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endogenous apelin receptor agonist pyr1 apelin 13  (MedChemExpress)


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    MedChemExpress endogenous apelin receptor agonist pyr1 apelin 13
    Endogenous Apelin Receptor Agonist Pyr1 Apelin 13, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-p1033/%5BPyr1%5D-Apelin-13/pm38175266-50-1-6
    Average 94 stars, based on 5 article reviews
    endogenous apelin receptor agonist pyr1 apelin 13 - by Bioz Stars, 2026-10
    94/100 stars

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    Related Articles

    other:

    Article Title: Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism.
    Article Snippet: Reagents for vitreous injection were taken from a study by Ishimaru et al. [21] and included [Pyr1]-apelin-13 (10 μg/eye, MedChemExpress; Shanghai, China) dissolved in sterile saline and LY294002 (5 nmol/eye, MedChemExpress; Shanghai, China) dissolved in sterile dimethyl sulfoxide (DMSO).

    Article Title: Single-cell transcriptomic analyses reveal angiogenic vascular responses to chronic cerebral hypoperfusion
    Article Snippet: [Pyr1]-Apelin-13 (Cat# HY-P1033, MedChemExpress, Monmouth Junction, NJ) was dissolved in PBS.

    Injection:

    Article Title: Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism
    Article Snippet: .. Reagents for vitreous injection were taken from a study by Ishimaru et al. [ ] and included [Pyr 1 ]-apelin-13 (10 μg/eye, MedChemExpress; Shanghai, China) dissolved in sterile saline and LY294002 (5 nmol/eye, MedChemExpress; Shanghai, China) dissolved in sterile dimethyl sulfoxide (DMSO). ..

    Sterility:

    Article Title: Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism
    Article Snippet: .. Reagents for vitreous injection were taken from a study by Ishimaru et al. [ ] and included [Pyr 1 ]-apelin-13 (10 μg/eye, MedChemExpress; Shanghai, China) dissolved in sterile saline and LY294002 (5 nmol/eye, MedChemExpress; Shanghai, China) dissolved in sterile dimethyl sulfoxide (DMSO). ..

    Saline:

    Article Title: Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism
    Article Snippet: .. Reagents for vitreous injection were taken from a study by Ishimaru et al. [ ] and included [Pyr 1 ]-apelin-13 (10 μg/eye, MedChemExpress; Shanghai, China) dissolved in sterile saline and LY294002 (5 nmol/eye, MedChemExpress; Shanghai, China) dissolved in sterile dimethyl sulfoxide (DMSO). ..



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    Apelin receptor agonists, [Pyr 1 <t>]apelin-13</t> and azelaprag inhibited cyst growth in 3D model of primary human ADPKD cells. (A) effect of [Pyr 1 ]apelin-13 on cyst volume, (B) effect of azelaprag on cyst volume, (C) effect of [Pyr 1 ]apelin-13 on cyst number, (D) effect of azelaprag on cyst number, (E) images of 3D cysts treated with apelin or azelaprag. N = 6 per group. Bar graphs represent mean±SEM.
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    Average 94 stars, based on 1 article reviews
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    Image Search Results


    Apelin receptor agonists, [Pyr 1 ]apelin-13 and azelaprag inhibited cyst growth in 3D model of primary human ADPKD cells. (A) effect of [Pyr 1 ]apelin-13 on cyst volume, (B) effect of azelaprag on cyst volume, (C) effect of [Pyr 1 ]apelin-13 on cyst number, (D) effect of azelaprag on cyst number, (E) images of 3D cysts treated with apelin or azelaprag. N = 6 per group. Bar graphs represent mean±SEM.

    Journal: bioRxiv

    Article Title: Apelin inhibits cyst growth and improves kidney function in mice with polycystic kidney disease

    doi: 10.64898/2026.03.26.714294

    Figure Lengend Snippet: Apelin receptor agonists, [Pyr 1 ]apelin-13 and azelaprag inhibited cyst growth in 3D model of primary human ADPKD cells. (A) effect of [Pyr 1 ]apelin-13 on cyst volume, (B) effect of azelaprag on cyst volume, (C) effect of [Pyr 1 ]apelin-13 on cyst number, (D) effect of azelaprag on cyst number, (E) images of 3D cysts treated with apelin or azelaprag. N = 6 per group. Bar graphs represent mean±SEM.

    Article Snippet: Mozavaptan (Cat. No.: HY-123593), [Pyr 1 ]apelin-13 (Cat No. HY-P1033), and azelaprag (Cat. No. HY-109111) were obtained from MedChemExpress (Monmouth Junction, New Jersey, USA).

