6 7 dichloro 1h indole 2  (Millipore)

 
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    Name:
    Dichloro dimethylglyoximato dimethylglyoxime rhodium III
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    Catalog Number:
    479802
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    Structured Review

    Millipore 6 7 dichloro 1h indole 2
    Dichloro dimethylglyoximato dimethylglyoxime rhodium III

    https://www.bioz.com/result/6 7 dichloro 1h indole 2/product/Millipore
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    6 7 dichloro 1h indole 2 - by Bioz Stars, 2021-09
    91/100 stars

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    other:

    Article Title: Endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexes
    Article Snippet: 6, 7-dichloro-1H-indole-2,3-dione 3-oxime (NS309), naphtho[1,2-d]thiazol-2-ylamine (SKA-31) and 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34) were purchased from Sigma Aldrich and dissolved in dimethyl sulfoxide (DMSO).

    Article Title: Daily variation in the electrophysiological activity of mouse medial habenula neurones
    Article Snippet: NS309 was initially dissolved in dimethyl sulphoxide (DMSO) (Sigma) and during the experiments stock solutions were diluted in recording aCSF and bath applied in the perfusing aCSF.

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  • 92
    Millipore ns309
    K Ca channel activators <t>NS309</t> and DCEBIO enhance agonist-evoked increases in NO synthesis and intracellular Ca 2+ transients in isolated human vascular endothelial cells. A ) Microfluorimetric tracing of ATP-evoked increases in acute NO production
    Ns309, supplied by Millipore, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ns309/product/Millipore
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ns309 - by Bioz Stars, 2021-09
    92/100 stars
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    99
    Millipore dye 2 7 dichloro dihydro fluorescein diacetate
    K Ca channel activators <t>NS309</t> and DCEBIO enhance agonist-evoked increases in NO synthesis and intracellular Ca 2+ transients in isolated human vascular endothelial cells. A ) Microfluorimetric tracing of ATP-evoked increases in acute NO production
    Dye 2 7 Dichloro Dihydro Fluorescein Diacetate, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dye 2 7 dichloro dihydro fluorescein diacetate/product/Millipore
    Average 99 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    dye 2 7 dichloro dihydro fluorescein diacetate - by Bioz Stars, 2021-09
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    K Ca channel activators NS309 and DCEBIO enhance agonist-evoked increases in NO synthesis and intracellular Ca 2+ transients in isolated human vascular endothelial cells. A ) Microfluorimetric tracing of ATP-evoked increases in acute NO production

    Journal: The FASEB Journal

    Article Title: Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation

    doi: 10.1096/fj.08-120451

    Figure Lengend Snippet: K Ca channel activators NS309 and DCEBIO enhance agonist-evoked increases in NO synthesis and intracellular Ca 2+ transients in isolated human vascular endothelial cells. A ) Microfluorimetric tracing of ATP-evoked increases in acute NO production

    Article Snippet: NS309 (3-oxime-6,7-dichloro-1H-indole-2,3-dione), DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one), ATP (adenosine 5′-triphosphate disodium salt), apamin, l -NAME, and chemicals to prepare physiological saline solutions were purchased from Sigma-Aldrich (St. Louis, MO) and were of ACS grade or higher.

    Techniques: Isolation

    K Ca channel openers NS309 and DCEBIO evoke relaxation of myogenic tone in pressurized rat cremaster arterioles and enhance vasodilation in response to acetylcholine. A ) Pressurized vessels were briefly exposed (∼1 min) to increasing concentrations

    Journal: The FASEB Journal

    Article Title: Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation

    doi: 10.1096/fj.08-120451

    Figure Lengend Snippet: K Ca channel openers NS309 and DCEBIO evoke relaxation of myogenic tone in pressurized rat cremaster arterioles and enhance vasodilation in response to acetylcholine. A ) Pressurized vessels were briefly exposed (∼1 min) to increasing concentrations

    Article Snippet: NS309 (3-oxime-6,7-dichloro-1H-indole-2,3-dione), DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one), ATP (adenosine 5′-triphosphate disodium salt), apamin, l -NAME, and chemicals to prepare physiological saline solutions were purchased from Sigma-Aldrich (St. Louis, MO) and were of ACS grade or higher.

