implantable telemetry system  (TSE systems)


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    TSE systems implantable telemetry system
    S1PR1 pharmacological blockade, via <t>fingolimod,</t> inhibited renal inflammation and protected from renal injury in response to a high salt diet. (A) Representative flow cytometric gating strategy of kidney single-cell suspensions showing the effect of l -NAME followed by high salt exposure on total leukocytes (CD45 + expression), total T lymphocytes (CD3 + ), total CD8 + and CD4 + T cells, CD8 + and CD4 + CD44hi/CD62Llo (TEM cells) and CD44hi/CD62Lhi (TCM cells). SSC-A indicates a side scatter area. (B–E) Summary of flow cytometric quantification of absolute numbers of CD8 + and CD4 + TEM and TCM cells infiltrating the kidney in WT mice that received L-NAME + HS1+HS2±fingolimod. N = 9–16 mice/group. Normally distributed data are expressed as mean ± SEM (panels B, C and D); not normally distributed data are expressed as median ± IQR (panel E) (Supplementary table 1). p -values calculated by unpaired t -test were shown. ** p
    Implantable Telemetry System, supplied by TSE systems, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/implantable telemetry system/product/TSE systems
    Average 94 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    implantable telemetry system - by Bioz Stars, 2022-11
    94/100 stars

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    1) Product Images from "Sphingosine 1 phosphate promotes hypertension specific memory T cell trafficking in response to repeated hypertensive challenges"

    Article Title: Sphingosine 1 phosphate promotes hypertension specific memory T cell trafficking in response to repeated hypertensive challenges

    Journal: Frontiers in Physiology

    doi: 10.3389/fphys.2022.930487

    S1PR1 pharmacological blockade, via fingolimod, inhibited renal inflammation and protected from renal injury in response to a high salt diet. (A) Representative flow cytometric gating strategy of kidney single-cell suspensions showing the effect of l -NAME followed by high salt exposure on total leukocytes (CD45 + expression), total T lymphocytes (CD3 + ), total CD8 + and CD4 + T cells, CD8 + and CD4 + CD44hi/CD62Llo (TEM cells) and CD44hi/CD62Lhi (TCM cells). SSC-A indicates a side scatter area. (B–E) Summary of flow cytometric quantification of absolute numbers of CD8 + and CD4 + TEM and TCM cells infiltrating the kidney in WT mice that received L-NAME + HS1+HS2±fingolimod. N = 9–16 mice/group. Normally distributed data are expressed as mean ± SEM (panels B, C and D); not normally distributed data are expressed as median ± IQR (panel E) (Supplementary table 1). p -values calculated by unpaired t -test were shown. ** p
    Figure Legend Snippet: S1PR1 pharmacological blockade, via fingolimod, inhibited renal inflammation and protected from renal injury in response to a high salt diet. (A) Representative flow cytometric gating strategy of kidney single-cell suspensions showing the effect of l -NAME followed by high salt exposure on total leukocytes (CD45 + expression), total T lymphocytes (CD3 + ), total CD8 + and CD4 + T cells, CD8 + and CD4 + CD44hi/CD62Llo (TEM cells) and CD44hi/CD62Lhi (TCM cells). SSC-A indicates a side scatter area. (B–E) Summary of flow cytometric quantification of absolute numbers of CD8 + and CD4 + TEM and TCM cells infiltrating the kidney in WT mice that received L-NAME + HS1+HS2±fingolimod. N = 9–16 mice/group. Normally distributed data are expressed as mean ± SEM (panels B, C and D); not normally distributed data are expressed as median ± IQR (panel E) (Supplementary table 1). p -values calculated by unpaired t -test were shown. ** p

    Techniques Used: Expressing, Transmission Electron Microscopy, Mouse Assay

    Fingolimod protects the mice from developing hypertension after exposure to the same hypertensive stimulus (high salt diet). (A) Experimental paradigm: summary of the protocol followed describing the diet fed to the mice at each phase during the experiment. (B) Systolic blood pressure of conscious mice that received L-NAME + HS1+HS2±fingolimod was measured using the non-invasive tail-cuff method. (C) Systolic blood pressure of conscious mice that received L-NAME + HS1+HS2±fingolimod was measured using the invasive radiotelemetry method. N = 6–10 mice/group. Results are presented as mean ± SEM. p -value calculated by 2-way Anova test. * p
    Figure Legend Snippet: Fingolimod protects the mice from developing hypertension after exposure to the same hypertensive stimulus (high salt diet). (A) Experimental paradigm: summary of the protocol followed describing the diet fed to the mice at each phase during the experiment. (B) Systolic blood pressure of conscious mice that received L-NAME + HS1+HS2±fingolimod was measured using the non-invasive tail-cuff method. (C) Systolic blood pressure of conscious mice that received L-NAME + HS1+HS2±fingolimod was measured using the invasive radiotelemetry method. N = 6–10 mice/group. Results are presented as mean ± SEM. p -value calculated by 2-way Anova test. * p

