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ara290 (MedChemExpress)

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MedChemExpress ara290
Ara290, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p0168/Cibinetide/pm32335150-53-0-4
Average 93 stars, based on 7 article reviews

ara290 - by Bioz Stars, 2026-10

93/100 stars

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Article Title: EPOR activation attenuates colitis via enhancing LC3B-dependent apoptotic cell clearance.
Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Number: 82071209; Jiangsu Provincial Key Research and Development Program, Grant/Award Number: BE2022673 Abstract Systemic immune activation and excessive inflammatory response, induced by intestinal barrier damage, are the major characteristics of inflammatory bowel disease (IBD).. Excessive apoptotic cell accumulation leads to the production of a large number of inflammatory factors, further aggravating IBD development.. Gene set enrichment analysis data showed that the homodimeric erythropoietin receptor (EPOR) was highly expressed in the whole blood of patients with IBD.

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Article Title: The Role of Macrophage Efferocytosis in the Pathogenesis of Apical Periodontitis
Article Snippet: .. Following the pulp operation, ARA290 (120 μg/kg, MCE, Monmouth Junction, NJ, USA) was intraperitoneally injected into mice three times per week [ ]. ..

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ARA290 inhibited the progression of apical periodontitis by restraining osteoclast differentiation. A, The body weight of mice in the AP and ARA290 groups. B, The representative radiographs of the mandible first molar of the experiment apical periodontitis in the AP and ARA290 groups. The images were taken using a three-dimensional micro-CT at three different views: coronal, sagittal and axial. C, The quantification of bone resorption volumes in the AP and ARA290 groups. The representative images of haematoxylin and eosin (D), Masson (E) and TRAP (F) staining show that bone resorption and osteoclasts infiltration in the AP and ARA290 groups. (Scale bar: the upper = 200 μm, the lower = 50 μm.) G, Immunohistochemical staining (scale bar = 50 μm) of RANKL and OPG in the AP and ARA290 groups. The quantification of RANKL (H), OPG (I) and the ratio of RANKL/OPG (J) in the AP and ARA290 groups. The red arrows represent cells with positive staining in the pathological staining figures; *** P < .005. AP, apical periodontitis; ARA290, apical periodontitis with the treatment of ARA290.

Journal: International Dental Journal

Article Title: ARA290 Attenuates Apical Periodontitis via SIRT1/NF-κB/IL-1β Pathway Modulation

doi: 10.1016/j.identj.2025.100863

Figure Lengend Snippet: ARA290 inhibited the progression of apical periodontitis by restraining osteoclast differentiation. A, The body weight of mice in the AP and ARA290 groups. B, The representative radiographs of the mandible first molar of the experiment apical periodontitis in the AP and ARA290 groups. The images were taken using a three-dimensional micro-CT at three different views: coronal, sagittal and axial. C, The quantification of bone resorption volumes in the AP and ARA290 groups. The representative images of haematoxylin and eosin (D), Masson (E) and TRAP (F) staining show that bone resorption and osteoclasts infiltration in the AP and ARA290 groups. (Scale bar: the upper = 200 μm, the lower = 50 μm.) G, Immunohistochemical staining (scale bar = 50 μm) of RANKL and OPG in the AP and ARA290 groups. The quantification of RANKL (H), OPG (I) and the ratio of RANKL/OPG (J) in the AP and ARA290 groups. The red arrows represent cells with positive staining in the pathological staining figures; *** P < .005. AP, apical periodontitis; ARA290, apical periodontitis with the treatment of ARA290.

Article Snippet: Following the pulp procedure, ARA290 (120 μg/kg, MCE) was administered intraperitoneally to mice thrice weekly.

Techniques: Micro-CT, Staining, Immunohistochemical staining

SIRT1/NF-κB/IL-1β signalling pathway was the potential target pathway for ARA290 to regulate the apical periodontitis course. A, Venn diagram of 17 intersecting target proteins from ARA290 and AP. B, The PPI network of intersecting target proteins from ARA290 and AP. C, KEGG pathway analysis of ARA290 in treating apical periodontitis. D, Immunohistochemical staining (scale bar = 50 μm) of SIRT1, acetylated NF-κB and IL-1β in the AP and ARA290 groups. E, The quantification of SIRT1, acetylated NF-κB and IL-1β (F) SIRT1-CD68 double labelling (scale bar = 50 μm) in the AP and ARA290 groups. Green, SIRT1; red, CD68; blue, DAPI. The red arrows represent cells with positive staining in the pathological staining figures; * P < .05, *** P < .005. AP, apical periodontitis; ARA290, apical periodontitis with the treatment of ARA290.

