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vnp counterparts (MedChemExpress)

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MedChemExpress vnp counterparts
Vnp Counterparts, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p1556a/Vasonatrin+Peptide/10__1109_slash_tgrs__2023__3261664-384-13-21
Average 92 stars, based on 3 article reviews

vnp counterparts - by Bioz Stars, 2026-10

92/100 stars

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Article Title: Neutrophil-Mediated Tumor-Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis Therapy.
Article Snippet: .. Neutrophil Phagocytosing VNP and Fluorescent Microbeads: Neutrophils were stimulated with 5 × 10−3 m GSK484 (an inhibitor of peptidyl arginine deiminase 4 (PAD4), the key gene of neutrophil extracellular traps production) (HY-100514, MCE) for 30 min. After that, VNP (MOI = 100:1) were incubated with neutrophil for 0.5, 1.5, or 2.5 h at 37 °C in an incubator with 5% CO2. .. And then, 45 μg mL −1 gentamicin sulfate (B540724-0010, Sangon Biotech) was added to the medium for 1 h, owing to killing bacteria on neutrophil surfaces.

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A : Effects of the investigated drugs on erythema. B : Effects of the investigated drugs on scaling. C : Effects of the investigated drugs on dorsal skin thickness. D : Effects of the investigated drugs on right ear skin thickness. Data are presented as mean ± SD. IMQ = imiquimod, CLO = clobetasol, and CLO + VNP = clobetasol plus vinpocetine. ∗ p < 0.001 compared with healthy controls; ∗∗ p < 0.01 compared with the IMQ 5% induction group ; #p < 0.05 compared with the 0.05% CLO group, n = 8 .

Journal: Journal of Taibah University Medical Sciences

Article Title: Attenuated effects of topical vinpocetine in an imiquimod-induced mouse model of psoriasis

doi: 10.1016/j.jtumed.2023.09.002

Figure Lengend Snippet: A : Effects of the investigated drugs on erythema. B : Effects of the investigated drugs on scaling. C : Effects of the investigated drugs on dorsal skin thickness. D : Effects of the investigated drugs on right ear skin thickness. Data are presented as mean ± SD. IMQ = imiquimod, CLO = clobetasol, and CLO + VNP = clobetasol plus vinpocetine. ∗ p < 0.001 compared with healthy controls; ∗∗ p < 0.01 compared with the IMQ 5% induction group ; #p < 0.05 compared with the 0.05% CLO group, n = 8 .

Article Snippet: IMQ (5% w/w) was manufactured by MEDA Pharmaceutical Co. (Sweden), and VNP was provided by MedChem Express (USA) for animal investigations.

Techniques:

Mean tissue concentrations of TNF-α and IL-17A. IMQ = imiquimod, CLO = clobetasol, VNP = vinpocetine, CLO + VNP = clobetasol plus vinpocetine. Data are shown as mean ± SD. ∗p < 0.001 compared with the control group; ∗∗p < 0.01 compared with the IMQ induction group; #p < 0.05 compared with the 0.05% CLO group, n = 8 .

Journal: Journal of Taibah University Medical Sciences

Article Title: Attenuated effects of topical vinpocetine in an imiquimod-induced mouse model of psoriasis

doi: 10.1016/j.jtumed.2023.09.002

Figure Lengend Snippet: Mean tissue concentrations of TNF-α and IL-17A. IMQ = imiquimod, CLO = clobetasol, VNP = vinpocetine, CLO + VNP = clobetasol plus vinpocetine. Data are shown as mean ± SD. ∗p < 0.001 compared with the control group; ∗∗p < 0.01 compared with the IMQ induction group; #p < 0.05 compared with the 0.05% CLO group, n = 8 .

Article Snippet: IMQ (5% w/w) was manufactured by MEDA Pharmaceutical Co. (Sweden), and VNP was provided by MedChem Express (USA) for animal investigations.

Techniques: Control

Mean tissue concentrations of IL-8, NF-κB, and TGF-β1. IMQ = imiquimod, CLO = clobetasol, VNP = vinpocetine, CLO + VNP = clobetasol plus vinpocetine. Data are shown as mean ± SD. ∗p < 0.001 compared with the control group; ∗∗p < 0.01 compared with the IMQ induction group; #p < 0.05 compared with the 0.05% CLO group, n = 8 .