    Techniques Used: Mouse Assay

    Fingolimod protects renal tissue from injury in mice following L-NAME + HS1+HS2±fingolimod protocol. (A) Immunohistochemical analysis of CD3 + T-cells expression in mice kidney tissue after receiving L-NAME + HS1+HS2±fingolimod. (B) Dot plot showing the percentage of CD3 + area in the renal tissue of the mice following L-NAME + HS1+HS2±fingolimod protocol. N = 5 mice/group. (C) Fold change of expression of NGAL relative to GAPDH in the kidney of mice that received L-NAME + HS1+HS2±fingolimod. N = 6 mice/group. Data are expressed as mean ± SEM. p -values calculated by unpaired t -test were shown. ** p
    Figure Legend Snippet: Fingolimod protects renal tissue from injury in mice following L-NAME + HS1+HS2±fingolimod protocol. (A) Immunohistochemical analysis of CD3 + T-cells expression in mice kidney tissue after receiving L-NAME + HS1+HS2±fingolimod. (B) Dot plot showing the percentage of CD3 + area in the renal tissue of the mice following L-NAME + HS1+HS2±fingolimod protocol. N = 5 mice/group. (C) Fold change of expression of NGAL relative to GAPDH in the kidney of mice that received L-NAME + HS1+HS2±fingolimod. N = 6 mice/group. Data are expressed as mean ± SEM. p -values calculated by unpaired t -test were shown. ** p

    Techniques Used: Mouse Assay, Immunohistochemistry, Expressing

    Fingolimod locks CD8 + and CD4 + TEM and TCM cells in the bone marrow and attenuates their secretion of inflammatory cytokines. (A–D) Flow cytometric quantification of total CD8 + (A B) and CD4 + (C D) TEM and TCMsinglengel-cell suspensions of the bone marrow from WT mice following the L-NAME + HS1+HS2±fingolimod protocol. N = 8–20 mice/group. Normally distributed data are expressed as mean ± SEM (panel A D); not normally distributed data are expressed as median ± IQR (panel B C) ( Supplementary Table S2 ). (E–H) Intracellular staining showing the levels of secreted IL-17 and IFN-γ by CD4 + and CD8 + effector memory cells isolated from mice that received L-NAME + HS1+HS2±fingolimod. N = 5 mice/group. All data are normally distributed expressed as mean ± SEM ( Supplementary Table S3 ). p -values calculated by unpaired t -test were shown. * p
    Figure Legend Snippet: Fingolimod locks CD8 + and CD4 + TEM and TCM cells in the bone marrow and attenuates their secretion of inflammatory cytokines. (A–D) Flow cytometric quantification of total CD8 + (A B) and CD4 + (C D) TEM and TCMsinglengel-cell suspensions of the bone marrow from WT mice following the L-NAME + HS1+HS2±fingolimod protocol. N = 8–20 mice/group. Normally distributed data are expressed as mean ± SEM (panel A D); not normally distributed data are expressed as median ± IQR (panel B C) ( Supplementary Table S2 ). (E–H) Intracellular staining showing the levels of secreted IL-17 and IFN-γ by CD4 + and CD8 + effector memory cells isolated from mice that received L-NAME + HS1+HS2±fingolimod. N = 5 mice/group. All data are normally distributed expressed as mean ± SEM ( Supplementary Table S3 ). p -values calculated by unpaired t -test were shown. * p

    Techniques Used: Transmission Electron Microscopy, Mouse Assay, Staining, Isolation