    Techniques:

    Effects of exogenous apelin receptor agonist, [Pyr 1 ]apelin-13 or azelaprag on cyst growth in mice. (A) representative histological images of kidneys, (B) percent two kidney weight to body weight ratio (%2KW/BW), (C) percent cystic index, (D) cyst number, (E) blood urea nitrogen (BUN), (F) percent heart weight to body weight (%HW/BW). Phenotypic normal (noncystic), n=6; vehicle or azelaprag, n=13/group, mozavaptan or [Pyr 1 ]apelin-13, n=10/group. Open cycles represent female animals. Bar graphs represent mean±SEM.

    Journal: bioRxiv

    Article Title: Apelin inhibits cyst growth and improves kidney function in mice with polycystic kidney disease

    doi: 10.64898/2026.03.26.714294

    Figure Lengend Snippet: Effects of exogenous apelin receptor agonist, [Pyr 1 ]apelin-13 or azelaprag on cyst growth in mice. (A) representative histological images of kidneys, (B) percent two kidney weight to body weight ratio (%2KW/BW), (C) percent cystic index, (D) cyst number, (E) blood urea nitrogen (BUN), (F) percent heart weight to body weight (%HW/BW). Phenotypic normal (noncystic), n=6; vehicle or azelaprag, n=13/group, mozavaptan or [Pyr 1 ]apelin-13, n=10/group. Open cycles represent female animals. Bar graphs represent mean±SEM.

    Article Snippet: Mozavaptan (Cat. No.: HY-123593), [Pyr 1 ]apelin-13 (Cat No. HY-P1033), and azelaprag (Cat. No. HY-109111) were obtained from MedChemExpress (Monmouth Junction, New Jersey, USA).

    Techniques:

    [Pyr 1 ]apelin-13 inhibited cAMP production and ERK1/2 signaling in cystic kidneys. (A) kidney cAMP concentration, (B) phosphorylated ERK1/2/total (pERK1/2) relative to total ERK1/2 and a representative western blot image (right panel). Noncystic, n=6; Vehicle (n=7 for WB) or azelaprag, n=13 each, mozavaptan or [Pyr 1 ]apelin-13, n=10 each. For western blot: noncystic (n = 3); vehicle, (n = 7), azelaprag (n = 7), mozavaptan (n = 8), [Pyr 1 ]apelin-13 (n = 7). Bar graphs represent mean±SEM.

    Journal: bioRxiv

    Article Title: Apelin inhibits cyst growth and improves kidney function in mice with polycystic kidney disease

    doi: 10.64898/2026.03.26.714294

    Figure Lengend Snippet: [Pyr 1 ]apelin-13 inhibited cAMP production and ERK1/2 signaling in cystic kidneys. (A) kidney cAMP concentration, (B) phosphorylated ERK1/2/total (pERK1/2) relative to total ERK1/2 and a representative western blot image (right panel). Noncystic, n=6; Vehicle (n=7 for WB) or azelaprag, n=13 each, mozavaptan or [Pyr 1 ]apelin-13, n=10 each. For western blot: noncystic (n = 3); vehicle, (n = 7), azelaprag (n = 7), mozavaptan (n = 8), [Pyr 1 ]apelin-13 (n = 7). Bar graphs represent mean±SEM.

    Article Snippet: Mozavaptan (Cat. No.: HY-123593), [Pyr 1 ]apelin-13 (Cat No. HY-P1033), and azelaprag (Cat. No. HY-109111) were obtained from MedChemExpress (Monmouth Junction, New Jersey, USA).

    Techniques: Concentration Assay, Western Blot

    Effect of exogenous [Pyr 1 ]apelin-13 treatment on inflammation and RAS pathway in the kidneys. A, Ccl2 , B, Tnfα , C, Il1β , D, Ace , E, Ace2, F. Ace/Ace2 ratio. Noncystic, n = 6; Vehicle (n = 7 for WB) or Azelaprag, n = 13 each, Mozavaptan or [Pyr 1 ]apelin-13, n = 10 each.

    Journal: bioRxiv

    Article Title: Apelin inhibits cyst growth and improves kidney function in mice with polycystic kidney disease

    doi: 10.64898/2026.03.26.714294

    Figure Lengend Snippet: Effect of exogenous [Pyr 1 ]apelin-13 treatment on inflammation and RAS pathway in the kidneys. A, Ccl2 , B, Tnfα , C, Il1β , D, Ace , E, Ace2, F. Ace/Ace2 ratio. Noncystic, n = 6; Vehicle (n = 7 for WB) or Azelaprag, n = 13 each, Mozavaptan or [Pyr 1 ]apelin-13, n = 10 each.

