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tnf α 50 nmol l jnk inhibitor sp600125  (Tocris)


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    Tocris tnf α 50 nmol l jnk inhibitor sp600125
    ( A ) Kymographs of LysoTracker-labeled organelles in axons from dorsal root ganglia (DRG) neurons with 1.0 U/mL insulin. The horizontal and vertical arrows indicate retrograde direction and recording time (4 minutes), respectively. ( B – E ) The percentage of organelles in 100 μm axon segments that moved anterogradely ( B ), retrogradely ( C ), bidirectionally ( D ), or were stationary ( E ). n = 18–21 axons from 3 independent experiments. ( F ) The velocity of retrograde movements (RV) in 100 μm axon segments. The data consisted of 200–300 movements. ( G ) Kymographs in axons from DRG neurons treated with vehicle and insulin receptor antagonist (BMS-754807, 300 or 500 nmol/L). The stimulation time was 60 minutes. The horizontal and vertical arrows indicate retrograde direction and recording time (4 minutes), respectively. ( H – K ) The percentage of organelles in 100 μm axon segments that moved anterogradely ( H ), retrogradely ( I ), or bidirectionally ( J ), or were stationary ( K ). n = 18–21 axons from 3 independent experiments. ( L ) RV in 100 μm axon segments in each treatment condition. ( M ) Kymographs in axons from DRG neurons treated with vehicle, TNF-α, and TNF-α + JNK inhibitor <t>(SP600125).</t> The stimulation time was 20 minutes. The vertical arrow indicates recording time (4 minutes). ( N – Q ) The percentage of organelles in 100 μm axon segments that moved anterogradely ( N ), retrogradely ( O ), bidirectionally ( P ), or were stationary ( Q ). n = 18–21 axons from 3 independent experiments. ( R ) RV in 100 μm axon segments. The data consisted of 200–300 movements. The data are presented as the mean ± SD. Because the experiments of G – L and M – R were performed contemporaneously, statistical analysis was done using same vehicle control. Statistical analysis was performed by Student’s 2-tailed unpaired t test for B – F and by 1-way ANOVA with Tukey’s multiple-comparison test for H – L and N – R . ** P < 0.01, *** P < 0.001.
    Tnf α 50 Nmol L Jnk Inhibitor Sp600125, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 682 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nmol+l+tumor+necrosis+factor/pmc09746912-271-56-64?v=Tocris
    Average 95 stars, based on 682 article reviews
    tnf α 50 nmol l jnk inhibitor sp600125 - by Bioz Stars, 2026-08
    95/100 stars

    Images

    1) Product Images from "RAGE activation in macrophages and development of experimental diabetic polyneuropathy"

    Article Title: RAGE activation in macrophages and development of experimental diabetic polyneuropathy

    Journal: JCI Insight

    doi: 10.1172/jci.insight.160555

    ( A ) Kymographs of LysoTracker-labeled organelles in axons from dorsal root ganglia (DRG) neurons with 1.0 U/mL insulin. The horizontal and vertical arrows indicate retrograde direction and recording time (4 minutes), respectively. ( B – E ) The percentage of organelles in 100 μm axon segments that moved anterogradely ( B ), retrogradely ( C ), bidirectionally ( D ), or were stationary ( E ). n = 18–21 axons from 3 independent experiments. ( F ) The velocity of retrograde movements (RV) in 100 μm axon segments. The data consisted of 200–300 movements. ( G ) Kymographs in axons from DRG neurons treated with vehicle and insulin receptor antagonist (BMS-754807, 300 or 500 nmol/L). The stimulation time was 60 minutes. The horizontal and vertical arrows indicate retrograde direction and recording time (4 minutes), respectively. ( H – K ) The percentage of organelles in 100 μm axon segments that moved anterogradely ( H ), retrogradely ( I ), or bidirectionally ( J ), or were stationary ( K ). n = 18–21 axons from 3 independent experiments. ( L ) RV in 100 μm axon segments in each treatment condition. ( M ) Kymographs in axons from DRG neurons treated with vehicle, TNF-α, and TNF-α + JNK inhibitor (SP600125). The stimulation time was 20 minutes. The vertical arrow indicates recording time (4 minutes). ( N – Q ) The percentage of organelles in 100 μm axon segments that moved anterogradely ( N ), retrogradely ( O ), bidirectionally ( P ), or were stationary ( Q ). n = 18–21 axons from 3 independent experiments. ( R ) RV in 100 μm axon segments. The data consisted of 200–300 movements. The data are presented as the mean ± SD. Because the experiments of G – L and M – R were performed contemporaneously, statistical analysis was done using same vehicle control. Statistical analysis was performed by Student’s 2-tailed unpaired t test for B – F and by 1-way ANOVA with Tukey’s multiple-comparison test for H – L and N – R . ** P < 0.01, *** P < 0.001.
    Figure Legend Snippet: ( A ) Kymographs of LysoTracker-labeled organelles in axons from dorsal root ganglia (DRG) neurons with 1.0 U/mL insulin. The horizontal and vertical arrows indicate retrograde direction and recording time (4 minutes), respectively. ( B – E ) The percentage of organelles in 100 μm axon segments that moved anterogradely ( B ), retrogradely ( C ), bidirectionally ( D ), or were stationary ( E ). n = 18–21 axons from 3 independent experiments. ( F ) The velocity of retrograde movements (RV) in 100 μm axon segments. The data consisted of 200–300 movements. ( G ) Kymographs in axons from DRG neurons treated with vehicle and insulin receptor antagonist (BMS-754807, 300 or 500 nmol/L). The stimulation time was 60 minutes. The horizontal and vertical arrows indicate retrograde direction and recording time (4 minutes), respectively. ( H – K ) The percentage of organelles in 100 μm axon segments that moved anterogradely ( H ), retrogradely ( I ), or bidirectionally ( J ), or were stationary ( K ). n = 18–21 axons from 3 independent experiments. ( L ) RV in 100 μm axon segments in each treatment condition. ( M ) Kymographs in axons from DRG neurons treated with vehicle, TNF-α, and TNF-α + JNK inhibitor (SP600125). The stimulation time was 20 minutes. The vertical arrow indicates recording time (4 minutes). ( N – Q ) The percentage of organelles in 100 μm axon segments that moved anterogradely ( N ), retrogradely ( O ), bidirectionally ( P ), or were stationary ( Q ). n = 18–21 axons from 3 independent experiments. ( R ) RV in 100 μm axon segments. The data consisted of 200–300 movements. The data are presented as the mean ± SD. Because the experiments of G – L and M – R were performed contemporaneously, statistical analysis was done using same vehicle control. Statistical analysis was performed by Student’s 2-tailed unpaired t test for B – F and by 1-way ANOVA with Tukey’s multiple-comparison test for H – L and N – R . ** P < 0.01, *** P < 0.001.

    Techniques Used: Labeling, Control, Comparison



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