thymosin α1 (MedChemExpress)
Structured Review
Thymosin α1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-p0091/Thymalfasin/pm41619634-54-22-25
Average 94 stars, based on 5 article reviews
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Flow Cytometry:Article Title: Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma Article Snippet: BxPC-3 cells were cultured in RPMI-1640 medium supplemented with 10% (v/v) FBS and penicillin‒streptomycin at 37 °C in a cell incubator with 5% CO2, and PANC-1 and MIA PaCa-2 cells were cultured in DMEM (Cat# C11965500BT, Thermo Fisher Scientific) supplemented with 10% (v/v) FBS and penicillin‒streptomycin at 37 °C in a cell incubator with 5% CO2. .. Flow cytometry analysis of PD-1 levels on CD8+ T cells After being treated with IFN-α (Cat# HY-P7023, MCE, USA), Isolation:Article Title: Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma Article Snippet: BxPC-3 cells were cultured in RPMI-1640 medium supplemented with 10% (v/v) FBS and penicillin‒streptomycin at 37 °C in a cell incubator with 5% CO2, and PANC-1 and MIA PaCa-2 cells were cultured in DMEM (Cat# C11965500BT, Thermo Fisher Scientific) supplemented with 10% (v/v) FBS and penicillin‒streptomycin at 37 °C in a cell incubator with 5% CO2. .. Flow cytometry analysis of PD-1 levels on CD8+ T cells After being treated with IFN-α (Cat# HY-P7023, MCE, USA), Article Title: Article Snippet: BxPC-3 cells were cultured in RPMI-1640 medium supplemented with 10% (v/v) FBS and penicillin‒streptomycin at 37°C in a cell incubator with 5% CO 2 , and PANC-1 and MIA PaCa-2 cells were cultured in DMEM (Cat# C11965500BT, Thermo Fisher Scientific) supplemented with 10% (v/v) FBS and penicillin‒streptomycin at 37°C in a cell incubator with 5% CO 2 . .. After being treated with IFN-α (Cat# HY-P7023, MCE, USA), Staining:Article Title: Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma Article Snippet: BxPC-3 cells were cultured in RPMI-1640 medium supplemented with 10% (v/v) FBS and penicillin‒streptomycin at 37 °C in a cell incubator with 5% CO2, and PANC-1 and MIA PaCa-2 cells were cultured in DMEM (Cat# C11965500BT, Thermo Fisher Scientific) supplemented with 10% (v/v) FBS and penicillin‒streptomycin at 37 °C in a cell incubator with 5% CO2. .. Flow cytometry analysis of PD-1 levels on CD8+ T cells After being treated with IFN-α (Cat# HY-P7023, MCE, USA), Article Title: Article Snippet: BxPC-3 cells were cultured in RPMI-1640 medium supplemented with 10% (v/v) FBS and penicillin‒streptomycin at 37°C in a cell incubator with 5% CO 2 , and PANC-1 and MIA PaCa-2 cells were cultured in DMEM (Cat# C11965500BT, Thermo Fisher Scientific) supplemented with 10% (v/v) FBS and penicillin‒streptomycin at 37°C in a cell incubator with 5% CO 2 . .. After being treated with IFN-α (Cat# HY-P7023, MCE, USA), Saline:Article Title: Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1. Article Snippet: Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University, Nanjing, China Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy, Nanjing, China Control:Article Title: Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1. Article Snippet: Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University, Nanjing, China Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy, Nanjing, China Article Title: A multipronged Tα1 reset of CD8 + T cell cytotoxicity against breast cancer. Article Snippet: Thymosin α1 (Tα1) is an endogenous thymic peptide that enhances immune competence through activation of T cells, dendritic cells, and innate immune pathways.. However, its direct impact on CD8 T cell–mediated antitumor immunity in breast cancer remains unclear.. In this study, CD8 T cells isolated from peripheral blood of ten healthy donors were cultured under unstimulated, CD3/CD28-stimulated, Tα1-treated, or exhaustion–rescue conditions to evaluate cytotoxic activity against MDA-MB-231 breast cancer cells and CD44 cancer stem-like cells (CD44 CSC-like cells). Injection:Article Title: Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1. Article Snippet: Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University, Nanjing, China Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China Department of Clinical Pharmacy, Nanjing Medical University School of Pharmacy, Nanjing, China other:Article Title: Characterization and antitumor activities of polysaccharides derived from Inonotus sanghuang against cancers of the liver and lungs. Article Snippet: To evaluate the mechanism underlying the antitumor activity of polysaccharides derived from Inonotus sanghuang and assess the impact of fractionation on these activities, crude polysaccharides were extracted and separated into two fractions:an ethanol-precipitated crude polysaccharide (ESP) and a bioactive water-soluble polysaccharide (DSP).. Both ESP and DSP displayed distinct molecular-size distributions, and monosaccharide analysis indicated that these fractions were heteropolysaccharides composed of neutral sugars, significant amounts of uronic acids, and amino sugars.. The antitumor activities of ESP and DSP were evaluated in vitro using hepatocellular carcinoma (HepG2) and lung cancer (A549) cell lines, as well as their corresponding xenograft models. Cell Culture:Article Title: A multipronged Tα1 reset of CD8 + T cell cytotoxicity against breast cancer. Article Snippet: Thymosin α1 (Tα1) is an endogenous thymic peptide that enhances immune competence through activation of T cells, dendritic cells, and innate immune pathways.. However, its direct impact on CD8 T cell–mediated antitumor immunity in breast cancer remains unclear.. In this study, CD8 T cells isolated from peripheral blood of ten healthy donors were cultured under unstimulated, CD3/CD28-stimulated, Tα1-treated, or exhaustion–rescue conditions to evaluate cytotoxic activity against MDA-MB-231 breast cancer cells and CD44 cancer stem-like cells (CD44 CSC-like cells). |
