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neuropeptide s  (MedChemExpress)


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    Structured Review

    MedChemExpress neuropeptide s
    Neuropeptide S, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-p1389/Neuropeptide+S/pm41619995-83-0-2
    Average 94 stars, based on 1 article reviews
    neuropeptide s - by Bioz Stars, 2026-10
    94/100 stars

    Images

    Related Articles

    Blocking Assay:

    Article Title: Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis.
    Article Snippet: Local Joint Administration of 4-Hydroxytamoxifen, CGRP and BIBN4096: To modulate neuropeptide levels, CGRP (2 μg/5 μL, MedChemExpress, Cat. No. HY-P0203A) and the vehicle control were preinjected intraarticularly into the knee joint cavities of the mice 2 h prior to infection. .. To block neuropeptide, CGRP receptor antagonist BIBN4096 (5 μg/5 μL, MedChemExpress, Cat. No. HY-10095), along with vehicle controls, were administered via intra-articular injection into the knee joint 2 h before infection, followed by weekly injections thereafter. ..

    Injection:

    Article Title: Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis.
    Article Snippet: Local Joint Administration of 4-Hydroxytamoxifen, CGRP and BIBN4096: To modulate neuropeptide levels, CGRP (2 μg/5 μL, MedChemExpress, Cat. No. HY-P0203A) and the vehicle control were preinjected intraarticularly into the knee joint cavities of the mice 2 h prior to infection. .. To block neuropeptide, CGRP receptor antagonist BIBN4096 (5 μg/5 μL, MedChemExpress, Cat. No. HY-10095), along with vehicle controls, were administered via intra-articular injection into the knee joint 2 h before infection, followed by weekly injections thereafter. ..

    Infection:

    Article Title: Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis.
    Article Snippet: Local Joint Administration of 4-Hydroxytamoxifen, CGRP and BIBN4096: To modulate neuropeptide levels, CGRP (2 μg/5 μL, MedChemExpress, Cat. No. HY-P0203A) and the vehicle control were preinjected intraarticularly into the knee joint cavities of the mice 2 h prior to infection. .. To block neuropeptide, CGRP receptor antagonist BIBN4096 (5 μg/5 μL, MedChemExpress, Cat. No. HY-10095), along with vehicle controls, were administered via intra-articular injection into the knee joint 2 h before infection, followed by weekly injections thereafter. ..

    Article Title: Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis.
    Article Snippet: .. Local Joint Administration of 4-Hydroxytamoxifen, CGRP and BIBN4096: To modulate neuropeptide levels, CGRP (2 μg/5 μL, MedChemExpress, Cat. No. HY-P0203A) and the vehicle control were preinjected intraarticularly into the knee joint cavities of the mice 2 h prior to infection. .. To block neuropeptide, CGRP receptor antagonist BIBN4096 (5 μg/5 μL, MedChemExpress, Cat. No. HY-10095), along with vehicle controls, were administered via intra-articular injection into the knee joint 2 h before infection, followed by weekly injections thereafter.

    Article Title: Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis
    Article Snippet: .. To modulate neuropeptide levels, CGRP (2 μg/5 μL, MedChemExpress, Cat. No. HY‐P0203A) and the vehicle control were preinjected intra‐articularly into the knee joint cavities of the mice 2 h prior to infection. .. To block neuropeptide, CGRP receptor antagonist BIBN4096 (5 μg/5 μL, MedChemExpress, Cat. No. HY‐10095), along with vehicle controls, were administered via intra‐articular injection into the knee joint 2 h before infection, followed by weekly injections thereafter.

    Control:

    Article Title: Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis.
    Article Snippet: .. Local Joint Administration of 4-Hydroxytamoxifen, CGRP and BIBN4096: To modulate neuropeptide levels, CGRP (2 μg/5 μL, MedChemExpress, Cat. No. HY-P0203A) and the vehicle control were preinjected intraarticularly into the knee joint cavities of the mice 2 h prior to infection. .. To block neuropeptide, CGRP receptor antagonist BIBN4096 (5 μg/5 μL, MedChemExpress, Cat. No. HY-10095), along with vehicle controls, were administered via intra-articular injection into the knee joint 2 h before infection, followed by weekly injections thereafter.

    Article Title: GLX351322-Loaded Nanoparticles Alleviate Chronic Stress-Induced Depressive Behaviors Through Inhibition of Ferroptosis and Oxidative Stress
    Article Snippet: .. Experiment 2: This experiment consisted of five groups of mice (n = 6 per group): Control, CUMS, CUMS + GLX-NPs (5 mg/kg), CUMS + GLX-NPs + RSL3 (5.0 mg/kg, HY-100218A, MCE, USA), and CUMS + Ferrostatin-1 (Fer-1, 5.0 mg/kg, HY-100579, MCE, USA). ..

