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FGF4 alleviated the damage of lung cells caused by hyperglycemia. (A) Cell proliferation is promoted by FGF4 treatment. (B) The effect of FGF4 on the expression <t>of</t> <t>cyclinD1</t> and <t>PCNA</t> in cells. (C) The effect of FGF4 on the expression of p21 and p53. * P<0.05, ** P<0.01, *** P<0.001. FGF4, fibroblast growth factor 4; PCNA, proliferating cell nuclear antigen.
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FGF4 alleviated the damage of lung cells caused by hyperglycemia. (A) Cell proliferation is promoted by FGF4 treatment. (B) The effect of FGF4 on the expression <t>of</t> <t>cyclinD1</t> and <t>PCNA</t> in cells. (C) The effect of FGF4 on the expression of p21 and p53. * P<0.05, ** P<0.01, *** P<0.001. FGF4, fibroblast growth factor 4; PCNA, proliferating cell nuclear antigen.
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FGF4 alleviated the damage of lung cells caused by hyperglycemia. (A) Cell proliferation is promoted by FGF4 treatment. (B) The effect of FGF4 on the expression <t>of</t> <t>cyclinD1</t> and <t>PCNA</t> in cells. (C) The effect of FGF4 on the expression of p21 and p53. * P<0.05, ** P<0.01, *** P<0.001. FGF4, fibroblast growth factor 4; PCNA, proliferating cell nuclear antigen.
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FGF4 alleviated the damage of lung cells caused by hyperglycemia. (A) Cell proliferation is promoted by FGF4 treatment. (B) The effect of FGF4 on the expression <t>of</t> <t>cyclinD1</t> and <t>PCNA</t> in cells. (C) The effect of FGF4 on the expression of p21 and p53. * P<0.05, ** P<0.01, *** P<0.001. FGF4, fibroblast growth factor 4; PCNA, proliferating cell nuclear antigen.
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FGF4 alleviated the damage of lung cells caused by hyperglycemia. (A) Cell proliferation is promoted by FGF4 treatment. (B) The effect of FGF4 on the expression <t>of</t> <t>cyclinD1</t> and <t>PCNA</t> in cells. (C) The effect of FGF4 on the expression of p21 and p53. * P<0.05, ** P<0.01, *** P<0.001. FGF4, fibroblast growth factor 4; PCNA, proliferating cell nuclear antigen.
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FGF4 alleviated the damage of lung cells caused by hyperglycemia. (A) Cell proliferation is promoted by FGF4 treatment. (B) The effect of FGF4 on the expression <t>of</t> <t>cyclinD1</t> and <t>PCNA</t> in cells. (C) The effect of FGF4 on the expression of p21 and p53. * P<0.05, ** P<0.01, *** P<0.001. FGF4, fibroblast growth factor 4; PCNA, proliferating cell nuclear antigen.
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FGF4 alleviated the damage of lung cells caused by hyperglycemia. (A) Cell proliferation is promoted by FGF4 treatment. (B) The effect of FGF4 on the expression <t>of</t> <t>cyclinD1</t> and <t>PCNA</t> in cells. (C) The effect of FGF4 on the expression of p21 and p53. * P<0.05, ** P<0.01, *** P<0.001. FGF4, fibroblast growth factor 4; PCNA, proliferating cell nuclear antigen.
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FGF4 alleviated the damage of lung cells caused by hyperglycemia. (A) Cell proliferation is promoted by FGF4 treatment. (B) The effect of FGF4 on the expression of cyclinD1 and PCNA in cells. (C) The effect of FGF4 on the expression of p21 and p53. * P<0.05, ** P<0.01, *** P<0.001. FGF4, fibroblast growth factor 4; PCNA, proliferating cell nuclear antigen.

Journal: International Journal of Molecular Medicine

Article Title: FGF4 alleviates the lung cell damage caused by high glucose via AMPK-PGC-1 signaling axis in vitro and in vivo

doi: 10.3892/ijmm.2025.5710

Figure Lengend Snippet: FGF4 alleviated the damage of lung cells caused by hyperglycemia. (A) Cell proliferation is promoted by FGF4 treatment. (B) The effect of FGF4 on the expression of cyclinD1 and PCNA in cells. (C) The effect of FGF4 on the expression of p21 and p53. * P<0.05, ** P<0.01, *** P<0.001. FGF4, fibroblast growth factor 4; PCNA, proliferating cell nuclear antigen.

Article Snippet: CyclinD1, proliferating cell nuclear antigen (PCNA), phosphorylated (p-)IκB, p-P65 and p-STAT3 were from Proteintech Group, Inc. malondialdehyde (MDA; cat. no. A003-1-2), SOD (cat. no. A001-3-2) and glutathione peroxidase (GPX; cat. no. H545-1-1) were from Nanjing Jiancheng Bioengineering Institute.

Techniques: Expressing