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cyclotraxin b (MedChemExpress)

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MedChemExpress cyclotraxin b
Cyclotraxin B, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p1178/Cyclotraxin+B/bio_rxiv__2025__11__18__689087-187-32-40
Average 93 stars, based on 6 article reviews

cyclotraxin b - by Bioz Stars, 2026-10

93/100 stars

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Microinjection:

Article Title: Alteration of neural activity and neuroinflammatory factors in the insular cortex of mice with corneal neuropathic pain.
Article Snippet: .. The DE + cyclotraxin-B group represents that of dry eye mice receiving an intrainsular cortical microinjection of cyclotraxin-B (10 and 0.05 μL per side; MCE). (F–I) The chemical and mechanical thresholds after administration of cyclotraxin-B in DE mice (n = 8, **p < 0.01, ***p < 0.001 and ****p < 0.0001 vs. DE + saline group). (J) Representative activity tracking OFT in Sham, DE, DE + cyclotraxin-B, DE + saline mice. (K,L) Time in center region (K) and total distance traveled (L) during OFT (n = 6, ****p < 0.0001 vs. Sham group). ..

Saline:

other:

Article Title: Dissection of signaling pathways regulating TrkB-dependent gephyrin clustering.
Article Snippet: At DIV14, the cells were washed and treated with 145 mM NaCl, 2 mM KCl, 2 mM CaCl, 2 mM MgCl, 10 mM Glucose, 10 mM HEPES (Pennacchietti et al., 2017) supplemented with 20 μM NMDA and 10 μM CNQX (MedChemExpress, Monmouth Junction, NJ) for 2 min, followed by a recovery period in the treatment solution for 18 min. To inhibit MEK1, CaMKII or TrkB, neurons were treated with either 50 μM PD98059, 3 μM KN-62, 1 μM Cyclotraxin B (all from MedChemExpress, Monmouth Junction, NJ) or DMSO (CTR) for 30 min in culture medium before induction of chem iLTP as described.

Article Title: Dissection of signaling pathways regulating TrkB-dependent gephyrin clustering
Article Snippet: At DIV14, the cells were washed and treated with 145 mM NaCl, 2 mM KCl, 2 mM CaCl, 2 mM MgCl, 10 mM Glucose, 10 mM HEPES ( ) supplemented with 20 μM NMDA and 10 μM CNQX (MedChemExpress, Monmouth Junction, NJ) for 2 min, followed by a recovery period in the treatment solution for 18 min. To inhibit MEK1, CaMKII or TrkB, neurons were treated with either 50 μM PD98059, 3 μM KN-62, 1 μM Cyclotraxin B (all from MedChemExpress, Monmouth Junction, NJ) or DMSO (CTR) for 30 min in culture medium before induction of chem iLTP as described.

Activity Assay:

Image Search Results

NHQXW regulated the TrkB/ERK/CREB pathway in the hippocampus of CCS mice. The results were presented in 4 groups: vehicle-treated normal control group, CORT stress group, stress plus NQHXW treatment groups at a dosage of 20 mg/kg, and FLX treatment group. The sample size for all groups was 4-5. (A) Representative immunoblot results for the expression of BDNF, TrkB, p-ERK (T202/T204), p-MEK1/2 (S217/221), and p-CREB (S133). (B–F) Quantification of the relative expression for the ratio of BDNF/β-actin (B) , TrkB/β-actin (C) , p-MEK1/2 (S217/221)/total MEK1/2 (D) , p-ERK (T202/T204)/total ERK (E) , and p-CREB (S133)/total CREB (F) [F (3,15) = 19.35, p < 0.0001 for BDNF analysis; F (3,15) = 8.858, p = 0.0013 for TrkB analysis; F (3,15) = 10.38, p = 0.0006 for p-MEK (S217/221) analysis; F (3,15) = 45.21, p < 0.0001 for p-ERK (T202/T204) analysis; F (3,15) = 18.72, p < 0.0001 for p-CREB(S133) analysis]. Data are presented as mean ± S.E.M.