    Article Title: Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis
    Article Snippet: .. To modulate neuropeptide levels, CGRP (2 μg/5 μL, MedChemExpress, Cat. No. HY‐P0203A) and the vehicle control were preinjected intra‐articularly into the knee joint cavities of the mice 2 h prior to infection. .. To block neuropeptide, CGRP receptor antagonist BIBN4096 (5 μg/5 μL, MedChemExpress, Cat. No. HY‐10095), along with vehicle controls, were administered via intra‐articular injection into the knee joint 2 h before infection, followed by weekly injections thereafter.

    Saline:

    Article Title: The analgesic effect of neuropeptide S (NPS) in alcohol-dependent male and female rats.
    Article Snippet: Introduction: Alcohol dependence (AD) includes tolerance to alcohol's analgesic effects and increased pain sensitivity during withdrawal (i.e., hyperalgesia).. Further, the reciprocal relationship between alcohol use and pain sensitivity is hypothesized to contribute to the maintenance of AD through negative reinforcement (i.e., selfmedication).. The neuropeptide S (NPS) system, known to regulate stress, arousal, and pain pathways, may offer a therapeutic target to ameliorate AD-induced hyperalgesia.

    Cytotoxicity Assay:

    Article Title: Novel Dual-Mode NIR-II/MRI Nanoprobe Targeting PD-L1 Accurately Evaluates the Efficacy of Immunotherapy for Triple-Negative Breast Cancer
    Article Snippet: .. Cytotoxicity Assay NPs-Ate cytotoxicity was assessed using the Cell Counting Kit-8 (CCK8) method MedChemExpress (USA). ..

    CCK-8 Assay:

    Article Title: Novel Dual-Mode NIR-II/MRI Nanoprobe Targeting PD-L1 Accurately Evaluates the Efficacy of Immunotherapy for Triple-Negative Breast Cancer
    Article Snippet: .. Cytotoxicity Assay NPs-Ate cytotoxicity was assessed using the Cell Counting Kit-8 (CCK8) method MedChemExpress (USA). ..



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    Image Search Results


    GLX-NPs alleviate depression-like behaviors in CUMS-exposed mice. ( A ) Body weight of mice (n = 6). ( B ) Average velocity in the OFT (n = 6). ( C ) Total distance traveled in the OFT (n = 6). ( D ) Time spent in the center zone during the OFT (n = 6). ( E ) Representative heatmaps of locomotor trajectories in the OFT. ( F ) Immobility time in the TST (n = 6). ( G ) Immobility time in the FST (n = 6). ( H ) Sucrose consumption in the SPT (n = 6). ( I ) Serum CORT levels (n = 6). ( J ) Representative H&E staining of the hippocampal CA1, CA3, and DG regions. The yellow boxes indicate the zoom-in areas. Scale bar = 20 μm. ( K ) Representative Nissl staining of the hippocampal CA1, CA3, and DG regions in each group. The yellow boxes indicate the zoom-in areas. Scale bar=20 μm. Values are presented as the mean ± SD. *p<0.05, ***p<0.001.

    Journal: International Journal of Nanomedicine

    Article Title: GLX351322-Loaded Nanoparticles Alleviate Chronic Stress-Induced Depressive Behaviors Through Inhibition of Ferroptosis and Oxidative Stress

    doi: 10.2147/IJN.S555165

    Figure Lengend Snippet: GLX-NPs alleviate depression-like behaviors in CUMS-exposed mice. ( A ) Body weight of mice (n = 6). ( B ) Average velocity in the OFT (n = 6). ( C ) Total distance traveled in the OFT (n = 6). ( D ) Time spent in the center zone during the OFT (n = 6). ( E ) Representative heatmaps of locomotor trajectories in the OFT. ( F ) Immobility time in the TST (n = 6). ( G ) Immobility time in the FST (n = 6). ( H ) Sucrose consumption in the SPT (n = 6). ( I ) Serum CORT levels (n = 6). ( J ) Representative H&E staining of the hippocampal CA1, CA3, and DG regions. The yellow boxes indicate the zoom-in areas. Scale bar = 20 μm. ( K ) Representative Nissl staining of the hippocampal CA1, CA3, and DG regions in each group. The yellow boxes indicate the zoom-in areas. Scale bar=20 μm. Values are presented as the mean ± SD. *p<0.05, ***p<0.001.

    Article Snippet: Experiment 2: This experiment consisted of five groups of mice (n = 6 per group): Control, CUMS, CUMS + GLX-NPs (5 mg/kg), CUMS + GLX-NPs + RSL3 (5.0 mg/kg, HY-100218A, MCE, USA), and CUMS + Ferrostatin-1 (Fer-1, 5.0 mg/kg, HY-100579, MCE, USA).