    Techniques:

    NS309- and DCEBIO-induced relaxation of myogenic tone in pressurized rat cremaster arterioles is unaffected by eNOS inhibitor l -NAME, but abolished by functional disruption of vascular endothelium. A ) Vasodilatory responses of pressurized arterioles briefly

    Journal: The FASEB Journal

    Article Title: Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation

    doi: 10.1096/fj.08-120451

    Figure Lengend Snippet: NS309- and DCEBIO-induced relaxation of myogenic tone in pressurized rat cremaster arterioles is unaffected by eNOS inhibitor l -NAME, but abolished by functional disruption of vascular endothelium. A ) Vasodilatory responses of pressurized arterioles briefly

    Article Snippet: NS309 (3-oxime-6,7-dichloro-1H-indole-2,3-dione), DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one), ATP (adenosine 5′-triphosphate disodium salt), apamin, l -NAME, and chemicals to prepare physiological saline solutions were purchased from Sigma-Aldrich (St. Louis, MO) and were of ACS grade or higher.

    Techniques: Functional Assay

    Membrane hyperpolarizations evoked by NS309 and ATP, either alone or in combination, are blocked in the presence of apamin and TRAM-34. A , B ) Representative perforated patch-clamp recordings of membrane potential changes in a single human vascular endothelial

    Journal: The FASEB Journal

    Article Title: Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation

    doi: 10.1096/fj.08-120451

    Figure Lengend Snippet: Membrane hyperpolarizations evoked by NS309 and ATP, either alone or in combination, are blocked in the presence of apamin and TRAM-34. A , B ) Representative perforated patch-clamp recordings of membrane potential changes in a single human vascular endothelial

    Article Snippet: NS309 (3-oxime-6,7-dichloro-1H-indole-2,3-dione), DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one), ATP (adenosine 5′-triphosphate disodium salt), apamin, l -NAME, and chemicals to prepare physiological saline solutions were purchased from Sigma-Aldrich (St. Louis, MO) and were of ACS grade or higher.

    Techniques: Patch Clamp

    NS309 and DCEBIO induce membrane hyperpolarization and enhance hyperpolarizing responses evoked by ATP in single human endothelial cells. A ) ATP-evoked changes in membrane potential were recorded using perforated patch-clamp methodology in absence and

    Journal: The FASEB Journal

    Article Title: Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation

    doi: 10.1096/fj.08-120451

    Figure Lengend Snippet: NS309 and DCEBIO induce membrane hyperpolarization and enhance hyperpolarizing responses evoked by ATP in single human endothelial cells. A ) ATP-evoked changes in membrane potential were recorded using perforated patch-clamp methodology in absence and

    Article Snippet: NS309 (3-oxime-6,7-dichloro-1H-indole-2,3-dione), DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one), ATP (adenosine 5′-triphosphate disodium salt), apamin, l -NAME, and chemicals to prepare physiological saline solutions were purchased from Sigma-Aldrich (St. Louis, MO) and were of ACS grade or higher.

    Techniques: Patch Clamp

    Role of small (SK) and intermediate (IK) conductance potassium channels preconditioning. Effects of I/R alone, I/R following pretreatment with a H 2 S donor (NaHS + I/R), SK or IK channel inhibition with apamin or TRAM-34, respectively, just before treatment with H 2 S donor (apamin + NaHS + I/R; or TRAM-34 + NaHS + I/R), or preconditioning with the SK/IK activator NS-309, in lieu of NaHS (NS-309 + I/R), on postischemic leukocyte rolling ( A ) or stationary leukocyte adhesion ( B ) determined after 30 and 60 min of reperfusion ( n = 6 in all groups). *Mean values that were statistically different from the NaHS + IR group.

    Journal: American Journal of Physiology - Heart and Circulatory Physiology

    Article Title: Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of BK channels

    doi: 10.1152/ajpheart.01229.2009

    Figure Lengend Snippet: Role of small (SK) and intermediate (IK) conductance potassium channels preconditioning. Effects of I/R alone, I/R following pretreatment with a H 2 S donor (NaHS + I/R), SK or IK channel inhibition with apamin or TRAM-34, respectively, just before treatment with H 2 S donor (apamin + NaHS + I/R; or TRAM-34 + NaHS + I/R), or preconditioning with the SK/IK activator NS-309, in lieu of NaHS (NS-309 + I/R), on postischemic leukocyte rolling ( A ) or stationary leukocyte adhesion ( B ) determined after 30 and 60 min of reperfusion ( n = 6 in all groups). *Mean values that were statistically different from the NaHS + IR group.