Journal: Frontiers in Pharmacology

Article Title: Niuhuang Qingxin Wan ameliorates depressive-like behaviors and improves hippocampal neurogenesis through modulating TrkB/ERK/CREB signaling pathway in chronic restraint stress or corticosterone challenge mice

doi: 10.3389/fphar.2023.1274343

Figure Lengend Snippet: NHQXW regulated the TrkB/ERK/CREB pathway in the hippocampus of CCS mice. The results were presented in 4 groups: vehicle-treated normal control group, CORT stress group, stress plus NQHXW treatment groups at a dosage of 20 mg/kg, and FLX treatment group. The sample size for all groups was 4-5. (A) Representative immunoblot results for the expression of BDNF, TrkB, p-ERK (T202/T204), p-MEK1/2 (S217/221), and p-CREB (S133). (B–F) Quantification of the relative expression for the ratio of BDNF/β-actin (B) , TrkB/β-actin (C) , p-MEK1/2 (S217/221)/total MEK1/2 (D) , p-ERK (T202/T204)/total ERK (E) , and p-CREB (S133)/total CREB (F) [F (3,15) = 19.35, p < 0.0001 for BDNF analysis; F (3,15) = 8.858, p = 0.0013 for TrkB analysis; F (3,15) = 10.38, p = 0.0006 for p-MEK (S217/221) analysis; F (3,15) = 45.21, p < 0.0001 for p-ERK (T202/T204) analysis; F (3,15) = 18.72, p < 0.0001 for p-CREB(S133) analysis]. Data are presented as mean ± S.E.M.

Article Snippet: The cells were co-treated with liquiritin and a TrkB selective inhibitor cyclotraxin B (Cyc-b, MCE) at a dosage of 100 nM.

Techniques: Control, Western Blot, Expressing

Diagram showing the neurogenic effects of NHQXW on NSCs through the TrkB/CREB pathway.

Journal: Frontiers in Pharmacology

doi: 10.3389/fphar.2023.1274343

Figure Lengend Snippet: Diagram showing the neurogenic effects of NHQXW on NSCs through the TrkB/CREB pathway.

Article Snippet: The cells were co-treated with liquiritin and a TrkB selective inhibitor cyclotraxin B (Cyc-b, MCE) at a dosage of 100 nM.

Techniques:

FIGURE 6 Single-dose injection of cyclotraxin-B into the insular cortex inhibited chronic corneal pain-induced chemical and mechanical corneal hypersensitivity. (A) Diagram and timeline schema of the experimental design. Gray arrows mark the local infusion of cyclotraxin-B or saline into the insular cortex. Bilateral extraorbital glands were excised on day 0. The insular cortex cannula was inserted on day 21 after surgery. Dark gray circles mark behavior test, including chemical and mechanical corneal sensitivity test. (B–E) Effect of treatment with single dose injection of BDNF antagonist cyclotraxin-B induces a statistically significant antinociceptive effect in chemical and mechanical corneal sensitivity. The DE + cyclotraxin-B group represents dry-eye mice receiving intra-insular cortical microinjection of cyclotraxin-B (10 and 0.05 μL per side; MCE) (n = 8, ***p < 0.001 and ****p < 0.0001 vs. DE + Saline group). CTB, cyclotraxin-B; DE, dry eye; ELG, extraorbital gland.

Journal: Genes, brain, and behavior

Article Title: Alteration of neural activity and neuroinflammatory factors in the insular cortex of mice with corneal neuropathic pain.

doi: 10.1111/gbb.12842

Figure Lengend Snippet: FIGURE 6 Single-dose injection of cyclotraxin-B into the insular cortex inhibited chronic corneal pain-induced chemical and mechanical corneal hypersensitivity. (A) Diagram and timeline schema of the experimental design. Gray arrows mark the local infusion of cyclotraxin-B or saline into the insular cortex. Bilateral extraorbital glands were excised on day 0. The insular cortex cannula was inserted on day 21 after surgery. Dark gray circles mark behavior test, including chemical and mechanical corneal sensitivity test. (B–E) Effect of treatment with single dose injection of BDNF antagonist cyclotraxin-B induces a statistically significant antinociceptive effect in chemical and mechanical corneal sensitivity. The DE + cyclotraxin-B group represents dry-eye mice receiving intra-insular cortical microinjection of cyclotraxin-B (10 and 0.05 μL per side; MCE) (n = 8, ***p < 0.001 and ****p < 0.0001 vs. DE + Saline group). CTB, cyclotraxin-B; DE, dry eye; ELG, extraorbital gland.

Article Snippet: The DE + cyclotraxin-B group represents dry-eye mice receiving intra-insular cortical microinjection of cyclotraxin-B (10 and 0.05 μL per side; MCE) (n = 8, ***p < 0.001 and ****p < 0.0001 vs. DE + Saline group).