    Techniques: Staining

    The antidepressant effect of GLX-NPs in CUMS mice is reversed by RSL3. ( A ) Representative heatmaps of locomotor trajectories in the OFT. ( B ) Time spent in the center zone during the OFT (n=6). ( C ) Immobility time in the TST (n=6). ( D ) Immobility time in the FST (n=6). ( E ) Sucrose consumption in the SPT (n=6). ( F ) Representative images of NOX4 and NeuN immunofluorescence staining in the hippocampal CA1, CA3, and DG regions across different groups. Scale bar = 20 μm. ( G – I ) Fluorescence quantification of NOX4⁺/NeuN⁺ cells in the hippocampus (n=3). Values are expressed as mean ± SD. **p<0.01, ***p<0.001.

    Journal: International Journal of Nanomedicine

    Article Title: GLX351322-Loaded Nanoparticles Alleviate Chronic Stress-Induced Depressive Behaviors Through Inhibition of Ferroptosis and Oxidative Stress

    doi: 10.2147/IJN.S555165

    Figure Lengend Snippet: The antidepressant effect of GLX-NPs in CUMS mice is reversed by RSL3. ( A ) Representative heatmaps of locomotor trajectories in the OFT. ( B ) Time spent in the center zone during the OFT (n=6). ( C ) Immobility time in the TST (n=6). ( D ) Immobility time in the FST (n=6). ( E ) Sucrose consumption in the SPT (n=6). ( F ) Representative images of NOX4 and NeuN immunofluorescence staining in the hippocampal CA1, CA3, and DG regions across different groups. Scale bar = 20 μm. ( G – I ) Fluorescence quantification of NOX4⁺/NeuN⁺ cells in the hippocampus (n=3). Values are expressed as mean ± SD. **p<0.01, ***p<0.001.

    Article Snippet: Experiment 2: This experiment consisted of five groups of mice (n = 6 per group): Control, CUMS, CUMS + GLX-NPs (5 mg/kg), CUMS + GLX-NPs + RSL3 (5.0 mg/kg, HY-100218A, MCE, USA), and CUMS + Ferrostatin-1 (Fer-1, 5.0 mg/kg, HY-100579, MCE, USA).

    Techniques: Immunofluorescence, Staining, Fluorescence

    GLX-NPs significantly reduce ferroptosis and OS in CUMS mice. ( A ) Representative immunofluorescence images of GPX4 and NeuN staining in the hippocampal CA1, CA3, and DG regions across different groups. Scale bar = 20 μm. ( B – D ) Fluorescence quantification of NOX4⁺/NeuN⁺ cells in the hippocampus (n=3). ( E ) Fe 2+ content in the hippocampus (n = 3). ( F – I ) Levels of LPO, MDA, GSH, and SOD in the hippocampus of mice from different groups (n=3-4). ( J ) Representative TEM images of the hippocampus from different treatment groups. Normal mitochondria are indicated by green arrows, and mitochondria with ferroptosis-like features are indicated by red arrows. Scale bar=1 μm. Data are presented as mean ± SD. **p<0.01, ***p<0.001.

    Journal: International Journal of Nanomedicine

    Article Title: GLX351322-Loaded Nanoparticles Alleviate Chronic Stress-Induced Depressive Behaviors Through Inhibition of Ferroptosis and Oxidative Stress

    doi: 10.2147/IJN.S555165

    Figure Lengend Snippet: GLX-NPs significantly reduce ferroptosis and OS in CUMS mice. ( A ) Representative immunofluorescence images of GPX4 and NeuN staining in the hippocampal CA1, CA3, and DG regions across different groups. Scale bar = 20 μm. ( B – D ) Fluorescence quantification of NOX4⁺/NeuN⁺ cells in the hippocampus (n=3). ( E ) Fe 2+ content in the hippocampus (n = 3). ( F – I ) Levels of LPO, MDA, GSH, and SOD in the hippocampus of mice from different groups (n=3-4). ( J ) Representative TEM images of the hippocampus from different treatment groups. Normal mitochondria are indicated by green arrows, and mitochondria with ferroptosis-like features are indicated by red arrows. Scale bar=1 μm. Data are presented as mean ± SD. **p<0.01, ***p<0.001.

    Article Snippet: Experiment 2: This experiment consisted of five groups of mice (n = 6 per group): Control, CUMS, CUMS + GLX-NPs (5 mg/kg), CUMS + GLX-NPs + RSL3 (5.0 mg/kg, HY-100218A, MCE, USA), and CUMS + Ferrostatin-1 (Fer-1, 5.0 mg/kg, HY-100579, MCE, USA).

    Techniques: Immunofluorescence, Staining, Fluorescence