Journal: International Dental Journal

Article Title: ARA290 Attenuates Apical Periodontitis via SIRT1/NF-κB/IL-1β Pathway Modulation

doi: 10.1016/j.identj.2025.100863

Figure Lengend Snippet: SIRT1/NF-κB/IL-1β signalling pathway was the potential target pathway for ARA290 to regulate the apical periodontitis course. A, Venn diagram of 17 intersecting target proteins from ARA290 and AP. B, The PPI network of intersecting target proteins from ARA290 and AP. C, KEGG pathway analysis of ARA290 in treating apical periodontitis. D, Immunohistochemical staining (scale bar = 50 μm) of SIRT1, acetylated NF-κB and IL-1β in the AP and ARA290 groups. E, The quantification of SIRT1, acetylated NF-κB and IL-1β (F) SIRT1-CD68 double labelling (scale bar = 50 μm) in the AP and ARA290 groups. Green, SIRT1; red, CD68; blue, DAPI. The red arrows represent cells with positive staining in the pathological staining figures; * P < .05, *** P < .005. AP, apical periodontitis; ARA290, apical periodontitis with the treatment of ARA290.

Article Snippet: Following the pulp procedure, ARA290 (120 μg/kg, MCE) was administered intraperitoneally to mice thrice weekly.

Techniques: Immunohistochemical staining, Staining

Inhibition of SIRT1 significantly blocked the role of ARA290 in in vitro apical periodontitis models. A, immunofluorescence staining of SIRT1, acetylated NF-κB and IL-1β in each group. Red fluorescence: target protein; blue fluorescence: DAPI. (Scale bar = 20 μm.) B, Representative images of western blots of SIRT1 and acetylated NF-κB in each group. C, The quantification of SIRT1 and acetylated NF-κB. D, The expression of IL-1β in each group via RT-qPCR. ns P > .05, * P < .05, *** P < .005. selisistat: the inhibitor of SIRT1.

Journal: International Dental Journal

Article Title: ARA290 Attenuates Apical Periodontitis via SIRT1/NF-κB/IL-1β Pathway Modulation

doi: 10.1016/j.identj.2025.100863

Figure Lengend Snippet: Inhibition of SIRT1 significantly blocked the role of ARA290 in in vitro apical periodontitis models. A, immunofluorescence staining of SIRT1, acetylated NF-κB and IL-1β in each group. Red fluorescence: target protein; blue fluorescence: DAPI. (Scale bar = 20 μm.) B, Representative images of western blots of SIRT1 and acetylated NF-κB in each group. C, The quantification of SIRT1 and acetylated NF-κB. D, The expression of IL-1β in each group via RT-qPCR. ns P > .05, * P < .05, *** P < .005. selisistat: the inhibitor of SIRT1.

Article Snippet: Following the pulp procedure, ARA290 (120 μg/kg, MCE) was administered intraperitoneally to mice thrice weekly.

Techniques: Inhibition, In Vitro, Immunofluorescence, Staining, Fluorescence, Western Blot, Expressing, Quantitative RT-PCR

Graphic abstract of the current research. A, In the progression of apical periodontitis, the pathogen-induced macrophage osteoclast differentiation via regulating SIRT1/NF-κB/IL-1β signalling pathway in Mф, which promoted the destruction of periapical bone tissues. B, The treatment of ARA290 could suppress the osteoclast differentiation via SIRT1/NF-κB/IL-1β in Mф, limiting the progression of apical periodontitis. The red arrow, activation; the green arrow, inhibition.

Journal: International Dental Journal

Article Title: ARA290 Attenuates Apical Periodontitis via SIRT1/NF-κB/IL-1β Pathway Modulation

doi: 10.1016/j.identj.2025.100863

Figure Lengend Snippet: Graphic abstract of the current research. A, In the progression of apical periodontitis, the pathogen-induced macrophage osteoclast differentiation via regulating SIRT1/NF-κB/IL-1β signalling pathway in Mф, which promoted the destruction of periapical bone tissues. B, The treatment of ARA290 could suppress the osteoclast differentiation via SIRT1/NF-κB/IL-1β in Mф, limiting the progression of apical periodontitis. The red arrow, activation; the green arrow, inhibition.

Article Snippet: Following the pulp procedure, ARA290 (120 μg/kg, MCE) was administered intraperitoneally to mice thrice weekly.

