level. FDR indicates false discovery rate; Log2FC, log2 fold change; SMC, smooth muscle cells; T/NK, T or Natural Killer cells and UMAP, uniform manifold approximation and projection.

Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Article Title: Multi‐Omic Insight Into the Molecular Networks in the Pathogenesis of Coronary Artery Disease

doi: 10.1161/JAHA.124.037203

Figure Lengend Snippet: A , A total of 17 cell clusters and 8 cell types based on UMAP visualization. B through C , Expression patterns of 4 genes ( TAGLN2 , SWAP70 , DHX58 , and APOB ) across cell‐type clusters visualized using UMAP and dot plots. D , Differential expression of 3 genes ( TAGLN2 , SWAP70 , and DHX58 ) between atherosclerotic plaques and controls, shown in 8 cell types at average Log2FC >0.25 and FDR <0.05 level. FDR indicates false discovery rate; Log2FC, log2 fold change; SMC, smooth muscle cells; T/NK, T or Natural Killer cells and UMAP, uniform manifold approximation and projection.

Article Snippet: Membranes were incubated with the following primary antibodies: DHX58 (1:500, Proteintech, 10 494‐1‐AP), SWAP70 (1:1000, Abclonal, A14857), TAGLN2 (1:2000, Proteintech, 10 234‐2‐AP), and GAPDH (1:20000, Proteintech, 10 494‐1‐AP), which served as the loading control.

Techniques: Expressing, Quantitative Proteomics

A , Sequential panels show Oil Red O staining of the aorta, Oil Red O staining of the aortic valve, hematoxylin and eosin staining of the aortic valve, and Masson's trichrome staining of the aortic valve. B , Western blot DHX58, SWAP70, and TAGLN2 protein expression in the aortic tissues of AS and control mice, with GAPDH used as a loading control. C , Quantification of DHX58, SWAP70, and TAGLN2 protein levels in the aortic tissues of AS and control mice. Data are presented as mean±SE (n=6 per group, analyzed using the Mann‐Whitney U test). D , Quantification of DHX58, SWAP70 , and TAGLN2 mRNA levels in the aortic tissues of AS and control mice. Data are presented as mean±SE (n=6 per group, analyzed using the Mann‐Whitney U test). AS indicates atherosclerotic. KD, kiloDalton.

Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Article Title: Multi‐Omic Insight Into the Molecular Networks in the Pathogenesis of Coronary Artery Disease

doi: 10.1161/JAHA.124.037203

Figure Lengend Snippet: A , Sequential panels show Oil Red O staining of the aorta, Oil Red O staining of the aortic valve, hematoxylin and eosin staining of the aortic valve, and Masson's trichrome staining of the aortic valve. B , Western blot DHX58, SWAP70, and TAGLN2 protein expression in the aortic tissues of AS and control mice, with GAPDH used as a loading control. C , Quantification of DHX58, SWAP70, and TAGLN2 protein levels in the aortic tissues of AS and control mice. Data are presented as mean±SE (n=6 per group, analyzed using the Mann‐Whitney U test). D , Quantification of DHX58, SWAP70 , and TAGLN2 mRNA levels in the aortic tissues of AS and control mice. Data are presented as mean±SE (n=6 per group, analyzed using the Mann‐Whitney U test). AS indicates atherosclerotic. KD, kiloDalton.

Article Snippet: Membranes were incubated with the following primary antibodies: DHX58 (1:500, Proteintech, 10 494‐1‐AP), SWAP70 (1:1000, Abclonal, A14857), TAGLN2 (1:2000, Proteintech, 10 234‐2‐AP), and GAPDH (1:20000, Proteintech, 10 494‐1‐AP), which served as the loading control.

Techniques: Staining, Western Blot, Expressing, Control, MANN-WHITNEY