nts (MedChemExpress)
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MedChemExpress
nts
Nts, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p0234/Neurotensin/pm38071436-16-0-6
Average 94 stars, based on 8 article reviews
Nts, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p0234/Neurotensin/pm38071436-16-0-6
Average 94 stars, based on 8 article reviews
nts - by Bioz Stars,
2026-10
94/100 stars
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Injection:Article Title: The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory. Article Snippet: Microtubule-associated Protein 6 (MAP6) is critical for maintaining microtubule stability and synaptic plasticity, and its dysfunction is a key driver of cognitive impairment.. However, the molecular mechanisms linking MAP6 deletion to cognitive deficits remain unclear.. Here, we generated a novel Map6 knockout (KO, Map6 /− ) mouse model using CRISPR/Cas9-mediated genome editing. In Vivo:Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll In Vitro:Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll Antibody Labeling:Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll Magnetic Beads:Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll Protease Inhibitor:Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll Reverse Transcription:Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll Recombinant:Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll Concentration Assay:Article Title: Molecular recognition of thyroglobulin by sortilin. Article Snippet: .. The complex was then perturbated with the addition of Article Title: The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory. Article Snippet: Microtubule-associated Protein 6 (MAP6) is critical for maintaining microtubule stability and synaptic plasticity, and its dysfunction is a key driver of cognitive impairment.. However, the molecular mechanisms linking MAP6 deletion to cognitive deficits remain unclear.. Here, we generated a novel Map6 knockout (KO, Map6 /− ) mouse model using CRISPR/Cas9-mediated genome editing. Titration:Article Title: Molecular recognition of thyroglobulin by sortilin. Article Snippet: .. The complex was then perturbated with the addition of Sequencing:Article Title: Copper-Mediated Cross-Coupling Selective for Pyroglutamate Post-Translational Modifications. Article Snippet: .. A list of commercial peptides used in this study. peptide (number) (sequence) supplier (catalog no) xenopsin (12) (pEGKRPWIL-OH) MCE (HY-P0253) teprotide (13) (pEWPRPQIPP-OH) MCE (HY-P2366) bradykinin potentiator B (14) ( High Performance Liquid Chromatography:Article Title: Copper-Mediated Cross-Coupling Selective for Pyroglutamate Post-Translational Modifications. Article Snippet: .. A list of commercial peptides used in this study. peptide (number) (sequence) supplier (catalog no) xenopsin (12) (pEGKRPWIL-OH) MCE (HY-P0253) teprotide (13) (pEWPRPQIPP-OH) MCE (HY-P2366) bradykinin potentiator B (14) ( Sterility:Article Title: The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory. Article Snippet: Microtubule-associated Protein 6 (MAP6) is critical for maintaining microtubule stability and synaptic plasticity, and its dysfunction is a key driver of cognitive impairment.. However, the molecular mechanisms linking MAP6 deletion to cognitive deficits remain unclear.. Here, we generated a novel Map6 knockout (KO, Map6 /− ) mouse model using CRISPR/Cas9-mediated genome editing. Saline:Article Title: The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory. Article Snippet: Microtubule-associated Protein 6 (MAP6) is critical for maintaining microtubule stability and synaptic plasticity, and its dysfunction is a key driver of cognitive impairment.. However, the molecular mechanisms linking MAP6 deletion to cognitive deficits remain unclear.. Here, we generated a novel Map6 knockout (KO, Map6 /− ) mouse model using CRISPR/Cas9-mediated genome editing. Negative Control:Article Title: The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory. Article Snippet: Microtubule-associated Protein 6 (MAP6) is critical for maintaining microtubule stability and synaptic plasticity, and its dysfunction is a key driver of cognitive impairment.. However, the molecular mechanisms linking MAP6 deletion to cognitive deficits remain unclear.. Here, we generated a novel Map6 knockout (KO, Map6 /− ) mouse model using CRISPR/Cas9-mediated genome editing. |