Techniques: Activation Assay, Inhibition

ARA290 exerts a similar neuroprotective effect as erythropoietin (EPO) in cerebral ischemic mice. (A) Representative coronal sections stained with 2, 3, 5‐triphenyl‐tetrazolium chloride (TTC), showing the size of the infarction volume; (B) Schematic diagram of the percentage of brain infarction in different groups at 7 days after middle cerebral artery occlusion (MCAO). ARA290 was injected intraperitoneally (i.p.) at the beginning of reperfusion after the MCAO surgery. 30, qd: administered with ARA290 at doses of 30 μg/kg once daily; 30, bid: administered with ARA290 at doses of 30 μg/kg twice daily; 100, qd: administered with ARA290 at doses of 100 μg/kg once daily. Data are presented as mean ± SEM, n = 8–9 per group. ** p < 0.01, 30 bid group vs. MCAO group. (C) Representative coronal sections stained with TTC, and (D) a schematic diagram illustrating the percentage of brain infarction in different groups at 7 days after MCAO. Data are presented as mean ± SEM, n = 5–6 per group. * p < 0.05, EPO group vs. MCAO group; *** p < 0.001, ARA290 group vs. MCAO group. (E) Representative coronal sections and (F) a schematic diagram of the percentage of brain tissue loss in the different groups 14 days after MCAO. Data are presented as mean ± SEM, n = 6–7 per group. * p < 0.05, EPO group vs. MCAO group; * p < 0.05, ARA290 group vs. MCAO group. (G) Body weight in different groups after MCAO. (H, I) Longa test and modified neurological severity scores were evaluated in different groups. Data are presented as mean ± SEM, n = 9–10 per group. *** p < 0.001, EPO group vs. MCAO group; ** p < 0.01, ARA290 group vs. MCAO group; *** p < 0.001, ARA290 group vs. MCAO group.

Journal: CNS Neuroscience & Therapeutics

Article Title: Erythropoietin‐derived peptide ARA290 mediates brain tissue protection through the β‐common receptor in mice with cerebral ischemic stroke

doi: 10.1111/cns.14676

Figure Lengend Snippet: ARA290 exerts a similar neuroprotective effect as erythropoietin (EPO) in cerebral ischemic mice. (A) Representative coronal sections stained with 2, 3, 5‐triphenyl‐tetrazolium chloride (TTC), showing the size of the infarction volume; (B) Schematic diagram of the percentage of brain infarction in different groups at 7 days after middle cerebral artery occlusion (MCAO). ARA290 was injected intraperitoneally (i.p.) at the beginning of reperfusion after the MCAO surgery. 30, qd: administered with ARA290 at doses of 30 μg/kg once daily; 30, bid: administered with ARA290 at doses of 30 μg/kg twice daily; 100, qd: administered with ARA290 at doses of 100 μg/kg once daily. Data are presented as mean ± SEM, n = 8–9 per group. ** p < 0.01, 30 bid group vs. MCAO group. (C) Representative coronal sections stained with TTC, and (D) a schematic diagram illustrating the percentage of brain infarction in different groups at 7 days after MCAO. Data are presented as mean ± SEM, n = 5–6 per group. * p < 0.05, EPO group vs. MCAO group; *** p < 0.001, ARA290 group vs. MCAO group. (E) Representative coronal sections and (F) a schematic diagram of the percentage of brain tissue loss in the different groups 14 days after MCAO. Data are presented as mean ± SEM, n = 6–7 per group. * p < 0.05, EPO group vs. MCAO group; * p < 0.05, ARA290 group vs. MCAO group. (G) Body weight in different groups after MCAO. (H, I) Longa test and modified neurological severity scores were evaluated in different groups. Data are presented as mean ± SEM, n = 9–10 per group. *** p < 0.001, EPO group vs. MCAO group; ** p < 0.01, ARA290 group vs. MCAO group; *** p < 0.001, ARA290 group vs. MCAO group.

Article Snippet: ARA290 (Cibinetide) was obtained from MedChem Express (Cat No: HY‐P0168, USA).

Techniques: Staining, Injection, Modification

ARA290 attenuates neuronal apoptosis and inflammation in the per‐infarct region after cerebral ischemia. (A) Photomicrographs displaying terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) (red) and NeuN (green) double‐positive cells in the peripheral area of brain infarction in different groups 7 days after middle cerebral artery occlusion (MCAO). DAPI (blue) indicates the cell nuclei. Scale bar, 50 μm. (B) Quantification of TUNEL + /NeuN + colabeling cells in different groups. Data are presented as mean ± SEM, n = 6 per group. * p < 0.05, ARA290 group vs. MCAO group. The quantification of TNF‐α (C), IL‐1β (D), and IL‐6 (E) expression in the Sham, MCAO, and ARA290 treatment mouse brain at 1 and 7 days post‐MCAO. Data are presented as mean ± SEM, n = 4–9 per group. *** p < 0.001, MCAO group vs. Sham group; # p < 0.05, ## p < 0.01, ### p < 0.001, ARA290 group vs. MCAO group.

