tat glua2 3y (MedChemExpress)
MedChemExpress is a verified supplier 
MedChemExpress manufactures this product 
93
Structured Review
MedChemExpress
tat glua2 3y
Tat Glua2 3y, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p2259/TAT-GluA2+3Y/pmc12058529-414-28-33
Average 93 stars, based on 2 article reviews
Tat Glua2 3y, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p2259/TAT-GluA2+3Y/pmc12058529-414-28-33
Average 93 stars, based on 2 article reviews
tat glua2 3y - by Bioz Stars,
2026-10
93/100 stars
Images
1) Product Images from "Stress dynamically modulates neuronal autophagy to gate depression onset"
Article Title: Stress dynamically modulates neuronal autophagy to gate depression onset
Journal: Nature
doi: 10.1038/s41586-025-08807-4
Figure Legend Snippet: STORM showing localization of GluA2 (green) and LC3 puncta (red) in LHb.
Techniques Used:
Figure Legend Snippet: STORM showing localization of GluA2 (green) and LC3 puncta (red) in Arc.
Techniques Used:
Figure Legend Snippet: STORM showing localization of GluA2 (green) and LC3 puncta (red) in BLA.
Techniques Used:
Figure Legend Snippet: a – h , Western blot analysis showing that CRS ( a – d ) increased, whereas activating LHb autophagy by local infusion of tBP ( e – h ) decreased, the expression of GluA1 ( a , e ), GluA2 ( b , f ) and GluN1 ( c , g ), without affecting the GABA A receptor subunit ( d , h ) ( a – c , n naive/CRS = 5 per group; d , n naive/CRS = 4; e – h , n CRS+tBP-scm/CRS+tBP = 4 per group). α-tub, α-tubulin i , Experimental design. j , k , Representative traces ( j ) and quantification ( k ) show the acute effect of tBP perfusion on spontaneous firing patterns and firing frequency of LHb neurons ( n ACSF/0.5/1/5 = 8, 8, 9 neurons, n ACSF/0.5/1/5 = 7, 6, 6 mice). l – p , Representative traces ( l ) and quantification (frequency ( m , o ) and amplitude ( n , p ) of sEPSC and sIPSC) showing spontaneous neural transmission before and right after tBP perfusion in LHb neurons of CRS mice (1 μM tBP, n ACSF/tBP = 8 neurons, n ACSF/tBP = 6 mice). q – u , Representative traces ( q ) and quantification ( r – u ) showing spontaneous neural transmission before and right after coperfusion of tBP and Dyngo-4a in LHb neurons of CRS mice (Dyngo-4a + 1 μM tBP, n ACSF/Dyngo+tBP = 8 neurons, n ACSF/Dyngo+tBP = 3 mice): sEPSC frequency ( r ), sEPSC amplitude ( s ), sIPSC frequency ( t ) and sIPSC amplitude ( u ). v , Bar graph showing spontaneous firing frequency before and after coperfusion of tBP and Dyngo-4a (Dyngo-4a + 1 μM tBP, n ACSF/Dyngo+tBP = 8 neurons, n ACSF/Dyngo+tBP = 3 mice). w , Experimental design. x , y , tBP decreases immobile duration in FST ( x ) and increases sucrose preference in SPT ( y ) whereas co-application of tBP with Dyngo-4a or TAT–GluA2 3Y reverses this effect ( x , n Veh/Dyngo/tBP/tBP+TAT–GluA23y/Dyngo+tBP = 8, 10, 12, 10, 7; y , n Veh/Dyngo/tBP/tBP+TAT–GluA23y/Dyngo+tBP = 9, 10, 10, 11, 8. Two-sided Mann–Whitney test ( a – h ), two-sided paired t -test ( k , m – p , r – v ), two-sided Wilcoxon test ( k ), one-way ANOVA with uncorrected Fisher’s LSD test ( x , y ). Data are mean ± s.e.m. Schematic in w adapted from ref. , Elsevier.
Techniques Used: Western Blot, Expressing, Transmission Assay, MANN-WHITNEY
Figure Legend Snippet: a , Experimental design. b,c , Representative images (left) and quantification (right) of p62 or Beclin-1 western blot showing LTD induction protocol instantly enhances autophagy level in LHb of naïve mice (i.e., decreased p62 and increased Beclin-1 ( b , n mCherry/oChIEF = 3/group for p62, n mCherry/oChIEF = 4/group for Beclin-1) but not CRS mice ( c , n mCherry/oChIEF = 3/group for p62, n mCherry/oChIEF = 4/group for Beclin-1). d , LFS fails to induce LTD in the LHb of CRS mice (n naïve = 9 neurons, 7 mice; n CRS = 11 neurons, 7 mice). e , SBI abolishes the LTD induction and induces a slight but significant LTP in LHb neurons (n = 7 neurons, 6 mice). f , Schematics of stereotaxic surgeries. g , Conditional knock-out of Atg7 abolishes LTD in LHb neurons (n Atg7+/+ = 11 neurons, 6 mice; n Atg7−/− = 10 neurons, 7 mice). h , Kinetics and representative traces showing conditional knock-out of Atg7 increases the LTP magnitude in LHb neurons (n Atg7+/+ = 8 neurons, 3 mice; n Atg7−/− = 10 neurons, 8 mice). i , tBP, but not tBP-scm, directly induces dose-dependent pharmacological LTD in the LHb of CRS mice (1 μΜ tBP, n = 10 neurons, 8 mice; 5 μΜ tBP, n = 11 neurons, 7 mice; 1 μΜ tBP-scm, n = 10 neurons, 7 mice). j , TAT-GluA2 3Y peptide, but not its scrambled analog (TAT-GluA2 3Y -scm), disrupts the tBP-induced LTD in the LHb of CRS mice (TAT-GluA2 3Y , n = 9 neurons, 6 mice; TAT-GluA2 3Y -scm, n = 9 neurons, 7 mice). k , tBP fails to induce LTD in the LHb of Atg7 LHb−/− mice (n = 11 neurons, 7 mice). Two-sided Unpaired t -test for all. Data are mean ± s.e.m. Schematics in a , f adapted from ref. , Elsevier.
Techniques Used: Western Blot, Knock-Out
Related Articles
Sequencing:Article Title: AMPA receptor potentiation alleviates NLRP3 knockout-induced fear generalization in mice. Article Snippet: Genetic knockout and pharmaceutical inhibition of the NLRP3 inflammasome enhances the extinction of contextual fear memory, which is attributed to its role in neuronal and synaptic dysregulation, concurrent with neurotransmitter function disturbances.. This study aimed to determine whether NLRP3 plays a role in generalizing fear via the inflammatory axis.. We established the NLRP3 KO mice model, followed by behavioral and biochemical analyses. |