Review





Similar Products

monoclonal antibody cocktail  (Chondrex Inc)
94
Chondrex Inc monoclonal antibody cocktail
Monoclonal Antibody Cocktail, supplied by Chondrex Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/53010/pm42097460-76-18-21?v=Chondrex+Inc
Average 94 stars, based on 1 article reviews
monoclonal antibody cocktail - by Bioz Stars, 2026-07
94/100 stars
  Buy from Supplier
lipopolysaccharide  (Chondrex Inc)
94
Chondrex Inc lipopolysaccharide
Elimination of senescent cells contributes to the alleviation of experimental synovitis. a , Differential gene expression analysis comparing synovial fibroblasts (SF) depleted of APOC1 or negative control. Blue points, genes with significantly decreased expression (false discovery rate (FDR) < 0.01); black labels, marker genes of p16 h -sn fibroblast from Meguro et al . b , Enrichment of p16 h -sn fibroblast marker genes in APOC1 -depleted SF relative to negative control, calculated by Gene Set Enrichment Analysis (GSEA) . c , Experimental design of the collagen antibody-induced arthritis (CAIA) mouse model using 7-8 week-old male p16-Cre ERT2 -DTR mice or p16-Cre ERT2 mice (control). Starting at the time of arthritis induction, mice received intraperitoneal injections of tamoxifen 80 mg/kg and diphtheria toxin 25 μ g/kg twice daily. d , Clinical arthritis scores of p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). e , Ratio of eroded surface to total surface area of left ankle joints in p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition, assessed by micro-computed tomography (micro-CT). Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). f , Experimental design of the CAIA mouse model using 7-week-old male DBA/1J wild-type mice treated with the TNF inhibitor etanercept and/or the senolytic agent ABT-263. Following arthritis onset, mice received intraperitoneal injections of vehicle or etanercept 2 mg/kg twice daily and oral administration of vehicle or ABT-263 100 mg/kg once daily. g , Clinical arthritis scores of mice treated with etanercept plus ABT-263 (n = 9), etanercept alone (n = 9), ABT-263 alone (n = 8) or vehicle (n = 9) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p < 0.01 versus vehicle; # p < 0.05 for etanercept plus ABT-263 versus etanercept alone). h , Ratio of eroded surface to total surface area of left ankle joints in mice treated with etanercept plus ABT-263 (n = 9) or etanercept alone (n = 9) under CAIA condition, assessed by micro-CT. Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). CAIA, collagen antibody-induced arthritis; CT, computed tomography; DT, diphtheria toxin; DTR, diphtheria toxin receptor; FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; ip, intraperitoneal; iv, intravenous; KO, knock out; LPS, <t>lipopolysaccharide;</t> po, per os; SD, standard deviation; SF, synovial fibroblast; sn, senescent.
Lipopolysaccharide, supplied by Chondrex Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/53010/bio_rxiv__64898__2026__04__17__718831-350-22-28?v=Chondrex+Inc
Average 94 stars, based on 1 article reviews
lipopolysaccharide - by Bioz Stars, 2026-07
94/100 stars
  Buy from Supplier
anti collagen monoclonal antibody cocktail  (Chondrex Inc)
94
Chondrex Inc anti collagen monoclonal antibody cocktail
Elimination of senescent cells contributes to the alleviation of experimental synovitis. a , Differential gene expression analysis comparing synovial fibroblasts (SF) depleted of APOC1 or negative control. Blue points, genes with significantly decreased expression (false discovery rate (FDR) < 0.01); black labels, marker genes of p16 h -sn fibroblast from Meguro et al . b , Enrichment of p16 h -sn fibroblast marker genes in APOC1 -depleted SF relative to negative control, calculated by Gene Set Enrichment Analysis (GSEA) . c , Experimental design of the collagen antibody-induced arthritis (CAIA) mouse model using 7-8 week-old male p16-Cre ERT2 -DTR mice or p16-Cre ERT2 mice (control). Starting at the time of arthritis induction, mice received intraperitoneal injections of tamoxifen 80 mg/kg and diphtheria toxin 25 μ g/kg twice daily. d , Clinical arthritis scores of p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). e , Ratio of eroded surface to total surface area of left ankle joints in p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition, assessed by micro-computed tomography (micro-CT). Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). f , Experimental design of the CAIA mouse model using 7-week-old male DBA/1J wild-type mice treated with the TNF inhibitor etanercept and/or the senolytic agent ABT-263. Following arthritis onset, mice received intraperitoneal injections of vehicle or etanercept 2 mg/kg twice daily and oral administration of vehicle or ABT-263 100 mg/kg once daily. g , Clinical arthritis scores of mice treated with etanercept plus ABT-263 (n = 9), etanercept alone (n = 9), ABT-263 alone (n = 8) or vehicle (n = 9) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p < 0.01 versus vehicle; # p < 0.05 for etanercept plus ABT-263 versus etanercept alone). h , Ratio of eroded surface to total surface area of left ankle joints in mice treated with etanercept plus ABT-263 (n = 9) or etanercept alone (n = 9) under CAIA condition, assessed by micro-CT. Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). CAIA, collagen antibody-induced arthritis; CT, computed tomography; DT, diphtheria toxin; DTR, diphtheria toxin receptor; FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; ip, intraperitoneal; iv, intravenous; KO, knock out; LPS, <t>lipopolysaccharide;</t> po, per os; SD, standard deviation; SF, synovial fibroblast; sn, senescent.
Anti Collagen Monoclonal Antibody Cocktail, supplied by Chondrex Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/53010/bio_rxiv__64898__2026__04__17__718831-349-10-18?v=Chondrex+Inc
Average 94 stars, based on 1 article reviews
anti collagen monoclonal antibody cocktail - by Bioz Stars, 2026-07
94/100 stars
  Buy from Supplier
anti collagen antibodies  (Chondrex Inc)
94
Chondrex Inc anti collagen antibodies
Elimination of senescent cells contributes to the alleviation of experimental synovitis. a , Differential gene expression analysis comparing synovial fibroblasts (SF) depleted of APOC1 or negative control. Blue points, genes with significantly decreased expression (false discovery rate (FDR) < 0.01); black labels, marker genes of p16 h -sn fibroblast from Meguro et al . b , Enrichment of p16 h -sn fibroblast marker genes in APOC1 -depleted SF relative to negative control, calculated by Gene Set Enrichment Analysis (GSEA) . c , Experimental design of the collagen antibody-induced arthritis (CAIA) mouse model using 7-8 week-old male p16-Cre ERT2 -DTR mice or p16-Cre ERT2 mice (control). Starting at the time of arthritis induction, mice received intraperitoneal injections of tamoxifen 80 mg/kg and diphtheria toxin 25 μ g/kg twice daily. d , Clinical arthritis scores of p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). e , Ratio of eroded surface to total surface area of left ankle joints in p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition, assessed by micro-computed tomography (micro-CT). Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). f , Experimental design of the CAIA mouse model using 7-week-old male DBA/1J wild-type mice treated with the TNF inhibitor etanercept and/or the senolytic agent ABT-263. Following arthritis onset, mice received intraperitoneal injections of vehicle or etanercept 2 mg/kg twice daily and oral administration of vehicle or ABT-263 100 mg/kg once daily. g , Clinical arthritis scores of mice treated with etanercept plus ABT-263 (n = 9), etanercept alone (n = 9), ABT-263 alone (n = 8) or vehicle (n = 9) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p < 0.01 versus vehicle; # p < 0.05 for etanercept plus ABT-263 versus etanercept alone). h , Ratio of eroded surface to total surface area of left ankle joints in mice treated with etanercept plus ABT-263 (n = 9) or etanercept alone (n = 9) under CAIA condition, assessed by micro-CT. Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). CAIA, collagen antibody-induced arthritis; CT, computed tomography; DT, diphtheria toxin; DTR, diphtheria toxin receptor; FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; ip, intraperitoneal; iv, intravenous; KO, knock out; LPS, <t>lipopolysaccharide;</t> po, per os; SD, standard deviation; SF, synovial fibroblast; sn, senescent.