Journal: CNS Neuroscience & Therapeutics

Article Title: Erythropoietin‐derived peptide ARA290 mediates brain tissue protection through the β‐common receptor in mice with cerebral ischemic stroke

doi: 10.1111/cns.14676

Figure Lengend Snippet: ARA290 attenuates neuronal apoptosis and inflammation in the per‐infarct region after cerebral ischemia. (A) Photomicrographs displaying terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) (red) and NeuN (green) double‐positive cells in the peripheral area of brain infarction in different groups 7 days after middle cerebral artery occlusion (MCAO). DAPI (blue) indicates the cell nuclei. Scale bar, 50 μm. (B) Quantification of TUNEL + /NeuN + colabeling cells in different groups. Data are presented as mean ± SEM, n = 6 per group. * p < 0.05, ARA290 group vs. MCAO group. The quantification of TNF‐α (C), IL‐1β (D), and IL‐6 (E) expression in the Sham, MCAO, and ARA290 treatment mouse brain at 1 and 7 days post‐MCAO. Data are presented as mean ± SEM, n = 4–9 per group. *** p < 0.001, MCAO group vs. Sham group; # p < 0.05, ## p < 0.01, ### p < 0.001, ARA290 group vs. MCAO group.

Article Snippet: ARA290 (Cibinetide) was obtained from MedChem Express (Cat No: HY‐P0168, USA).

Techniques: TUNEL Assay, Expressing

ARA290 produces a metabolomic signature in middle cerebral artery occlusion (MCAO) mice. (A) Principal Component Analysis (PCA) scores among the Sham, MCAO, and ARA290 groups. (B) Volcano plots display all metabolite alterations in the plasma of mice between groups. (C) Metabolic pathway enrichment analysis of differential metabolites in the plasma of mice, n = 5 per group. All matched pathways are displayed as circles; the colors of the circles are based on the pathways' p ‐value, and the size is based on the impact value. Redder and larger circles indicate lower p ‐values and greater count numbers.

Journal: CNS Neuroscience & Therapeutics

Article Title: Erythropoietin‐derived peptide ARA290 mediates brain tissue protection through the β‐common receptor in mice with cerebral ischemic stroke

doi: 10.1111/cns.14676

Figure Lengend Snippet: ARA290 produces a metabolomic signature in middle cerebral artery occlusion (MCAO) mice. (A) Principal Component Analysis (PCA) scores among the Sham, MCAO, and ARA290 groups. (B) Volcano plots display all metabolite alterations in the plasma of mice between groups. (C) Metabolic pathway enrichment analysis of differential metabolites in the plasma of mice, n = 5 per group. All matched pathways are displayed as circles; the colors of the circles are based on the pathways' p ‐value, and the size is based on the impact value. Redder and larger circles indicate lower p ‐values and greater count numbers.

Article Snippet: ARA290 (Cibinetide) was obtained from MedChem Express (Cat No: HY‐P0168, USA).

Techniques:

ARA290 abolishes the erythropoietic activity of erythropoietin (EPO) without potential safety issues. (A) Respective representative photographs of spleens from different groups 7 days after middle cerebral artery occlusion (MCAO) surgery. Histograms showing the spleen's weight (B) and length (C) in different groups. Data are presented as mean ± SEM, n = 5–7 per group. * p < 0.05, ** p < 0.01, MCAO group vs. Sham group; ** p < 0.05, EPO group vs. Sham group; ### p < 0.001, EPO group vs. MCAO group; +++ p < 0.001, ARA290 group vs. EPO group. Quantification of the blood parameters of RBC (D), HGB (E), PLT (F), HCT (G), RDW‐CV (H), RDW‐SD (I), and MCV (J) from different groups 7 days after MCAO surgery. Data are presented as mean ± SEM, n = 5 per group. * p < 0.05, ** p < 0.01, *** p < 0.001, EPO group vs. Sham group; ## p < 0.01, ### p < 0.001, ARA290 group vs. EPO group. HCT, hematocrit; HGB, hemoglobin; MCV, mean corpuscular volume; PLT, platelet; RBC, red blood cell; RDW‐CV, coefficient variation of red blood cell volume distribution width; RDW‐SD, standard deviation in red cell distribution width. (K–M) The serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels were determined by commercial reagent kits 14 days after MCAO surgery. Data are presented as mean ± SEM, n = 8–9 per group.