    Fingolimod inhibits the recirculation and redistribution of T EM cells into the kidney in response to moderate hypertensive stimulation. (A) Experimental paradigm: Summary of the protocol followed to study the effect of fingolimod on the recirculation and redistribution of TEM cells after a moderate hypertensive stimulus. Bone marrow TEM cells from donor CD45.2 WT mice received L-NAME + HS1+HS2±fingolimod were adoptively transferred to recipient CD45.1 mice. Recipient mice were then fed a high salt diet for 3 weeks (N = per group) (B) Tail-cuff systolic blood pressure measurements were recorded throughout the whole protocol starting from the baseline (before adoptive transfer) and reaching the end of the 3 weeks of high salt feeding. (C–F) After a successful AT, the levels of the transferred CD8 + and CD4 + TEM cells were measured in the kidney and bone marrow of the recipient mice following high salt feeding. N = 6–11 mice/group. Data are expressed as mean ± SEM. p -values for the effect of l -NAME/High Salt as calculated by unpaired t -test are shown. * p
    Figure Legend Snippet: Fingolimod inhibits the recirculation and redistribution of T EM cells into the kidney in response to moderate hypertensive stimulation. (A) Experimental paradigm: Summary of the protocol followed to study the effect of fingolimod on the recirculation and redistribution of TEM cells after a moderate hypertensive stimulus. Bone marrow TEM cells from donor CD45.2 WT mice received L-NAME + HS1+HS2±fingolimod were adoptively transferred to recipient CD45.1 mice. Recipient mice were then fed a high salt diet for 3 weeks (N = per group) (B) Tail-cuff systolic blood pressure measurements were recorded throughout the whole protocol starting from the baseline (before adoptive transfer) and reaching the end of the 3 weeks of high salt feeding. (C–F) After a successful AT, the levels of the transferred CD8 + and CD4 + TEM cells were measured in the kidney and bone marrow of the recipient mice following high salt feeding. N = 6–11 mice/group. Data are expressed as mean ± SEM. p -values for the effect of l -NAME/High Salt as calculated by unpaired t -test are shown. * p

    Techniques Used: Transmission Electron Microscopy, Mouse Assay, Adoptive Transfer Assay

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  • 94
    TSE systems implantable telemetry system
    S1PR1 pharmacological blockade, via <t>fingolimod,</t> inhibited renal inflammation and protected from renal injury in response to a high salt diet. (A) Representative flow cytometric gating strategy of kidney single-cell suspensions showing the effect of l -NAME followed by high salt exposure on total leukocytes (CD45 + expression), total T lymphocytes (CD3 + ), total CD8 + and CD4 + T cells, CD8 + and CD4 + CD44hi/CD62Llo (TEM cells) and CD44hi/CD62Lhi (TCM cells). SSC-A indicates a side scatter area. (B–E) Summary of flow cytometric quantification of absolute numbers of CD8 + and CD4 + TEM and TCM cells infiltrating the kidney in WT mice that received L-NAME + HS1+HS2±fingolimod. N = 9–16 mice/group. Normally distributed data are expressed as mean ± SEM (panels B, C and D); not normally distributed data are expressed as median ± IQR (panel E) (Supplementary table 1). p -values calculated by unpaired t -test were shown. ** p
    Implantable Telemetry System, supplied by TSE systems, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/implantable telemetry system/product/TSE systems
    Average 94 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    implantable telemetry system - by Bioz Stars, 2022-11
    94/100 stars
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    S1PR1 pharmacological blockade, via fingolimod, inhibited renal inflammation and protected from renal injury in response to a high salt diet. (A) Representative flow cytometric gating strategy of kidney single-cell suspensions showing the effect of l -NAME followed by high salt exposure on total leukocytes (CD45 + expression), total T lymphocytes (CD3 + ), total CD8 + and CD4 + T cells, CD8 + and CD4 + CD44hi/CD62Llo (TEM cells) and CD44hi/CD62Lhi (TCM cells). SSC-A indicates a side scatter area. (B–E) Summary of flow cytometric quantification of absolute numbers of CD8 + and CD4 + TEM and TCM cells infiltrating the kidney in WT mice that received L-NAME + HS1+HS2±fingolimod. N = 9–16 mice/group. Normally distributed data are expressed as mean ± SEM (panels B, C and D); not normally distributed data are expressed as median ± IQR (panel E) (Supplementary table 1). p -values calculated by unpaired t -test were shown. ** p

    Journal: Frontiers in Physiology

    Article Title: Sphingosine 1 phosphate promotes hypertension specific memory T cell trafficking in response to repeated hypertensive challenges

    doi: 10.3389/fphys.2022.930487

    Figure Lengend Snippet: S1PR1 pharmacological blockade, via fingolimod, inhibited renal inflammation and protected from renal injury in response to a high salt diet. (A) Representative flow cytometric gating strategy of kidney single-cell suspensions showing the effect of l -NAME followed by high salt exposure on total leukocytes (CD45 + expression), total T lymphocytes (CD3 + ), total CD8 + and CD4 + T cells, CD8 + and CD4 + CD44hi/CD62Llo (TEM cells) and CD44hi/CD62Lhi (TCM cells). SSC-A indicates a side scatter area. (B–E) Summary of flow cytometric quantification of absolute numbers of CD8 + and CD4 + TEM and TCM cells infiltrating the kidney in WT mice that received L-NAME + HS1+HS2±fingolimod. N = 9–16 mice/group. Normally distributed data are expressed as mean ± SEM (panels B, C and D); not normally distributed data are expressed as median ± IQR (panel E) (Supplementary table 1). p -values calculated by unpaired t -test were shown. ** p

    Article Snippet: Thus, and to preserve the battery, telemetric blood pressure measurements were recorded at the end of the HS2 throughout the treatment of fingolimod (Stellar Telemetry, TSE Systems, United States) as described previously ( ).

    Techniques: Expressing, Transmission Electron Microscopy, Mouse Assay

    Fingolimod protects the mice from developing hypertension after exposure to the same hypertensive stimulus (high salt diet). (A) Experimental paradigm: summary of the protocol followed describing the diet fed to the mice at each phase during the experiment. (B) Systolic blood pressure of conscious mice that received L-NAME + HS1+HS2±fingolimod was measured using the non-invasive tail-cuff method. (C) Systolic blood pressure of conscious mice that received L-NAME + HS1+HS2±fingolimod was measured using the invasive radiotelemetry method. N = 6–10 mice/group. Results are presented as mean ± SEM. p -value calculated by 2-way Anova test. * p

    Journal: Frontiers in Physiology

    Article Title: Sphingosine 1 phosphate promotes hypertension specific memory T cell trafficking in response to repeated hypertensive challenges

    doi: 10.3389/fphys.2022.930487

    Figure Lengend Snippet: Fingolimod protects the mice from developing hypertension after exposure to the same hypertensive stimulus (high salt diet). (A) Experimental paradigm: summary of the protocol followed describing the diet fed to the mice at each phase during the experiment. (B) Systolic blood pressure of conscious mice that received L-NAME + HS1+HS2±fingolimod was measured using the non-invasive tail-cuff method. (C) Systolic blood pressure of conscious mice that received L-NAME + HS1+HS2±fingolimod was measured using the invasive radiotelemetry method. N = 6–10 mice/group. Results are presented as mean ± SEM. p -value calculated by 2-way Anova test. * p

    Article Snippet: Thus, and to preserve the battery, telemetric blood pressure measurements were recorded at the end of the HS2 throughout the treatment of fingolimod (Stellar Telemetry, TSE Systems, United States) as described previously ( ).

    Techniques: Mouse Assay

    Fingolimod protects renal tissue from injury in mice following L-NAME + HS1+HS2±fingolimod protocol. (A) Immunohistochemical analysis of CD3 + T-cells expression in mice kidney tissue after receiving L-NAME + HS1+HS2±fingolimod. (B) Dot plot showing the percentage of CD3 + area in the renal tissue of the mice following L-NAME + HS1+HS2±fingolimod protocol. N = 5 mice/group. (C) Fold change of expression of NGAL relative to GAPDH in the kidney of mice that received L-NAME + HS1+HS2±fingolimod. N = 6 mice/group. Data are expressed as mean ± SEM. p -values calculated by unpaired t -test were shown. ** p

    Journal: Frontiers in Physiology

    Article Title: Sphingosine 1 phosphate promotes hypertension specific memory T cell trafficking in response to repeated hypertensive challenges

    doi: 10.3389/fphys.2022.930487

    Figure Lengend Snippet: Fingolimod protects renal tissue from injury in mice following L-NAME + HS1+HS2±fingolimod protocol. (A) Immunohistochemical analysis of CD3 + T-cells expression in mice kidney tissue after receiving L-NAME + HS1+HS2±fingolimod. (B) Dot plot showing the percentage of CD3 + area in the renal tissue of the mice following L-NAME + HS1+HS2±fingolimod protocol. N = 5 mice/group. (C) Fold change of expression of NGAL relative to GAPDH in the kidney of mice that received L-NAME + HS1+HS2±fingolimod. N = 6 mice/group. Data are expressed as mean ± SEM. p -values calculated by unpaired t -test were shown. ** p

    Article Snippet: Thus, and to preserve the battery, telemetric blood pressure measurements were recorded at the end of the HS2 throughout the treatment of fingolimod (Stellar Telemetry, TSE Systems, United States) as described previously ( ).

    Techniques: Mouse Assay, Immunohistochemistry, Expressing

    Fingolimod locks CD8 + and CD4 + TEM and TCM cells in the bone marrow and attenuates their secretion of inflammatory cytokines. (A–D) Flow cytometric quantification of total CD8 + (A B) and CD4 + (C D) TEM and TCMsinglengel-cell suspensions of the bone marrow from WT mice following the L-NAME + HS1+HS2±fingolimod protocol. N = 8–20 mice/group. Normally distributed data are expressed as mean ± SEM (panel A D); not normally distributed data are expressed as median ± IQR (panel B C) ( Supplementary Table S2 ). (E–H) Intracellular staining showing the levels of secreted IL-17 and IFN-γ by CD4 + and CD8 + effector memory cells isolated from mice that received L-NAME + HS1+HS2±fingolimod. N = 5 mice/group. All data are normally distributed expressed as mean ± SEM ( Supplementary Table S3 ). p -values calculated by unpaired t -test were shown. * p

    Journal: Frontiers in Physiology

    Article Title: Sphingosine 1 phosphate promotes hypertension specific memory T cell trafficking in response to repeated hypertensive challenges

    doi: 10.3389/fphys.2022.930487

    Figure Lengend Snippet: Fingolimod locks CD8 + and CD4 + TEM and TCM cells in the bone marrow and attenuates their secretion of inflammatory cytokines. (A–D) Flow cytometric quantification of total CD8 + (A B) and CD4 + (C D) TEM and TCMsinglengel-cell suspensions of the bone marrow from WT mice following the L-NAME + HS1+HS2±fingolimod protocol. N = 8–20 mice/group. Normally distributed data are expressed as mean ± SEM (panel A D); not normally distributed data are expressed as median ± IQR (panel B C) ( Supplementary Table S2 ). (E–H) Intracellular staining showing the levels of secreted IL-17 and IFN-γ by CD4 + and CD8 + effector memory cells isolated from mice that received L-NAME + HS1+HS2±fingolimod. N = 5 mice/group. All data are normally distributed expressed as mean ± SEM ( Supplementary Table S3 ). p -values calculated by unpaired t -test were shown. * p

    Article Snippet: Thus, and to preserve the battery, telemetric blood pressure measurements were recorded at the end of the HS2 throughout the treatment of fingolimod (Stellar Telemetry, TSE Systems, United States) as described previously ( ).

    Techniques: Transmission Electron Microscopy, Mouse Assay, Staining, Isolation

    Fingolimod inhibits the recirculation and redistribution of T EM cells into the kidney in response to moderate hypertensive stimulation. (A) Experimental paradigm: Summary of the protocol followed to study the effect of fingolimod on the recirculation and redistribution of TEM cells after a moderate hypertensive stimulus. Bone marrow TEM cells from donor CD45.2 WT mice received L-NAME + HS1+HS2±fingolimod were adoptively transferred to recipient CD45.1 mice. Recipient mice were then fed a high salt diet for 3 weeks (N = per group) (B) Tail-cuff systolic blood pressure measurements were recorded throughout the whole protocol starting from the baseline (before adoptive transfer) and reaching the end of the 3 weeks of high salt feeding. (C–F) After a successful AT, the levels of the transferred CD8 + and CD4 + TEM cells were measured in the kidney and bone marrow of the recipient mice following high salt feeding. N = 6–11 mice/group. Data are expressed as mean ± SEM. p -values for the effect of l -NAME/High Salt as calculated by unpaired t -test are shown. * p

    Journal: Frontiers in Physiology

    Article Title: Sphingosine 1 phosphate promotes hypertension specific memory T cell trafficking in response to repeated hypertensive challenges

    doi: 10.3389/fphys.2022.930487

    Figure Lengend Snippet: Fingolimod inhibits the recirculation and redistribution of T EM cells into the kidney in response to moderate hypertensive stimulation. (A) Experimental paradigm: Summary of the protocol followed to study the effect of fingolimod on the recirculation and redistribution of TEM cells after a moderate hypertensive stimulus. Bone marrow TEM cells from donor CD45.2 WT mice received L-NAME + HS1+HS2±fingolimod were adoptively transferred to recipient CD45.1 mice. Recipient mice were then fed a high salt diet for 3 weeks (N = per group) (B) Tail-cuff systolic blood pressure measurements were recorded throughout the whole protocol starting from the baseline (before adoptive transfer) and reaching the end of the 3 weeks of high salt feeding. (C–F) After a successful AT, the levels of the transferred CD8 + and CD4 + TEM cells were measured in the kidney and bone marrow of the recipient mice following high salt feeding. N = 6–11 mice/group. Data are expressed as mean ± SEM. p -values for the effect of l -NAME/High Salt as calculated by unpaired t -test are shown. * p

    Article Snippet: Thus, and to preserve the battery, telemetric blood pressure measurements were recorded at the end of the HS2 throughout the treatment of fingolimod (Stellar Telemetry, TSE Systems, United States) as described previously ( ).

    Techniques: Transmission Electron Microscopy, Mouse Assay, Adoptive Transfer Assay