Techniques: Injection, Saline, Microinjection

FIGURE 7 Continuous injection of cyclotraxin-B into the insular cortex reduced chronic corneal pain-induced corneal hypersensitivity and inhibited descending inflammatory factor upregulation. (A) Diagram and timeline schema of the experimental design. Gray arrows mark the local infusion of cyclotraxin-B or saline into the insular cortex. Bilateral extraorbital glands were excised on day 0. Insular cortex cannula was inserted on day 21 after surgery. Dark gray circles mark behavior test including chemical and mechanical corneal sensitivity test. Black circles mark open field test. Light gray circles mark tissue sampling with qRT-PCR. (B–E) The protein expression of TNFα, IL-6, IL-10, and IL-1β in DE mice after consecutive administration of cyclotraxin-B (10 μg/μL, 0.05 μL per side for 5 days) (n = 4, *p < 0.05 and **p < 0.01 vs. DE group). (F–L) Effect of treatment with BDNF antagonist cyclotraxin-B induces a statistically significant antinociceptive effect in chemical and mechanical corneal sensitivity, whereas during anxiolytic effect is unremarkable. The DE + cyclotraxin-B group represents that of dry eye mice receiving an intra- insular cortical microinjection of cyclotraxin-B (10 and 0.05 μL per side; MCE). (F–I) The chemical and mechanical thresholds after administration of cyclotraxin-B in DE mice (n = 8, **p < 0.01, ***p < 0.001 and ****p < 0.0001 vs. DE + saline group). (J) Representative activity tracking OFT in Sham, DE, DE + cyclotraxin-B, DE + saline mice. (K,L) Time in center region (K) and total distance traveled (L) during OFT (n = 6, ****p < 0.0001 vs. Sham group). CTB, cyclotraxin-B; DE, dry eye; IL-10, interleukin-10; IL-1β, interleukin-1β; IL-6, interleukin-6; NS, normal saline; ns, not significant; OFT, open field test; QPCR, quantitative polymerase chain reaction; TNFα, tumor necrosis factor α.

Journal: Genes, brain, and behavior

Article Title: Alteration of neural activity and neuroinflammatory factors in the insular cortex of mice with corneal neuropathic pain.

doi: 10.1111/gbb.12842

Figure Lengend Snippet: FIGURE 7 Continuous injection of cyclotraxin-B into the insular cortex reduced chronic corneal pain-induced corneal hypersensitivity and inhibited descending inflammatory factor upregulation. (A) Diagram and timeline schema of the experimental design. Gray arrows mark the local infusion of cyclotraxin-B or saline into the insular cortex. Bilateral extraorbital glands were excised on day 0. Insular cortex cannula was inserted on day 21 after surgery. Dark gray circles mark behavior test including chemical and mechanical corneal sensitivity test. Black circles mark open field test. Light gray circles mark tissue sampling with qRT-PCR. (B–E) The protein expression of TNFα, IL-6, IL-10, and IL-1β in DE mice after consecutive administration of cyclotraxin-B (10 μg/μL, 0.05 μL per side for 5 days) (n = 4, *p < 0.05 and **p < 0.01 vs. DE group). (F–L) Effect of treatment with BDNF antagonist cyclotraxin-B induces a statistically significant antinociceptive effect in chemical and mechanical corneal sensitivity, whereas during anxiolytic effect is unremarkable. The DE + cyclotraxin-B group represents that of dry eye mice receiving an intra- insular cortical microinjection of cyclotraxin-B (10 and 0.05 μL per side; MCE). (F–I) The chemical and mechanical thresholds after administration of cyclotraxin-B in DE mice (n = 8, **p < 0.01, ***p < 0.001 and ****p < 0.0001 vs. DE + saline group). (J) Representative activity tracking OFT in Sham, DE, DE + cyclotraxin-B, DE + saline mice. (K,L) Time in center region (K) and total distance traveled (L) during OFT (n = 6, ****p < 0.0001 vs. Sham group). CTB, cyclotraxin-B; DE, dry eye; IL-10, interleukin-10; IL-1β, interleukin-1β; IL-6, interleukin-6; NS, normal saline; ns, not significant; OFT, open field test; QPCR, quantitative polymerase chain reaction; TNFα, tumor necrosis factor α.

Techniques: Injection, Saline, Sampling, Quantitative RT-PCR, Expressing, Microinjection, Activity Assay, Real-time Polymerase Chain Reaction

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