sirt3 54905 antibodies  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc sirt3 54905 antibodies
    Sirt3 54905 Antibodies, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt3 54905 antibodies/product/Cell Signaling Technology Inc
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sirt3 54905 antibodies - by Bioz Stars, 2023-01
    92/100 stars

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    sirt3 54905 antibodies  (Cell Signaling Technology Inc)


    Bioz Verified Symbol Cell Signaling Technology Inc is a verified supplier
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    Cell Signaling Technology Inc sirt3 54905 antibodies
    Sirt3 54905 Antibodies, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt3 54905 antibodies/product/Cell Signaling Technology Inc
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sirt3 54905 antibodies - by Bioz Stars, 2023-01
    92/100 stars

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    sirt3  (Cell Signaling Technology Inc)


    Bioz Verified Symbol Cell Signaling Technology Inc is a verified supplier
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    Cell Signaling Technology Inc sirt3
    Sirt3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt3/product/Cell Signaling Technology Inc
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sirt3 - by Bioz Stars, 2023-01
    92/100 stars

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    sirt3  (Cell Signaling Technology Inc)


    Bioz Verified Symbol Cell Signaling Technology Inc is a verified supplier
    Bioz Manufacturer Symbol Cell Signaling Technology Inc manufactures this product  
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    Cell Signaling Technology Inc sirt3
    (A) Systolic blood pressure was measured by telemetry before and after Ang II-infusion (0.7 mg/kg/day). Data were analyzed using 2-way ANOVA with repeated measurements. *P=0.02, n=8 in each group. Insert shows representative Western blot of <t>Sirt3</t> aortas isolated from Sirt3OX mice and wild-type C57Bl/6J littermates. (B) Endothelial-dependent relaxation to acetylcholine. Vasculare relaxation data were analyzed using 2-way ANOVA with repeated measurements. *P=0.01 Sirt3OX+Ang II vs WT+Ang II, n=8 in each group. (C) Aortic superoxide (O2•) was measured by DHE-HPLC assay of O2• specific product, 2-hydroxyethidium (2-OH-E+).12 (D) Endothelial nitric oxide (NO) measured by NO spin trap FeDETC2 and Electron Paramagnetic Resonance (EPR).12 For (C) and (D), data were analyzed using 2-way ANOVA and Bonferroni post-hoc multiple comparisons. Results are mean ± SEM (n=5). *P<0.01 vs WT, **P<0.01 Sirt3OX+Ang II vs WT+Ang II.
    Sirt3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt3/product/Cell Signaling Technology Inc
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sirt3 - by Bioz Stars, 2023-01
    92/100 stars

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    1) Product Images from "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress"

    Article Title: Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

    Journal: Circulation research

    doi: 10.1161/CIRCRESAHA.119.315767

    (A) Systolic blood pressure was measured by telemetry before and after Ang II-infusion (0.7 mg/kg/day). Data were analyzed using 2-way ANOVA with repeated measurements. *P=0.02, n=8 in each group. Insert shows representative Western blot of Sirt3 aortas isolated from Sirt3OX mice and wild-type C57Bl/6J littermates. (B) Endothelial-dependent relaxation to acetylcholine. Vasculare relaxation data were analyzed using 2-way ANOVA with repeated measurements. *P=0.01 Sirt3OX+Ang II vs WT+Ang II, n=8 in each group. (C) Aortic superoxide (O2•) was measured by DHE-HPLC assay of O2• specific product, 2-hydroxyethidium (2-OH-E+).12 (D) Endothelial nitric oxide (NO) measured by NO spin trap FeDETC2 and Electron Paramagnetic Resonance (EPR).12 For (C) and (D), data were analyzed using 2-way ANOVA and Bonferroni post-hoc multiple comparisons. Results are mean ± SEM (n=5). *P<0.01 vs WT, **P<0.01 Sirt3OX+Ang II vs WT+Ang II.
    Figure Legend Snippet: (A) Systolic blood pressure was measured by telemetry before and after Ang II-infusion (0.7 mg/kg/day). Data were analyzed using 2-way ANOVA with repeated measurements. *P=0.02, n=8 in each group. Insert shows representative Western blot of Sirt3 aortas isolated from Sirt3OX mice and wild-type C57Bl/6J littermates. (B) Endothelial-dependent relaxation to acetylcholine. Vasculare relaxation data were analyzed using 2-way ANOVA with repeated measurements. *P=0.01 Sirt3OX+Ang II vs WT+Ang II, n=8 in each group. (C) Aortic superoxide (O2•) was measured by DHE-HPLC assay of O2• specific product, 2-hydroxyethidium (2-OH-E+).12 (D) Endothelial nitric oxide (NO) measured by NO spin trap FeDETC2 and Electron Paramagnetic Resonance (EPR).12 For (C) and (D), data were analyzed using 2-way ANOVA and Bonferroni post-hoc multiple comparisons. Results are mean ± SEM (n=5). *P<0.01 vs WT, **P<0.01 Sirt3OX+Ang II vs WT+Ang II.

