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recombinant α synuclein e46k  (MedChemExpress)


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    Structured Review

    MedChemExpress recombinant α synuclein e46k
    Recombinant α Synuclein E46k, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-p3140a/%CE%B1-Synuclein/10__1016_slash_j__dyepig__2025__113160-150-2-11
    Average 93 stars, based on 1 article reviews
    recombinant α synuclein e46k - by Bioz Stars, 2026-10
    93/100 stars

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    Related Articles

    Activity Assay:

    Article Title: Alpha-Synuclein: The Spark That Flames Dopaminergic Neurons, In Vitro and In Vivo Evidence
    Article Snippet: After 6 days of culture, the dopaminergic neurons were injured with α-syn (250 nmol/L) up to 168 h. Dynasore (Selleckchem, Houston, TX, USA), an inhibitor of clathrin-mediated endocytosis was applied for 2 h, 6 h or 96 h, from day 6 of culture, in presence of α-syn (250 nmol/L). .. Conduritol B epoxide (MedChem Express, Sollentuna, Sweden), an inhibitor of GBA, was applied alone (at 20 µmol/L, inducing around 50% decrease of GBA activity) or combined with α-syn (250 nmol/L), on day 6. ..

    Article Title: Alpha-Synuclein: The Spark That Flames Dopaminergic Neurons, In Vitro and In Vivo Evidence.
    Article Snippet: After 6 days of culture, the dopaminergic neurons were injured with α-syn (250 nmol/L) up to 168 h. Dynasore (Selleckchem, Houston, TX, USA), an inhibitor of clathrin-mediated endocytosis was applied for 2 h, 6 h or 96 h, from day 6 of culture, in presence of α-syn (250 nmol/L). .. Conduritol B epoxide (MedChem Express, Sollentuna, Sweden), an inhibitor of GBA, was applied alone (at 20 μmol/L, inducing around 50% decrease of GBA activity) or combined with α-syn (250 nmol/L), on day 6. ..

    Inhibition:

    Article Title: α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome
    Article Snippet: .. The drug treatment group was treated with 10 μg/ml oligomerized α-synuclein, while the autophagy inhibition group was added with 10 μg/ml oligomerized α-synuclein and 5 mM 3-MA (MCE, hy-19312), and the culture was continued for 24 h. .. RIPA lysate (Beyotime, P0013C) was applied for cell lysis and centrifugation at 15,000 × g for 15 min at 4°C to extract cell protein.

    Article Title: α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
    Article Snippet: .. The drug treatment group was treated with 10 μg/ml oligomerized α-synuclein, while the autophagy inhibition group was added with 10 μg/ml oligomerized α-synuclein and 5 mM 3-MA (MCE, hy-19312), and the culture was continued for 24 h. Western blot for protein detection. .. RIPA lysate (Beyotime, P0013C) was applied for cell lysis and centrifugation at 15,000 x g for 15 min at 4 ̊C to extract cell protein.

    Western Blot:

    Article Title: α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
    Article Snippet: .. The drug treatment group was treated with 10 μg/ml oligomerized α-synuclein, while the autophagy inhibition group was added with 10 μg/ml oligomerized α-synuclein and 5 mM 3-MA (MCE, hy-19312), and the culture was continued for 24 h. Western blot for protein detection. .. RIPA lysate (Beyotime, P0013C) was applied for cell lysis and centrifugation at 15,000 x g for 15 min at 4 ̊C to extract cell protein.

    Recombinant:

    Article Title: Highly selective small molecular fluorescence probes for detecting α-syn fibrils
    Article Snippet: Misfolded α-synuclein (α-Syn) is a major pathological hallmark of Parkinson’s disease (PD), and small-molecule fluorescent probes targeting α-Syn could significantly advance etiology studies, enable early diagnosis, and support therapeutic evaluation.. However, the advancement of selective probes has been hindered by the structural resemblance between α-Syn and β-amyloid (Aβ) fibrils.. Herein, we presented a series of donoracceptor-based fluorescent probes that exhibit remarkable selectivity for α-Syn over Aβ.

    Concentration Assay:

    Article Title: Highly selective small molecular fluorescence probes for detecting α-syn fibrils
    Article Snippet: Misfolded α-synuclein (α-Syn) is a major pathological hallmark of Parkinson’s disease (PD), and small-molecule fluorescent probes targeting α-Syn could significantly advance etiology studies, enable early diagnosis, and support therapeutic evaluation.. However, the advancement of selective probes has been hindered by the structural resemblance between α-Syn and β-amyloid (Aβ) fibrils.. Herein, we presented a series of donoracceptor-based fluorescent probes that exhibit remarkable selectivity for α-Syn over Aβ.



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