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hy p2222  (MedChemExpress)


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    MedChemExpress hy p2222

    Hy P2222, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-p2222/DX600/pmc08832557-25-5-2
    Average 90 stars, based on 1 article reviews
    hy p2222 - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry"

    Article Title: Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry

    Journal: Cell Metabolism

    doi: 10.1016/j.cmet.2022.01.008


    Figure Legend Snippet:

    Techniques Used: Recombinant, Enzyme-linked Immunosorbent Assay, RNA Extraction, SYBR Green Assay, Activity Assay, Cholesterol Assay, Software

    Related Articles

    other:

    Article Title:
    Article Snippet: DX600 , MedChenExpress , Cat. HY-P2222.

    Article Title: Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2.
    Article Snippet: The binding assays were conducted in 96-well conical V-bottom plates (Corning, Tewksbury, MA, USA) containing 2 × 105 induced yeast cells per well.

    Inhibition:

    Article Title: AI-guided multi-omics analysis identifies NPC1-modulated susceptibility to SARS-CoV-2 infection under PM 2.5 exposure.
    Article Snippet: .. AR TI CL E IN P RE SS ACE2 inhibition and receptor-blocking assays To inhibit the enzymatic activity of ACE2, cells were treated with 10, 20, and 50 μM DX600 (MCE, USA) at 37 °C for 1 h. ACE2 activity of cell lysates was assessed with the Fluorometric ACE2 Activity Assay Kit (Beyotime, China) according to the manufacturer’s directions. .. Fluorescence kinetics were measured by a VarioskanTM Flash multimode reader (Thermo Fisher Scientific, USA) at an excitation wavelength of 325 nm and an emission wavelength of 393 nm.

    Activity Assay:

    Article Title: AI-guided multi-omics analysis identifies NPC1-modulated susceptibility to SARS-CoV-2 infection under PM 2.5 exposure.
    Article Snippet: .. AR TI CL E IN P RE SS ACE2 inhibition and receptor-blocking assays To inhibit the enzymatic activity of ACE2, cells were treated with 10, 20, and 50 μM DX600 (MCE, USA) at 37 °C for 1 h. ACE2 activity of cell lysates was assessed with the Fluorometric ACE2 Activity Assay Kit (Beyotime, China) according to the manufacturer’s directions. .. Fluorescence kinetics were measured by a VarioskanTM Flash multimode reader (Thermo Fisher Scientific, USA) at an excitation wavelength of 325 nm and an emission wavelength of 393 nm.

    Virus:

    Article Title: Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry
    Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Rabbit monoclonal anti-FoxO1 Cell Signaling Technology Cat. #2880; RRID: AB_2106495 Rabbit polyclonal anti-ACE2 Abcam Cat. ab15348; RRID: AB_301861 Rabbit monoclonal anti-b-Actin Cell Signaling Technology Cat. #4970; RRID: AB_2223172 Rabbit monoclonal anti-SARS-CoV-2 Nucleocapsid Sino Biological Company Cat. # 40143-R001; RRID: AB_2827974 Rabbit monoclonal anti-HA Cell Signaling Technology Cat. #3724; RRID: AB_1549585 Mouse monoclonal anti-Flag Cell Signaling Technology Cat. #8146; RRID: AB_10950495 Anti-rabbit IgG, HRP-linked Antibody Cell Signaling Technology Cat. #7074; RRID: AB_2099233 Bacterial and virus strains SARS-CoV-2 (hCoV-19/CHN/SYSU-IHV/ 2020 strain) Sun Yat-sen University GISAID: EPI_ISL_444969 AAV9-CAG-humanACE2-EGFP PackGene Biotech N/A AAV9-CAG-mACE2shRNA-EGFP PackGene Biotech N/A Chemicals, peptides, and recombinant proteins A779 MedChenExpress Cat. HY-P0216 Amsacrine MedChenExpress Cat. HY-13551 Anagrelide MedChenExpress Cat. HY-B0523A AZD-7762 MedChenExpress Cat. HY-10992 Clebopride MedChenExpress Cat. HY-B1613A Diminazene aceturate (DIZE) MedChenExpress Cat. HY-12404 Doxorubicin MedChenExpress Cat. HY-15142 DX600 MedChenExpress Cat. HY-P2222 Entinostat MedChenExpress Cat. HY-12163 Harpagoside MedChenExpress Cat. HY-N0396 Huperzine-A MedChenExpress Cat. HY-17387 Imatinib MedChenExpress Cat. HY-15463 Methazolamide MedChenExpress Cat. HY-B0553 Ofloxacin MedChenExpress Cat. HY-B0125 Pantoprazole MedChenExpress Cat. HY-17507 Phensuximide MedChenExpress Cat. HY-B(1730) Pyroxamide MedChenExpress Cat. HY-13216 Tranilast MedChenExpress Cat. HY-B0195 Xanthone MedChenExpress Cat. HY-N0126 Human angiotensin-I converting enzyme 2 (ACE2) Sino Biological Company Cat. 10108-H05H Human IL-4 Sino Biological Company Cat. 11846-HNAE Human IL-6 Sino Biological Company Cat. 10395-HNAE Human IFN-g Sino Biological Company Cat. 11725-HNAS Human TNF-a Sino Biological Company Cat. 10602-HNAE Critical commercial assays Human Angiotensin II ELISA kit CUSABIO Cat. CSB-E04493h Human Angiotensin-(1-7) ELISA kit CUSABIO Cat. CSB-E14242h Mouse TNF-a ELISA kit CUSABIO Cat. CSB-E04741m Mouse IL-6 ELISA kit CUSABIO Cat. CSB-E04639m (Continued on next page) e1 Cell Metabolism 34, 1–17.e1–e7, March 1, 2022 .. REAGENT or RESOURCE SOURCE IDENTIFIER Mouse Angiotensin II ELISA kit CUSABIO Cat. CSB-E04495m Mouse Angiotensin-(1-7) ELISA kit CUSABIO Cat. CSB-E13763m Mouse kidney injury molecule 1 (KIM-1) ELISA kit CUSABIO Cat. CSB-E08809m Mouse insulin ELISA kit CUSABIO Cat. CSB-E05071m RNA extraction reagent Accurate Biology Company Cat. AG21102 Evo M-MLV Reverse Transcription kit Accurate Biology Company Cat. AG11711 SYBR Green Premix Pro Taq HS qPCR kit Accurate Biology Company Cat. AG11701 ACE2 activity assay Kit (Fluorometric) Abcam Cat. ab273297 Triglyceride assay kits Nanjing Jiancheng Bioengineering Institute Cat. A110-1-1 Total cholesterol assay kits Nanjing Jiancheng Bioengineering Institute Cat. A111-1-1 HDL-C assay kits Nanjing Jiancheng Bioengineering Institute Cat. A112-1-1 LDL-C assay kits Nanjing Jiancheng Bioengineering Institute Cat. A113-1-1 Series S Sensor Chip CM7 GE Healthcare Life Sciences Cat. 10281415 Deposited data Raw RNA-seq data This paper GSA: HRA001795 Experimental models: Cell lines

    Recombinant:

    Article Title: Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry
    Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Rabbit monoclonal anti-FoxO1 Cell Signaling Technology Cat. #2880; RRID: AB_2106495 Rabbit polyclonal anti-ACE2 Abcam Cat. ab15348; RRID: AB_301861 Rabbit monoclonal anti-b-Actin Cell Signaling Technology Cat. #4970; RRID: AB_2223172 Rabbit monoclonal anti-SARS-CoV-2 Nucleocapsid Sino Biological Company Cat. # 40143-R001; RRID: AB_2827974 Rabbit monoclonal anti-HA Cell Signaling Technology Cat. #3724; RRID: AB_1549585 Mouse monoclonal anti-Flag Cell Signaling Technology Cat. #8146; RRID: AB_10950495 Anti-rabbit IgG, HRP-linked Antibody Cell Signaling Technology Cat. #7074; RRID: AB_2099233 Bacterial and virus strains SARS-CoV-2 (hCoV-19/CHN/SYSU-IHV/ 2020 strain) Sun Yat-sen University GISAID: EPI_ISL_444969 AAV9-CAG-humanACE2-EGFP PackGene Biotech N/A AAV9-CAG-mACE2shRNA-EGFP PackGene Biotech N/A Chemicals, peptides, and recombinant proteins A779 MedChenExpress Cat. HY-P0216 Amsacrine MedChenExpress Cat. HY-13551 Anagrelide MedChenExpress Cat. HY-B0523A AZD-7762 MedChenExpress Cat. HY-10992 Clebopride MedChenExpress Cat. HY-B1613A Diminazene aceturate (DIZE) MedChenExpress Cat. HY-12404 Doxorubicin MedChenExpress Cat. HY-15142 DX600 MedChenExpress Cat. HY-P2222 Entinostat MedChenExpress Cat. HY-12163 Harpagoside MedChenExpress Cat. HY-N0396 Huperzine-A MedChenExpress Cat. HY-17387 Imatinib MedChenExpress Cat. HY-15463 Methazolamide MedChenExpress Cat. HY-B0553 Ofloxacin MedChenExpress Cat. HY-B0125 Pantoprazole MedChenExpress Cat. HY-17507 Phensuximide MedChenExpress Cat. HY-B(1730) Pyroxamide MedChenExpress Cat. HY-13216 Tranilast MedChenExpress Cat. HY-B0195 Xanthone MedChenExpress Cat. HY-N0126 Human angiotensin-I converting enzyme 2 (ACE2) Sino Biological Company Cat. 10108-H05H Human IL-4 Sino Biological Company Cat. 11846-HNAE Human IL-6 Sino Biological Company Cat. 10395-HNAE Human IFN-g Sino Biological Company Cat. 11725-HNAS Human TNF-a Sino Biological Company Cat. 10602-HNAE Critical commercial assays Human Angiotensin II ELISA kit CUSABIO Cat. CSB-E04493h Human Angiotensin-(1-7) ELISA kit CUSABIO Cat. CSB-E14242h Mouse TNF-a ELISA kit CUSABIO Cat. CSB-E04741m Mouse IL-6 ELISA kit CUSABIO Cat. CSB-E04639m (Continued on next page) e1 Cell Metabolism 34, 1–17.e1–e7, March 1, 2022 .. REAGENT or RESOURCE SOURCE IDENTIFIER Mouse Angiotensin II ELISA kit CUSABIO Cat. CSB-E04495m Mouse Angiotensin-(1-7) ELISA kit CUSABIO Cat. CSB-E13763m Mouse kidney injury molecule 1 (KIM-1) ELISA kit CUSABIO Cat. CSB-E08809m Mouse insulin ELISA kit CUSABIO Cat. CSB-E05071m RNA extraction reagent Accurate Biology Company Cat. AG21102 Evo M-MLV Reverse Transcription kit Accurate Biology Company Cat. AG11711 SYBR Green Premix Pro Taq HS qPCR kit Accurate Biology Company Cat. AG11701 ACE2 activity assay Kit (Fluorometric) Abcam Cat. ab273297 Triglyceride assay kits Nanjing Jiancheng Bioengineering Institute Cat. A110-1-1 Total cholesterol assay kits Nanjing Jiancheng Bioengineering Institute Cat. A111-1-1 HDL-C assay kits Nanjing Jiancheng Bioengineering Institute Cat. A112-1-1 LDL-C assay kits Nanjing Jiancheng Bioengineering Institute Cat. A113-1-1 Series S Sensor Chip CM7 GE Healthcare Life Sciences Cat. 10281415 Deposited data Raw RNA-seq data This paper GSA: HRA001795 Experimental models: Cell lines

    Enzyme-linked Immunosorbent Assay:

    Article Title: Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry
    Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Rabbit monoclonal anti-FoxO1 Cell Signaling Technology Cat. #2880; RRID: AB_2106495 Rabbit polyclonal anti-ACE2 Abcam Cat. ab15348; RRID: AB_301861 Rabbit monoclonal anti-b-Actin Cell Signaling Technology Cat. #4970; RRID: AB_2223172 Rabbit monoclonal anti-SARS-CoV-2 Nucleocapsid Sino Biological Company Cat. # 40143-R001; RRID: AB_2827974 Rabbit monoclonal anti-HA Cell Signaling Technology Cat. #3724; RRID: AB_1549585 Mouse monoclonal anti-Flag Cell Signaling Technology Cat. #8146; RRID: AB_10950495 Anti-rabbit IgG, HRP-linked Antibody Cell Signaling Technology Cat. #7074; RRID: AB_2099233 Bacterial and virus strains SARS-CoV-2 (hCoV-19/CHN/SYSU-IHV/ 2020 strain) Sun Yat-sen University GISAID: EPI_ISL_444969 AAV9-CAG-humanACE2-EGFP PackGene Biotech N/A AAV9-CAG-mACE2shRNA-EGFP PackGene Biotech N/A Chemicals, peptides, and recombinant proteins A779 MedChenExpress Cat. HY-P0216 Amsacrine MedChenExpress Cat. HY-13551 Anagrelide MedChenExpress Cat. HY-B0523A AZD-7762 MedChenExpress Cat. HY-10992 Clebopride MedChenExpress Cat. HY-B1613A Diminazene aceturate (DIZE) MedChenExpress Cat. HY-12404 Doxorubicin MedChenExpress Cat. HY-15142 DX600 MedChenExpress Cat. HY-P2222 Entinostat MedChenExpress Cat. HY-12163 Harpagoside MedChenExpress Cat. HY-N0396 Huperzine-A MedChenExpress Cat. HY-17387 Imatinib MedChenExpress Cat. HY-15463 Methazolamide MedChenExpress Cat. HY-B0553 Ofloxacin MedChenExpress Cat. HY-B0125 Pantoprazole MedChenExpress Cat. HY-17507 Phensuximide MedChenExpress Cat. HY-B(1730) Pyroxamide MedChenExpress Cat. HY-13216 Tranilast MedChenExpress Cat. HY-B0195 Xanthone MedChenExpress Cat. HY-N0126 Human angiotensin-I converting enzyme 2 (ACE2) Sino Biological Company Cat. 10108-H05H Human IL-4 Sino Biological Company Cat. 11846-HNAE Human IL-6 Sino Biological Company Cat. 10395-HNAE Human IFN-g Sino Biological Company Cat. 11725-HNAS Human TNF-a Sino Biological Company Cat. 10602-HNAE Critical commercial assays Human Angiotensin II ELISA kit CUSABIO Cat. CSB-E04493h Human Angiotensin-(1-7) ELISA kit CUSABIO Cat. CSB-E14242h Mouse TNF-a ELISA kit CUSABIO Cat. CSB-E04741m Mouse IL-6 ELISA kit CUSABIO Cat. CSB-E04639m (Continued on next page) e1 Cell Metabolism 34, 1–17.e1–e7, March 1, 2022 .. REAGENT or RESOURCE SOURCE IDENTIFIER Mouse Angiotensin II ELISA kit CUSABIO Cat. CSB-E04495m Mouse Angiotensin-(1-7) ELISA kit CUSABIO Cat. CSB-E13763m Mouse kidney injury molecule 1 (KIM-1) ELISA kit CUSABIO Cat. CSB-E08809m Mouse insulin ELISA kit CUSABIO Cat. CSB-E05071m RNA extraction reagent Accurate Biology Company Cat. AG21102 Evo M-MLV Reverse Transcription kit Accurate Biology Company Cat. AG11711 SYBR Green Premix Pro Taq HS qPCR kit Accurate Biology Company Cat. AG11701 ACE2 activity assay Kit (Fluorometric) Abcam Cat. ab273297 Triglyceride assay kits Nanjing Jiancheng Bioengineering Institute Cat. A110-1-1 Total cholesterol assay kits Nanjing Jiancheng Bioengineering Institute Cat. A111-1-1 HDL-C assay kits Nanjing Jiancheng Bioengineering Institute Cat. A112-1-1 LDL-C assay kits Nanjing Jiancheng Bioengineering Institute Cat. A113-1-1 Series S Sensor Chip CM7 GE Healthcare Life Sciences Cat. 10281415 Deposited data Raw RNA-seq data This paper GSA: HRA001795 Experimental models: Cell lines



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    Journal: Cell Metabolism

    Article Title: Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry

    doi: 10.1016/j.cmet.2022.01.008

    Figure Lengend Snippet:

    Article Snippet: DX600 , MedChenExpress , Cat. HY-P2222.

    Techniques: Recombinant, Enzyme-linked Immunosorbent Assay, RNA Extraction, SYBR Green Assay, Activity Assay, Cholesterol Assay, Software

    Journal: Cell Metabolism

    Article Title: Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry

    doi: 10.1016/j.cmet.2022.01.008

    Figure Lengend Snippet:

    Article Snippet: DX600 , MedChenExpress , Cat. HY-P2222.

    Techniques: Virus, Recombinant, Enzyme-linked Immunosorbent Assay, RNA Extraction, Reverse Transcription, SYBR Green Assay, Activity Assay, Cholesterol Assay, Software