Journal: CNS Neuroscience & Therapeutics

Article Title: Erythropoietin‐derived peptide ARA290 mediates brain tissue protection through the β‐common receptor in mice with cerebral ischemic stroke

doi: 10.1111/cns.14676

Figure Lengend Snippet: ARA290 abolishes the erythropoietic activity of erythropoietin (EPO) without potential safety issues. (A) Respective representative photographs of spleens from different groups 7 days after middle cerebral artery occlusion (MCAO) surgery. Histograms showing the spleen's weight (B) and length (C) in different groups. Data are presented as mean ± SEM, n = 5–7 per group. * p < 0.05, ** p < 0.01, MCAO group vs. Sham group; ** p < 0.05, EPO group vs. Sham group; ### p < 0.001, EPO group vs. MCAO group; +++ p < 0.001, ARA290 group vs. EPO group. Quantification of the blood parameters of RBC (D), HGB (E), PLT (F), HCT (G), RDW‐CV (H), RDW‐SD (I), and MCV (J) from different groups 7 days after MCAO surgery. Data are presented as mean ± SEM, n = 5 per group. * p < 0.05, ** p < 0.01, *** p < 0.001, EPO group vs. Sham group; ## p < 0.01, ### p < 0.001, ARA290 group vs. EPO group. HCT, hematocrit; HGB, hemoglobin; MCV, mean corpuscular volume; PLT, platelet; RBC, red blood cell; RDW‐CV, coefficient variation of red blood cell volume distribution width; RDW‐SD, standard deviation in red cell distribution width. (K–M) The serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels were determined by commercial reagent kits 14 days after MCAO surgery. Data are presented as mean ± SEM, n = 8–9 per group.

Article Snippet: ARA290 (Cibinetide) was obtained from MedChem Express (Cat No: HY‐P0168, USA).

Techniques: Activity Assay, Standard Deviation

β‐Common receptor (βCR) is essential in the neuroprotective effect of ARA290 against cerebral ischemic stroke. (A) Western blot analysis shows the efficiency of βCR siRNA on the expression of βCR in brain tissue 1 day after middle cerebral artery occlusion (MCAO) surgery. β‐Actin was used as a control to normalize protein expression. Data are presented as mean ± SEM, n = 4 per group. *** p < 0.001, MCAO + βCR siRNA group vs. MCAO + negative control (NC) group. (B) Representative coronal sections stained with 2, 3, 5‐triphenyltetrazolium chloride (TTC) and (C) a schematic diagram of the percentage of brain infarction in the different groups 7 days after MCAO. Data are presented as mean ± SEM, n = 8 per group. * p < 0.05, ARA290 + NC group vs. MCAO + NC group; # p < 0.05, ARA290 + βCR siRNA group vs. ARA290 + NC group. (D) Representative coronal sections and (E) schematic diagram of the percentage of brain tissue loss in the different groups 14 days after MCAO. Data are presented as mean ± SEM, n = 4–5 per group. * p < 0.05, erythropoietin (EPO) + NC group vs. MCAO + NC group.

Journal: CNS Neuroscience & Therapeutics

Article Title: Erythropoietin‐derived peptide ARA290 mediates brain tissue protection through the β‐common receptor in mice with cerebral ischemic stroke

doi: 10.1111/cns.14676

Figure Lengend Snippet: β‐Common receptor (βCR) is essential in the neuroprotective effect of ARA290 against cerebral ischemic stroke. (A) Western blot analysis shows the efficiency of βCR siRNA on the expression of βCR in brain tissue 1 day after middle cerebral artery occlusion (MCAO) surgery. β‐Actin was used as a control to normalize protein expression. Data are presented as mean ± SEM, n = 4 per group. *** p < 0.001, MCAO + βCR siRNA group vs. MCAO + negative control (NC) group. (B) Representative coronal sections stained with 2, 3, 5‐triphenyltetrazolium chloride (TTC) and (C) a schematic diagram of the percentage of brain infarction in the different groups 7 days after MCAO. Data are presented as mean ± SEM, n = 8 per group. * p < 0.05, ARA290 + NC group vs. MCAO + NC group; # p < 0.05, ARA290 + βCR siRNA group vs. ARA290 + NC group. (D) Representative coronal sections and (E) schematic diagram of the percentage of brain tissue loss in the different groups 14 days after MCAO. Data are presented as mean ± SEM, n = 4–5 per group. * p < 0.05, erythropoietin (EPO) + NC group vs. MCAO + NC group.

Article Snippet: ARA290 (Cibinetide) was obtained from MedChem Express (Cat No: HY‐P0168, USA).

Techniques: Western Blot, Expressing, Control, Negative Control, Staining

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ara290 (MedChemExpress)

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