    Article Snippet: Mozavaptan (Cat. No.: HY-123593), [Pyr 1 ]apelin-13 (Cat No. HY-P1033), and azelaprag (Cat. No. HY-109111) were obtained from MedChemExpress (Monmouth Junction, New Jersey, USA).

    Techniques:

    Differentially expressed genes between vehicle- and apelin-treated PKD mice. (A) volcano plot of differentially expressed genes in apelin-treated relative to vehicle-treated mice, (B) dot plot showing top enriched biological process pathways in gene ontology that were upregulated by Pyr ]apelin-13 treatment compared to vehicle, (C) dot plot showing top enriched biological process pathways in gene ontology that were downregulated by Pyr ]apelin-13 treatment compared to vehicle. N = 3 samples per group.

    Journal: bioRxiv

    Article Title: Apelin inhibits cyst growth and improves kidney function in mice with polycystic kidney disease

    doi: 10.64898/2026.03.26.714294

    Figure Lengend Snippet: Differentially expressed genes between vehicle- and apelin-treated PKD mice. (A) volcano plot of differentially expressed genes in apelin-treated relative to vehicle-treated mice, (B) dot plot showing top enriched biological process pathways in gene ontology that were upregulated by Pyr ]apelin-13 treatment compared to vehicle, (C) dot plot showing top enriched biological process pathways in gene ontology that were downregulated by Pyr ]apelin-13 treatment compared to vehicle. N = 3 samples per group.

    Article Snippet: Mozavaptan (Cat. No.: HY-123593), [Pyr 1 ]apelin-13 (Cat No. HY-P1033), and azelaprag (Cat. No. HY-109111) were obtained from MedChemExpress (Monmouth Junction, New Jersey, USA).

    Techniques:

    pPCR validation of differentially downregulated (A-B) or upregulated (C-D) genes identified from bulk RNAseq data. (A) Timp1 , (B) Mmp14 , (C) Dio1, and (D) Acaab1 . Noncystic, n = 6; Vehicle or azelaprag, n = 13 each, mozavaptan or [Pyr 1 ]apelin-13, n = 10 each.

    Journal: bioRxiv

    Article Title: Apelin inhibits cyst growth and improves kidney function in mice with polycystic kidney disease

    doi: 10.64898/2026.03.26.714294

    Figure Lengend Snippet: pPCR validation of differentially downregulated (A-B) or upregulated (C-D) genes identified from bulk RNAseq data. (A) Timp1 , (B) Mmp14 , (C) Dio1, and (D) Acaab1 . Noncystic, n = 6; Vehicle or azelaprag, n = 13 each, mozavaptan or [Pyr 1 ]apelin-13, n = 10 each.

    Article Snippet: Mozavaptan (Cat. No.: HY-123593), [Pyr 1 ]apelin-13 (Cat No. HY-P1033), and azelaprag (Cat. No. HY-109111) were obtained from MedChemExpress (Monmouth Junction, New Jersey, USA).

    Techniques: Biomarker Discovery, RNA sequencing

    [Pyr 1 ]apelin-13 did not promote diuresis or urine osmolality in wildtype mice. Urine volume for: (A) [Pyr 1 ]apelin-13, (B) azelaprag, (C) mozavaptan; Urine osmolality for: (D) [Pyr 1 ]apelin-13, (E) azelaprag, (F) mozavaptan. 0.9% saline was used as vehicle for [Pyr 1 ]apelin-13 and azelaprag while vehicle for mozavaptan was water. N = 6. Bar graphs represent mean±SEM.

    Journal: bioRxiv

    Article Title: Apelin inhibits cyst growth and improves kidney function in mice with polycystic kidney disease

    doi: 10.64898/2026.03.26.714294

    Figure Lengend Snippet: [Pyr 1 ]apelin-13 did not promote diuresis or urine osmolality in wildtype mice. Urine volume for: (A) [Pyr 1 ]apelin-13, (B) azelaprag, (C) mozavaptan; Urine osmolality for: (D) [Pyr 1 ]apelin-13, (E) azelaprag, (F) mozavaptan. 0.9% saline was used as vehicle for [Pyr 1 ]apelin-13 and azelaprag while vehicle for mozavaptan was water. N = 6. Bar graphs represent mean±SEM.

    Article Snippet: Mozavaptan (Cat. No.: HY-123593), [Pyr 1 ]apelin-13 (Cat No. HY-P1033), and azelaprag (Cat. No. HY-109111) were obtained from MedChemExpress (Monmouth Junction, New Jersey, USA).

    Techniques: Saline