    Techniques Used: Western Blot, Isolation, Electron Paramagnetic Resonance

    Representative images of hematoxylin and eosin-stained aortic cross sections are shown. Aortic thickness (A) and medial area (B) were quantified as described previously.32 Supplemental Online Figure I displays typical low magnification images with the intact vascular lumen to show the range of vessel wall thickness. Aortic hypertrophy was increased in Sirt3−/− mice, and Sirt3 overexpression reduced vascular hypertrophy in Sirt3OX mice compared to wild-type littermates. Data were analyzed using 2-way ANOVA and Bonferroni post-hoc multiple comparisons. Values are mean ± SEM. (A) *P=0.007 Sirt3−/− Sham vs WT sham, *P=0.00006 WT+Ang II vs WT sham, +P=0.003 vs WT sham, **P=0.0035 vs WT+Ang II, #P=0.0038 vs WT+Ang II (n=5). (B) *P=0.0012 Sirt3−/− Sham vs WT sham, *P=0.00005 WT+Ang II vs WT sham, +P=0.04 vs WT sham, **P=0.001 vs WT+Ang II, #P=0.0007 vs WT+Ang II (n=5).
    Figure Legend Snippet: Representative images of hematoxylin and eosin-stained aortic cross sections are shown. Aortic thickness (A) and medial area (B) were quantified as described previously.32 Supplemental Online Figure I displays typical low magnification images with the intact vascular lumen to show the range of vessel wall thickness. Aortic hypertrophy was increased in Sirt3−/− mice, and Sirt3 overexpression reduced vascular hypertrophy in Sirt3OX mice compared to wild-type littermates. Data were analyzed using 2-way ANOVA and Bonferroni post-hoc multiple comparisons. Values are mean ± SEM. (A) *P=0.007 Sirt3−/− Sham vs WT sham, *P=0.00006 WT+Ang II vs WT sham, +P=0.003 vs WT sham, **P=0.0035 vs WT+Ang II, #P=0.0038 vs WT+Ang II (n=5). (B) *P=0.0012 Sirt3−/− Sham vs WT sham, *P=0.00005 WT+Ang II vs WT sham, +P=0.04 vs WT sham, **P=0.001 vs WT+Ang II, #P=0.0007 vs WT+Ang II (n=5).

    Techniques Used: Staining, Over Expression

    (A) Typical Western blots of caspase 1, p65, VCAM, ICAM and MCP1 normalized for GAPDH in aortas. (B) caspase 1, (C) p65 (NFkB subunit) and (D) VCAM levels normalized by GAPDH compared to Sham wild-type mice (100%). Results are mean ± SEM (n=6). *P<0.05 vs WT Sham, **P<0.01 vs WT+Ang II, #P<0.01 vs WT Sham. (E) Accumulation of T cells and macrophages in kidneys of six month old Sirt3−/−, Sirt3OX and wild-type mice measured by flow cytometry as described previously.53 Online Figure II shows the representative images of flow cytometry and gating strategy. Results are mean ± SEM (n=4). Data were analyzed using 2-way ANOVA and Bonferroni post-hoc multiple comparisons. *P<0.01 vs WT, **P<0.05 vs WT.
    Figure Legend Snippet: (A) Typical Western blots of caspase 1, p65, VCAM, ICAM and MCP1 normalized for GAPDH in aortas. (B) caspase 1, (C) p65 (NFkB subunit) and (D) VCAM levels normalized by GAPDH compared to Sham wild-type mice (100%). Results are mean ± SEM (n=6). *P<0.05 vs WT Sham, **P<0.01 vs WT+Ang II, #P<0.01 vs WT Sham. (E) Accumulation of T cells and macrophages in kidneys of six month old Sirt3−/−, Sirt3OX and wild-type mice measured by flow cytometry as described previously.53 Online Figure II shows the representative images of flow cytometry and gating strategy. Results are mean ± SEM (n=4). Data were analyzed using 2-way ANOVA and Bonferroni post-hoc multiple comparisons. *P<0.01 vs WT, **P<0.05 vs WT.

    Techniques Used: Western Blot, Flow Cytometry

    (A) Typical Western blots of aortic TERT, p21, and SA-β-gal in 6-month-old wild-type, Sirt3−/− and Sirt3OX mice. (B) TERT and (C) p21 levels normalized by GAPDH compared to Sham wild-type mice (100%). Results are mean ± SEM (n=5). Data were analyzed using 1-way ANOVA and Bonferroni post-hoc multiple comparisons. *P<0.01 vs WT, **P<0.01 vs WT. (D) Systolic blood pressure in Sirt3−/− and WT mice. Data were analyzed with 2-way ANOVA with repeated measurements. *P=0.008 vs WT (n=6).
    Figure Legend Snippet: (A) Typical Western blots of aortic TERT, p21, and SA-β-gal in 6-month-old wild-type, Sirt3−/− and Sirt3OX mice. (B) TERT and (C) p21 levels normalized by GAPDH compared to Sham wild-type mice (100%). Results are mean ± SEM (n=5). Data were analyzed using 1-way ANOVA and Bonferroni post-hoc multiple comparisons. *P<0.01 vs WT, **P<0.01 vs WT. (D) Systolic blood pressure in Sirt3−/− and WT mice. Data were analyzed with 2-way ANOVA with repeated measurements. *P=0.008 vs WT (n=6).

    Techniques Used: Western Blot

    sirt3  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc sirt3
    Sirt3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt3/product/Cell Signaling Technology Inc
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sirt3 - by Bioz Stars, 2023-01
    92/100 stars

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    Cell Signaling Technology Inc sirt3 54905 antibodies
    Sirt3 54905 Antibodies, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt3 54905 antibodies/product/Cell Signaling Technology Inc
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sirt3 54905 antibodies - by Bioz Stars, 2023-01
    92/100 stars
    		  Buy from Supplier
    sirt3  (Cell Signaling Technology Inc)
    92
    Cell Signaling Technology Inc sirt3
    Sirt3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt3/product/Cell Signaling Technology Inc
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    sirt3 - by Bioz Stars, 2023-01
    92/100 stars
    		  Buy from Supplier

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