Anti Collagen Antibodies, supplied by Chondrex Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/53010/pm42010292-347-10-16?v=Chondrex+Inc
Average 94 stars, based on 1 article reviews
anti collagen antibodies - by Bioz Stars, 2026-07
94/100 stars
  Buy from Supplier
lps  (Chondrex Inc)
94
Chondrex Inc lps
Elimination of senescent cells contributes to the alleviation of experimental synovitis. a , Differential gene expression analysis comparing synovial fibroblasts (SF) depleted of APOC1 or negative control. Blue points, genes with significantly decreased expression (false discovery rate (FDR) < 0.01); black labels, marker genes of p16 h -sn fibroblast from Meguro et al . b , Enrichment of p16 h -sn fibroblast marker genes in APOC1 -depleted SF relative to negative control, calculated by Gene Set Enrichment Analysis (GSEA) . c , Experimental design of the collagen antibody-induced arthritis (CAIA) mouse model using 7-8 week-old male p16-Cre ERT2 -DTR mice or p16-Cre ERT2 mice (control). Starting at the time of arthritis induction, mice received intraperitoneal injections of tamoxifen 80 mg/kg and diphtheria toxin 25 μ g/kg twice daily. d , Clinical arthritis scores of p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). e , Ratio of eroded surface to total surface area of left ankle joints in p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition, assessed by micro-computed tomography (micro-CT). Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). f , Experimental design of the CAIA mouse model using 7-week-old male DBA/1J wild-type mice treated with the TNF inhibitor etanercept and/or the senolytic agent ABT-263. Following arthritis onset, mice received intraperitoneal injections of vehicle or etanercept 2 mg/kg twice daily and oral administration of vehicle or ABT-263 100 mg/kg once daily. g , Clinical arthritis scores of mice treated with etanercept plus ABT-263 (n = 9), etanercept alone (n = 9), ABT-263 alone (n = 8) or vehicle (n = 9) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p < 0.01 versus vehicle; # p < 0.05 for etanercept plus ABT-263 versus etanercept alone). h , Ratio of eroded surface to total surface area of left ankle joints in mice treated with etanercept plus ABT-263 (n = 9) or etanercept alone (n = 9) under CAIA condition, assessed by micro-CT. Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). CAIA, collagen antibody-induced arthritis; CT, computed tomography; DT, diphtheria toxin; DTR, diphtheria toxin receptor; FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; ip, intraperitoneal; iv, intravenous; KO, knock out; LPS, <t>lipopolysaccharide;</t> po, per os; SD, standard deviation; SF, synovial fibroblast; sn, senescent.
Lps, supplied by Chondrex Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/53010/pm42001211-59-8-10?v=Chondrex+Inc
Average 94 stars, based on 1 article reviews
lps - by Bioz Stars, 2026-07
94/100 stars
  Buy from Supplier
mouse igg1 anti serca2  (Santa Cruz Biotechnology)
94
Santa Cruz Biotechnology mouse igg1 anti serca2
Elimination of senescent cells contributes to the alleviation of experimental synovitis. a , Differential gene expression analysis comparing synovial fibroblasts (SF) depleted of APOC1 or negative control. Blue points, genes with significantly decreased expression (false discovery rate (FDR) < 0.01); black labels, marker genes of p16 h -sn fibroblast from Meguro et al . b , Enrichment of p16 h -sn fibroblast marker genes in APOC1 -depleted SF relative to negative control, calculated by Gene Set Enrichment Analysis (GSEA) . c , Experimental design of the collagen antibody-induced arthritis (CAIA) mouse model using 7-8 week-old male p16-Cre ERT2 -DTR mice or p16-Cre ERT2 mice (control). Starting at the time of arthritis induction, mice received intraperitoneal injections of tamoxifen 80 mg/kg and diphtheria toxin 25 μ g/kg twice daily. d , Clinical arthritis scores of p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). e , Ratio of eroded surface to total surface area of left ankle joints in p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition, assessed by micro-computed tomography (micro-CT). Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). f , Experimental design of the CAIA mouse model using 7-week-old male DBA/1J wild-type mice treated with the TNF inhibitor etanercept and/or the senolytic agent ABT-263. Following arthritis onset, mice received intraperitoneal injections of vehicle or etanercept 2 mg/kg twice daily and oral administration of vehicle or ABT-263 100 mg/kg once daily. g , Clinical arthritis scores of mice treated with etanercept plus ABT-263 (n = 9), etanercept alone (n = 9), ABT-263 alone (n = 8) or vehicle (n = 9) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p < 0.01 versus vehicle; # p < 0.05 for etanercept plus ABT-263 versus etanercept alone). h , Ratio of eroded surface to total surface area of left ankle joints in mice treated with etanercept plus ABT-263 (n = 9) or etanercept alone (n = 9) under CAIA condition, assessed by micro-CT. Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). CAIA, collagen antibody-induced arthritis; CT, computed tomography; DT, diphtheria toxin; DTR, diphtheria toxin receptor; FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; ip, intraperitoneal; iv, intravenous; KO, knock out; LPS, <t>lipopolysaccharide;</t> po, per os; SD, standard deviation; SF, synovial fibroblast; sn, senescent.