    Article Snippet: To determine whether activation of IK and SK would mimic the effects of NaHS-PC, mice in this group ( n = 6) were treated as described for group 6, except that NS-309 (Sigma Chemical), an IKCa and SKCa agonist, was administered (1 mg/kg in 2% DMSO saline mixture, 100 μM, 0.5 ml ip) in lieu of NaHS.

    Techniques: Inhibition

    Summary of suggested pathways for the activation of K Ca channels and generation of EDHF. ACh leads to a global increase in [Ca 2+ ] i as a consequence of Ca 2+ release from inositol trisphosphate (IP 3 ) sensitive Ca 2+ stores within endothelial cells. The rise in [Ca 2+ ] i triggers the activation of IK Ca and SK Ca and consequently the generation of EDHF response. Depletion of intracellular stores triggers Ca 2+ entry via TRP channels, which consequently participates in the global increase of [Ca 2+ ] i .(1). K Ca are possibly localized in close vicinity to TRP channels. The opening of TRP channels maintains some level of localized increase in [Ca 2+ ] i , which is essential for K Ca channels to be activated by NS309 (2).

    Journal: Journal of Advanced Research

    Article Title: The effect of streptozotocin-induced diabetes on the EDHF-type relaxation and cardiac function in rats

    doi: 10.1016/j.jare.2012.07.005

    Figure Lengend Snippet: Summary of suggested pathways for the activation of K Ca channels and generation of EDHF. ACh leads to a global increase in [Ca 2+ ] i as a consequence of Ca 2+ release from inositol trisphosphate (IP 3 ) sensitive Ca 2+ stores within endothelial cells. The rise in [Ca 2+ ] i triggers the activation of IK Ca and SK Ca and consequently the generation of EDHF response. Depletion of intracellular stores triggers Ca 2+ entry via TRP channels, which consequently participates in the global increase of [Ca 2+ ] i .(1). K Ca are possibly localized in close vicinity to TRP channels. The opening of TRP channels maintains some level of localized increase in [Ca 2+ ] i , which is essential for K Ca channels to be activated by NS309 (2).

    Article Snippet: Drugs Acetylcholine (ACh; as chloride salt), indomethacin, NG -nitro-L-arginine, NS309 (3-oxime-6,7-dichloro-1H-indole-2,3-dione) and ruthenium red were from Sigma–Aldrich, UK.

    Techniques: Activation Assay

    Changes (in%) of NS309-induced responses of mesenteric arteries from control and diabetic rats in response to NS309. (A) NS309 (1 μM)-induced relaxations were reduced in diabetics arteries. The IK Ca response, in the presence of 100 nM apamin (B) and the SK Ca response, in presence of 1 μM TRAM-34 (C) were also affected by diabetes. Relaxations of arteries mediated by NS309, opening of IK Ca (B) or SK Ca (C) were markedly reduced by RuR. Results shown are means ± s.e.mean ( n ⩾ 5). One-way ANOVA; * P

    Journal: Journal of Advanced Research

    Article Title: The effect of streptozotocin-induced diabetes on the EDHF-type relaxation and cardiac function in rats

    doi: 10.1016/j.jare.2012.07.005

    Figure Lengend Snippet: Changes (in%) of NS309-induced responses of mesenteric arteries from control and diabetic rats in response to NS309. (A) NS309 (1 μM)-induced relaxations were reduced in diabetics arteries. The IK Ca response, in the presence of 100 nM apamin (B) and the SK Ca response, in presence of 1 μM TRAM-34 (C) were also affected by diabetes. Relaxations of arteries mediated by NS309, opening of IK Ca (B) or SK Ca (C) were markedly reduced by RuR. Results shown are means ± s.e.mean ( n ⩾ 5). One-way ANOVA; * P

    Article Snippet: Drugs Acetylcholine (ACh; as chloride salt), indomethacin, NG -nitro-L-arginine, NS309 (3-oxime-6,7-dichloro-1H-indole-2,3-dione) and ruthenium red were from Sigma–Aldrich, UK.

    Techniques: