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Qualitative analysis of randomized controlled trials

Journal: Sports Medicine (Auckland, N.z.)

Article Title: Effects of Exercise on DNA Methylation: A Systematic Review of Randomized Controlled Trials

doi: 10.1007/s40279-024-02033-0

Figure Lengend Snippet: Qualitative analysis of randomized controlled trials

Article Snippet: Gillman et al. [ ] , 2021 , 135 women aged 30–45 years (33 EG1, 31 EG2, 41 EG3 and 32 EG4) , 16 weeks of supervised aerobic exercise 4 times/week EG1: 40 min high intensity EG2: 20 min high intensity EG3: 40 min moderate intensity EG4: 20 min moderate intensity , Peripheral blood , Pyrosequencing , BRCA1, RUNX3, SIM1, AURKA, BCAR1, BPIFA4P, GALNT9, FBLN2, PAX6, TLR4 and TLR6 , DNA methylation was significantly increased in EG compared to CG at the following genes: AURKA: p = 0.04 BCAR1: p = 0.06 BPIFA4P: p = 0.005 BRCA1: p = 0.04 No significant between-group differences were found in SIM1, FBLN2, GALNT9, PAX6, RUNX3, TLR4 and TLR6.

Techniques: Methylation, DNA Methylation Assay, Real-time Polymerase Chain Reaction, Amplification, Enzyme-linked Immunosorbent Assay, Genome Wide