Mouse Igg1 Anti Serca2, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/53010/bio_rxiv__64898__2026__02__16__706166-76-14-19?v=Santa+Cruz+Biotechnology
Average 94 stars, based on 1 article reviews
mouse igg1 anti serca2 - by Bioz Stars, 2026-07
94/100 stars
  Buy from Supplier
rabbit anti dystrophin  (Santa Cruz Biotechnology)
94
Santa Cruz Biotechnology rabbit anti dystrophin
Elimination of senescent cells contributes to the alleviation of experimental synovitis. a , Differential gene expression analysis comparing synovial fibroblasts (SF) depleted of APOC1 or negative control. Blue points, genes with significantly decreased expression (false discovery rate (FDR) < 0.01); black labels, marker genes of p16 h -sn fibroblast from Meguro et al . b , Enrichment of p16 h -sn fibroblast marker genes in APOC1 -depleted SF relative to negative control, calculated by Gene Set Enrichment Analysis (GSEA) . c , Experimental design of the collagen antibody-induced arthritis (CAIA) mouse model using 7-8 week-old male p16-Cre ERT2 -DTR mice or p16-Cre ERT2 mice (control). Starting at the time of arthritis induction, mice received intraperitoneal injections of tamoxifen 80 mg/kg and diphtheria toxin 25 μ g/kg twice daily. d , Clinical arthritis scores of p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). e , Ratio of eroded surface to total surface area of left ankle joints in p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition, assessed by micro-computed tomography (micro-CT). Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). f , Experimental design of the CAIA mouse model using 7-week-old male DBA/1J wild-type mice treated with the TNF inhibitor etanercept and/or the senolytic agent ABT-263. Following arthritis onset, mice received intraperitoneal injections of vehicle or etanercept 2 mg/kg twice daily and oral administration of vehicle or ABT-263 100 mg/kg once daily. g , Clinical arthritis scores of mice treated with etanercept plus ABT-263 (n = 9), etanercept alone (n = 9), ABT-263 alone (n = 8) or vehicle (n = 9) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p < 0.01 versus vehicle; # p < 0.05 for etanercept plus ABT-263 versus etanercept alone). h , Ratio of eroded surface to total surface area of left ankle joints in mice treated with etanercept plus ABT-263 (n = 9) or etanercept alone (n = 9) under CAIA condition, assessed by micro-CT. Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). CAIA, collagen antibody-induced arthritis; CT, computed tomography; DT, diphtheria toxin; DTR, diphtheria toxin receptor; FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; ip, intraperitoneal; iv, intravenous; KO, knock out; LPS, <t>lipopolysaccharide;</t> po, per os; SD, standard deviation; SF, synovial fibroblast; sn, senescent.
