apelin 13 (MedChemExpress)
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MedChemExpress
apelin 13
Apelin 13, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 28 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p1944/Apelin-13/pmc08549912-53-23-48
Average 95 stars, based on 28 article reviews
Apelin 13, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 28 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p1944/Apelin-13/pmc08549912-53-23-48
Average 95 stars, based on 28 article reviews
apelin 13 - by Bioz Stars,
2026-10
95/100 stars
Images
1) Product Images from "Apelin-13 Regulates Angiotensin II-Induced Cx43 Downregulation and Autophagy via the AMPK/mTOR Signaling Pathway in HL-1 Cells"
Article Title: Apelin-13 Regulates Angiotensin II-Induced Cx43 Downregulation and Autophagy via the AMPK/mTOR Signaling Pathway in HL-1 Cells
Journal: Physiological Research
doi: 10.33549/physiolres.934488
Figure Legend Snippet: Effect of AngII and apelin-13 on Cx43 expression in HL-1 cells. AngII (10 μM, 48 h) downregulated Cx43 expression (A), whereas apelin-13 (100 nM, 48 h) had no significant effect on Cx43 expression at the various concentrations used (B). Subsequent incubation with both AngII and apelin-13 restored the Cx43 downregulation induced by AngII (C). Control: normal incubation; AngII: angiotensin II; AP: apelin-13. n=5; ** p<0.01, vs. control; * p<0.05, vs. AngII; # p<0.05, vs. AngII.
Techniques Used: Expressing, Incubation, Control
Figure Legend Snippet: The effects of compound C and rapamycin on Cx43 expression and distribution. Cx43 expression and distribution in HL-1 cells was determined by cell immunofluores-cence and Western blot analysis. (A) Compared with the control group, Cx43 expression and distribution in the AngII group was decreased, whereas addition of apelin-13 restored Cx43 expression. Under the treatment of AngII and apelin-13, adding CC or Ra downregulated the expression and distribution of Cx43. (B, C) n=6; * p<0.05 vs. AngII+AP; ** p<0.01 vs. AngII; *** p<0.001 vs. Control; &&& p<0.001 vs. AngII+AP.
Techniques Used: Expressing, Western Blot, Control
Figure Legend Snippet: Functional pathway diagram. Schematic representation showing that apelin-13 increased autophagy and Cx43 expression through an AMPK/mTOR signaling pathway but decreased cell hypertrophy in HL-1 cells. In addition, increased autophagy decreased the expression of Cx43 and promoted cell hypertrophy.
Techniques Used: Functional Assay, Expressing
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