mots c (MedChemExpress)
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mots c
Mots C, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p2048a/MOTS-c/pmc06567243-186-10-19
Average 93 stars, based on 1 article reviews
Mots C, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p2048a/MOTS-c/pmc06567243-186-10-19
Average 93 stars, based on 1 article reviews
mots c - by Bioz Stars,
2026-10
93/100 stars
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Animal Model:Article Title: A mitochondrial-derived peptide MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier's ultrastructure. Article Snippet: Background: sepsis-associated encephalopathy (sae) is a serious complication of sepsis, increasing short-term and long-term mortality. it involves neuroinflammation, neuronal damage, and blood-brain barrier (BBB) disruption.. MOts-c, a mitochondrion-derived peptide, exerts neuroprotective effects by modulating inflammatory responses and cellular functions. this study explored the protective effects of MOts-c against brain injury in mice with lPs-induced sepsis.. Methods: a mouse model of sepsis was established via intraperitoneal injection of lPs. the mice were divided into four groups: control, control + MOts-c, lPs, and lPs + MOts-c groups. the mice in the latter two groups received MOts-c (20 mg/kg) four hours before model establishment. survival rates and the murine sepsis score (Mss) were recorded. h&e staining, elisa, evans blue staining, brain water content detremination, immunofluorescence staining, western blotting, and qPcR were performed to assess brain tissue damage, inflammation, BBB permeability, and BBB-related protein expression. Control:Article Title: A mitochondrial-derived peptide MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier's ultrastructure. Article Snippet: Background: sepsis-associated encephalopathy (sae) is a serious complication of sepsis, increasing short-term and long-term mortality. it involves neuroinflammation, neuronal damage, and blood-brain barrier (BBB) disruption.. MOts-c, a mitochondrion-derived peptide, exerts neuroprotective effects by modulating inflammatory responses and cellular functions. this study explored the protective effects of MOts-c against brain injury in mice with lPs-induced sepsis.. Methods: a mouse model of sepsis was established via intraperitoneal injection of lPs. the mice were divided into four groups: control, control + MOts-c, lPs, and lPs + MOts-c groups. the mice in the latter two groups received MOts-c (20 mg/kg) four hours before model establishment. survival rates and the murine sepsis score (Mss) were recorded. h&e staining, elisa, evans blue staining, brain water content detremination, immunofluorescence staining, western blotting, and qPcR were performed to assess brain tissue damage, inflammation, BBB permeability, and BBB-related protein expression. Injection:Article Title: A mitochondrial-derived peptide MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier's ultrastructure. Article Snippet: Background: sepsis-associated encephalopathy (sae) is a serious complication of sepsis, increasing short-term and long-term mortality. it involves neuroinflammation, neuronal damage, and blood-brain barrier (BBB) disruption.. MOts-c, a mitochondrion-derived peptide, exerts neuroprotective effects by modulating inflammatory responses and cellular functions. this study explored the protective effects of MOts-c against brain injury in mice with lPs-induced sepsis.. Methods: a mouse model of sepsis was established via intraperitoneal injection of lPs. the mice were divided into four groups: control, control + MOts-c, lPs, and lPs + MOts-c groups. the mice in the latter two groups received MOts-c (20 mg/kg) four hours before model establishment. survival rates and the murine sepsis score (Mss) were recorded. h&e staining, elisa, evans blue staining, brain water content detremination, immunofluorescence staining, western blotting, and qPcR were performed to assess brain tissue damage, inflammation, BBB permeability, and BBB-related protein expression. Saline:Article Title: A mitochondrial-derived peptide MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier's ultrastructure. Article Snippet: Background: sepsis-associated encephalopathy (sae) is a serious complication of sepsis, increasing short-term and long-term mortality. it involves neuroinflammation, neuronal damage, and blood-brain barrier (BBB) disruption.. MOts-c, a mitochondrion-derived peptide, exerts neuroprotective effects by modulating inflammatory responses and cellular functions. this study explored the protective effects of MOts-c against brain injury in mice with lPs-induced sepsis.. Methods: a mouse model of sepsis was established via intraperitoneal injection of lPs. the mice were divided into four groups: control, control + MOts-c, lPs, and lPs + MOts-c groups. the mice in the latter two groups received MOts-c (20 mg/kg) four hours before model establishment. survival rates and the murine sepsis score (Mss) were recorded. h&e staining, elisa, evans blue staining, brain water content detremination, immunofluorescence staining, western blotting, and qPcR were performed to assess brain tissue damage, inflammation, BBB permeability, and BBB-related protein expression. Bacteria:Article Title: MOTS-c peptide increases survival and decreases bacterial load in mice infected with MRSA. Article Snippet: Sepsis is a life-threatening disease characterized by uncontrolled inflammatory responses upon pathogen infections, especially for the antibiotic-resistant strains, such as Methicillin-resistant S. aureus (MRSA).. Here we demonstrated that a Mitochondria-derived peptide (MOTS-c) could significantly improve the survival rate and decrease bacteria loads in MRSA-challenged mice, accompanied with declined levels of pro-inflammatory cytokines, such as TNF-α, IL-6 and IL-1β, but with increased level of anti-inflammatory cytokine IL-10.. Moreover this peptide enhanced bactericidal capacity of macrophages. |