Rabbit Anti Dystrophin, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/53010/bio_rxiv__64898__2026__02__16__706166-76-24-19?v=Santa+Cruz+Biotechnology
Average 94 stars, based on 1 article reviews
rabbit anti dystrophin - by Bioz Stars, 2026-07
94/100 stars
  Buy from Supplier
serca2a  (Santa Cruz Biotechnology)
94
Santa Cruz Biotechnology serca2a
Elimination of senescent cells contributes to the alleviation of experimental synovitis. a , Differential gene expression analysis comparing synovial fibroblasts (SF) depleted of APOC1 or negative control. Blue points, genes with significantly decreased expression (false discovery rate (FDR) < 0.01); black labels, marker genes of p16 h -sn fibroblast from Meguro et al . b , Enrichment of p16 h -sn fibroblast marker genes in APOC1 -depleted SF relative to negative control, calculated by Gene Set Enrichment Analysis (GSEA) . c , Experimental design of the collagen antibody-induced arthritis (CAIA) mouse model using 7-8 week-old male p16-Cre ERT2 -DTR mice or p16-Cre ERT2 mice (control). Starting at the time of arthritis induction, mice received intraperitoneal injections of tamoxifen 80 mg/kg and diphtheria toxin 25 μ g/kg twice daily. d , Clinical arthritis scores of p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). e , Ratio of eroded surface to total surface area of left ankle joints in p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition, assessed by micro-computed tomography (micro-CT). Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). f , Experimental design of the CAIA mouse model using 7-week-old male DBA/1J wild-type mice treated with the TNF inhibitor etanercept and/or the senolytic agent ABT-263. Following arthritis onset, mice received intraperitoneal injections of vehicle or etanercept 2 mg/kg twice daily and oral administration of vehicle or ABT-263 100 mg/kg once daily. g , Clinical arthritis scores of mice treated with etanercept plus ABT-263 (n = 9), etanercept alone (n = 9), ABT-263 alone (n = 8) or vehicle (n = 9) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p < 0.01 versus vehicle; # p < 0.05 for etanercept plus ABT-263 versus etanercept alone). h , Ratio of eroded surface to total surface area of left ankle joints in mice treated with etanercept plus ABT-263 (n = 9) or etanercept alone (n = 9) under CAIA condition, assessed by micro-CT. Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). CAIA, collagen antibody-induced arthritis; CT, computed tomography; DT, diphtheria toxin; DTR, diphtheria toxin receptor; FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; ip, intraperitoneal; iv, intravenous; KO, knock out; LPS, <t>lipopolysaccharide;</t> po, per os; SD, standard deviation; SF, synovial fibroblast; sn, senescent.
Serca2a, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/53010/pm41618855-378-57-58?v=Santa+Cruz+Biotechnology
Average 94 stars, based on 1 article reviews
serca2a - by Bioz Stars, 2026-07
94/100 stars
  Buy from Supplier

Image Search Results


Elimination of senescent cells contributes to the alleviation of experimental synovitis. a , Differential gene expression analysis comparing synovial fibroblasts (SF) depleted of APOC1 or negative control. Blue points, genes with significantly decreased expression (false discovery rate (FDR) < 0.01); black labels, marker genes of p16 h -sn fibroblast from Meguro et al . b , Enrichment of p16 h -sn fibroblast marker genes in APOC1 -depleted SF relative to negative control, calculated by Gene Set Enrichment Analysis (GSEA) . c , Experimental design of the collagen antibody-induced arthritis (CAIA) mouse model using 7-8 week-old male p16-Cre ERT2 -DTR mice or p16-Cre ERT2 mice (control). Starting at the time of arthritis induction, mice received intraperitoneal injections of tamoxifen 80 mg/kg and diphtheria toxin 25 μ g/kg twice daily. d , Clinical arthritis scores of p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). e , Ratio of eroded surface to total surface area of left ankle joints in p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition, assessed by micro-computed tomography (micro-CT). Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). f , Experimental design of the CAIA mouse model using 7-week-old male DBA/1J wild-type mice treated with the TNF inhibitor etanercept and/or the senolytic agent ABT-263. Following arthritis onset, mice received intraperitoneal injections of vehicle or etanercept 2 mg/kg twice daily and oral administration of vehicle or ABT-263 100 mg/kg once daily. g , Clinical arthritis scores of mice treated with etanercept plus ABT-263 (n = 9), etanercept alone (n = 9), ABT-263 alone (n = 8) or vehicle (n = 9) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p < 0.01 versus vehicle; # p < 0.05 for etanercept plus ABT-263 versus etanercept alone). h , Ratio of eroded surface to total surface area of left ankle joints in mice treated with etanercept plus ABT-263 (n = 9) or etanercept alone (n = 9) under CAIA condition, assessed by micro-CT. Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). CAIA, collagen antibody-induced arthritis; CT, computed tomography; DT, diphtheria toxin; DTR, diphtheria toxin receptor; FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; ip, intraperitoneal; iv, intravenous; KO, knock out; LPS, lipopolysaccharide; po, per os; SD, standard deviation; SF, synovial fibroblast; sn, senescent.

