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Journal: bioRxiv
Article Title: Cell-Type-Specific Bidirectional Modulation of the Cortico–Thalamo–Cortical Sensory Pathway by Transcranial Focused Ultrasound (tFUS)
doi: 10.64898/2026.03.23.713540
Figure Lengend Snippet: Experimental setup and ultrasound parameter. (A) Experimental setup of intracranial electrodes for recording multi-region signals, optical fiber for activating specific type of neurons and 128-element random array ultrasound transducer. The 64-channel optrode was inserted into left somatosensory cortex (S1) and 32-channel electrode was inserted into left posteromedial of the thalamus (POm). Vibration-tactile stimulation was applied to the right hind paw. (B) Ultrasound parameters used in this study. The inter-sonication interval (ISI) was set at 2.5s with 10% jitter to avoid neuronal adaptation to fixed ISI. Ultrasound duration (UD) was set at 100ms with vibration stimulation or 67ms for tFUS only. Pulse repetitive frequencies (PRFs) and duty cycles (DCs) tested in this study were 30Hz with 0.6%DC and 3000Hz with 60% DC. Pulse durations (PD) were calculated by PRF*DCs. (C-D) Ex-vivo hydrophone peak-to-peak pressure amplitude z-axis (upper) and y-axis (bottom) scan at the estimated targeted brain region with low pressure (C, ∼98kPa) and high pressure (D, ∼163kPa).
Article Snippet: A
Techniques: Sonication, Ex Vivo