aunp 12 (MedChemExpress)
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aunp 12
Aunp 12, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p1812/AUNP-12/pm38980173-166-39-41
Average 92 stars, based on 2 article reviews
Aunp 12, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p1812/AUNP-12/pm38980173-166-39-41
Average 92 stars, based on 2 article reviews
aunp 12 - by Bioz Stars,
2026-10
92/100 stars
Images
1) Product Images from "AUNP-12 Near-Infrared Fluorescence Probes across NIR-I to NIR-II Enable In Vivo Detection of PD-1/PD-L1 Axis in the Tumor Microenvironment."
Article Title: AUNP-12 Near-Infrared Fluorescence Probes across NIR-I to NIR-II Enable In Vivo Detection of PD-1/PD-L1 Axis in the Tumor Microenvironment.
Journal: Bioconjugate chemistry
doi: 10.1021/acs.bioconjchem.4c00266
Figure Legend Snippet: Figure 1. Characterization of AUNP-12-Cy5.5 and AUNP-12-CH1055. (A, B) Absorbance spectra and fluorescence intensities of AUNP-12-Cy5.5 and AUNP-12-CH1055. (C) ζ-Potential of AUNP-12-Cy5.5 in different solvents. (D) NIR-I fluorescence intensities of AUNP-12-Cy5.5 with different concentrations. (E) Fluorescence intensities under different long-pass filters of AUNP-12-CH1055. (F) NIR-II fluorescence intensity of AUNP-12-CH1055 at different concentrations.
Techniques Used: Fluorescence
Figure Legend Snippet: Figure 2. Expression characteristics of PD-L1 and targeting of AUNP-12-Cy5.5 in vitro. (A, B) PD-L1 showed varying expression levels across several cancer cell lines: higher in B16F10, CT26, and MDA-MB-231 and lower in 4T1 and MCF-7. (C) Flow cytometry indicated that AUNP-12- Cy5.5 more effectively targeted CT26 cells (high PD-L1 expression) in the AUNP-12-Cy5.5 group.
Techniques Used: Expressing, In Vitro, Flow Cytometry
Figure Legend Snippet: Figure 3. In vivo NIR-I imaging and biodistribution of AUNP-12-Cy5.5 for the subcutaneous mouse tumor models. (A) Fluorescence images of the 4T1 subcutaneous mouse tumor models in vivo at different time points (n = 3). (B) Ex vivo fluorescence images of the 4T1 subcutaneous mouse tumor models. (C) Quantitative analysis of TBR over 24 h. (D) Fluorescence images of the CT26 subcutaneous mouse tumor models in vivo at different time points (n = 3). (E) Ex vivo fluorescence images of the CT26 subcutaneous mouse tumor models. (F) Quantitative analysis of TBR over 24 h. (G) 3D LSFM images of tumors in the 4T1 and CT26 subcutaneous mouse tumor models. Scale bars: 200 μm. TBR: tumor-to- background ratio. The data were presented as mean ± standard error of the mean (SEM) *p < 0.05, **p < 0.01, ***p < 0.001.
Techniques Used: In Vivo, Imaging, Fluorescence, Ex Vivo
Figure Legend Snippet: Figure 4. In vivo NIR-I imaging and biodistribution of AUNP-12-Cy5.5 in the MDA-MB-231 tumor (left) and MCF-7 tumor (right). (A) In vivo fluorescence images of bilateral mammary gland mouse tumor models at different time points (n = 3). (B−D) Quantitative analysis of TBR in MDA-MB-231 and MCF-7 tumors over 24 h. (E) Ex vivo fluorescence images of bilateral mammary gland mouse tumor models. TBR: tumor-to- background ratio. The data were presented as mean ± SEM *p < 0.05, **p < 0.01, ***p < 0.001.
Techniques Used: In Vivo, Imaging, Fluorescence, Ex Vivo
Figure Legend Snippet: Figure 5. In vivo NIR-II imaging and biodistribution of AUNP-12-CH1055 in the 4T1 subcutaneous mouse tumor models. (A) Fluorescence images of the 4T1 subcutaneous mouse tumor models in vivo at different time points (n = 3). (B) Quantitative analysis of mean fluorescence intensity over 48 h. The fluorescence intensity of tumors in AUNP-12-CH1055 groups was higher than that in the two block groups after injection of AUNP-12-CH1055. (C) Ex vivo fluorescence images of tumors and major organs. The data were presented as mean ± SEM *p < 0.05, **p < 0.01, ***p < 0.001.
Techniques Used: In Vivo, Imaging, Fluorescence, Blocking Assay, Injection, Ex Vivo
Figure Legend Snippet: Figure 6. Assessment of the safety of two imaging probes. The mice were sacrificed after 7 days treatment, and serum and major organs were collected. Assessment of liver (A, B) and renal (C) functions in mice treated with PBS, AUNP-12-Cy5.5, or AUNP-12-CH1055. (D) H&E staining of major organs after treatment with PBS, AUNP-12-Cy5.5, or AUNP-12-CH1055. Scale bars: 50 μm.
Techniques Used: Imaging, Staining
Related Articles
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