Journal: bioRxiv

Article Title: A senescent iCAF-like fibroblast state governs therapy resistance in rheumatoid arthritis

doi: 10.64898/2026.04.17.718831

Figure Lengend Snippet: Elimination of senescent cells contributes to the alleviation of experimental synovitis. a , Differential gene expression analysis comparing synovial fibroblasts (SF) depleted of APOC1 or negative control. Blue points, genes with significantly decreased expression (false discovery rate (FDR) < 0.01); black labels, marker genes of p16 h -sn fibroblast from Meguro et al . b , Enrichment of p16 h -sn fibroblast marker genes in APOC1 -depleted SF relative to negative control, calculated by Gene Set Enrichment Analysis (GSEA) . c , Experimental design of the collagen antibody-induced arthritis (CAIA) mouse model using 7-8 week-old male p16-Cre ERT2 -DTR mice or p16-Cre ERT2 mice (control). Starting at the time of arthritis induction, mice received intraperitoneal injections of tamoxifen 80 mg/kg and diphtheria toxin 25 μ g/kg twice daily. d , Clinical arthritis scores of p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). e , Ratio of eroded surface to total surface area of left ankle joints in p16-Cre ERT2 -DTR mice (n = 12) and p16-Cre ERT2 control mice (n = 13) under CAIA condition, assessed by micro-computed tomography (micro-CT). Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). f , Experimental design of the CAIA mouse model using 7-week-old male DBA/1J wild-type mice treated with the TNF inhibitor etanercept and/or the senolytic agent ABT-263. Following arthritis onset, mice received intraperitoneal injections of vehicle or etanercept 2 mg/kg twice daily and oral administration of vehicle or ABT-263 100 mg/kg once daily. g , Clinical arthritis scores of mice treated with etanercept plus ABT-263 (n = 9), etanercept alone (n = 9), ABT-263 alone (n = 8) or vehicle (n = 9) under CAIA condition. Dots, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p < 0.01 versus vehicle; # p < 0.05 for etanercept plus ABT-263 versus etanercept alone). h , Ratio of eroded surface to total surface area of left ankle joints in mice treated with etanercept plus ABT-263 (n = 9) or etanercept alone (n = 9) under CAIA condition, assessed by micro-CT. Bars, mean; error bars, SD. P values, two-tailed Mann-Whitney U test (* p <0.05). CAIA, collagen antibody-induced arthritis; CT, computed tomography; DT, diphtheria toxin; DTR, diphtheria toxin receptor; FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; ip, intraperitoneal; iv, intravenous; KO, knock out; LPS, lipopolysaccharide; po, per os; SD, standard deviation; SF, synovial fibroblast; sn, senescent.

Article Snippet: On day 3 and day 11, the p16-Cre ERT2 -tdTomato, p16-Cre ERT2 -DTR or p16-Cre ERT2 mice received additional i.p. injections of lipopolysaccharide (LPS; 50 μg per mouse, Chondrex, 53040).

Techniques: Gene Expression, Negative Control, Expressing, Marker, Control, Two Tailed Test, MANN-WHITNEY, Micro-CT, Computed Tomography, Knock-Out, Standard Deviation