Journal: Journal of Taibah University Medical Sciences

Article Title: Attenuated effects of topical vinpocetine in an imiquimod-induced mouse model of psoriasis

doi: 10.1016/j.jtumed.2023.09.002

Figure Lengend Snippet: Mean tissue concentrations of IL-8, NF-κB, and TGF-β1. IMQ = imiquimod, CLO = clobetasol, VNP = vinpocetine, CLO + VNP = clobetasol plus vinpocetine. Data are shown as mean ± SD. ∗p < 0.001 compared with the control group; ∗∗p < 0.01 compared with the IMQ induction group; #p < 0.05 compared with the 0.05% CLO group, n = 8 .

Article Snippet: IMQ (5% w/w) was manufactured by MEDA Pharmaceutical Co. (Sweden), and VNP was provided by MedChem Express (USA) for animal investigations.

Techniques: Control

Histological skin sections of mouse groups stained with haematoxylin and eosin at 10× magnification. Group 1 (control) showed normal skin structures, including the keratin skin layers (yellow line), epidermis (red line), dermis (green line), and sebaceous glands (blue line). Group II (IMQ group) tissue demonstrated hallmarks of psoriasis, including marked epidermal inflammatory processes (yellow line), prominent rete processes thinning (red line), intense hyperkeratotic lesions (green line), and marked acanthotic alterations (blue line). Group III (CLO group) showed mild psoriasis inflammation (yellow line), moderate rete peg lengthening (red line), mild hyperkeratotic lesions (green line), and mild acanthotic changes (blue line). Mice subjected to 1% VNP (group IV) exhibited modest inflammation (yellow line), mild extension of rete pegs (red line), minor hyperkeratotic lesions (green line), and modest acanthotic modifications (blue line). Group V (3% VNP) mice had mild skin inflammation (yellow line), absence of rete ridge processes (red line), absence of hyperkeratotic signs (green line), and absence of acanthotic alterations (blue line). Mice in group V (CLO + VNP) displayed modest epidermal inflammation (yellow line), absence of rete ridge processes (red line), absence of hyperkeratotic signs (green line), and a lack of acanthotic changes (blue line).

Journal: Journal of Taibah University Medical Sciences

Article Title: Attenuated effects of topical vinpocetine in an imiquimod-induced mouse model of psoriasis

doi: 10.1016/j.jtumed.2023.09.002

Figure Lengend Snippet: Histological skin sections of mouse groups stained with haematoxylin and eosin at 10× magnification. Group 1 (control) showed normal skin structures, including the keratin skin layers (yellow line), epidermis (red line), dermis (green line), and sebaceous glands (blue line). Group II (IMQ group) tissue demonstrated hallmarks of psoriasis, including marked epidermal inflammatory processes (yellow line), prominent rete processes thinning (red line), intense hyperkeratotic lesions (green line), and marked acanthotic alterations (blue line). Group III (CLO group) showed mild psoriasis inflammation (yellow line), moderate rete peg lengthening (red line), mild hyperkeratotic lesions (green line), and mild acanthotic changes (blue line). Mice subjected to 1% VNP (group IV) exhibited modest inflammation (yellow line), mild extension of rete pegs (red line), minor hyperkeratotic lesions (green line), and modest acanthotic modifications (blue line). Group V (3% VNP) mice had mild skin inflammation (yellow line), absence of rete ridge processes (red line), absence of hyperkeratotic signs (green line), and absence of acanthotic alterations (blue line). Mice in group V (CLO + VNP) displayed modest epidermal inflammation (yellow line), absence of rete ridge processes (red line), absence of hyperkeratotic signs (green line), and a lack of acanthotic changes (blue line).

Article Snippet: IMQ (5% w/w) was manufactured by MEDA Pharmaceutical Co. (Sweden), and VNP was provided by MedChem Express (USA) for animal investigations.

Techniques: Staining, Control

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